Developing a new treatment for superficial fungal infection using antifungal Collagen-HSAF dressing

Fungal pathogens are common causes of superficial clinical infection. Their increasing drug resistance gradually makes existing antifungal drugs ineffective. Heat stable antifungal factor (HSAF) is a novel antifungal natural product with a unique structure. However, the application of HSAF has been hampered by very low yield in the current microbial producers and from extremely poor solubility in water and common solvents. In this study, we developed an effective mode of treatment applying HSAF to superficial fungal infections. The marine-derived Lysobacter enzymogenes YC36 contains the HSAF biosynthetic gene cluster, which we activated by the interspecific signaling molecule indole. An efficient extraction strategy was used to significantly improve the purity to 95.3%. Scanning electron microscopy images revealed that the Type I collagen-based HSAF (Col-HSAF) has a transparent appearance and good physical properties, and the in vitro sustained-release effect of HSAF was maintained for more than 2 weeks. The effective therapeutic concentration of Col-HSAF against superficial fungal infection was explored, and Col-HSAF showed good biocompatibility, lower clinical scores, mild histological changes, and antifungal capabilities in animals with Aspergillus fumigatus keratitis and cutaneous candidiasis. In conclusion, Col-HSAF is an antifungal reagent with significant clinical value in the treatment of superficial fungal infections

Energy Storage Coordination in Energy Internet Based on Multi-Agent Particle Swarm Optimization

With the rapid development of energy Internet (EI), energy storage (ES), which is the key technology of EI, has attracted widespread attention. EI is composed of multiple energy networks that provide energy support for each other, so it has a great demand for diverse energy storages (ESs). All of this may result in energy redundancy throughout the whole EI system. Hence, coordinating ESs among various energy networks is of great importance. First of all, we put forward the necessity and principles of energy storage coordination (ESC) in EI. Then, the ESC model is constructed with the aim of economic efficiency (EE) and energy utilization efficiency (EUE) respectively. Finally, a multi-agent particle swarm optimization (MAPSO) algorithm is proposed to solve this problem. The calculation results are compared with that of PSO, and results show that MAPSO has good convergence and computational accuracy. In addition, the simulation results prove that EE plays the most important role when coordinating various ESs in EI, and an ES configuration with the multi-objective optimization of EE and EUE is concluded at last

Analysis of Ku- and Ka-Band Sea Surface Backscattering Characteristics at Low-Incidence Angles Based on the GPM Dual-Frequency Precipitation Radar Measurements

The co-located normalized radar backscatter cross section measurements from the Global Precipitation Measurement (GPM) Ku/Ka-band dual-frequency precipitation radar (DPR) and sea surface wind; wave and temperature observations from the National Data Buoy Center (NDBC) moored buoys are used to analyze the dependence and sensitivity of Ku- and Ka-band backscatter on surface conditions at low-incidence angles. Then the potential for inverting wind and wave parameters directly from low-incidence σ0 measurements is discussed. The results show that the KaPR σ0 is more sensitive to surface conditions than the KuPR σ0 overall. Nevertheless; both the KuPR σ0 and KaPR σ0 are strongly correlated with wind speed (U10) and average wave steepness (δa) with the exception of specific transitional incidence angles. Moreover, U10 and δa could be retrieved from pointwise σ0 near nadir and near 18°. Near 18°; wind direction information is needed as the effect of wind direction on σ0 becomes increasingly significant with incidence angle. To improve the performance of U10 retrieval; especially for low U10; auxiliary δa information would be most helpful; and sea surface temperature is better taken into account. Other wave parameters; such as significant wave height; wave period and wave age; are partly correlated with σ0. It is generally more difficult to retrieve those parameters directly from pointwise σ0. For the retrieval of those wave parameters; various auxiliary information is needed. Wind direction and wave direction cannot be retrieved from pointwise σ0

Understanding Ku-Band Ocean Radar Backscatter at Low Incidence Angles under Weak to Severe Wind Conditions by Comparison of Measurements and Models

The rain-free normalized radar cross-section (NRCS) measurements from the Ku-band precipitation radars (PRs) aboard the tropical rainfall measuring mission (TRMM) and the global precipitation measurement (GPM) mission, along with simultaneous sea surface wind truth from buoy observations, stepped-frequency microwave radiometer (SFMR) measurements, and H*Wind analyses, are used to investigate the abilities of the quasi-specular scattering models, i.e., the physical optics model (PO) and the classical and improved geometrical optics models (GO and GO4), to reproduce the Ku-band NRCS at low incidence angles of 0–18° over the wind speed range of 0–45 m/s. On this basis, the limitations of the quasi-specular scattering theory and the effects of wave breaking are discussed. The results show that the return caused by quasi-specular reflection is affected significantly by the presence of background swell waves at low winds. At moderate wind speeds of 5–15 m/s, the NRCS is still dominated by the quasi-specular reflection, and the wave breaking starts to work but its contribution is very small, thus, the models are found in excellent agreement with the measurements. With wind speed increasing, the impact of wave breaking increases, whereas the role of standard quasi-specular reflection decreases. The wave breaking impact on NRCS is first visible at incidence angles near 18° as wind speed exceeds about 20 m/s, then it becomes dominant when wind speed exceeds about 37 m/s where the NRCS is insensitive to wind speed and depends linearly on incidence angle, which cannot be explained by the standard quasi-specular scattering theory

Automatic Generation from List comprehension to C

AbstractList Comprehension representing comes from comprehension of mathematics, which provides a strong and concise representing method. Monad representing is concise and readability mainly because Monad extends List Comprehension to any Monad. This paper is concerned with the transforming from List Comprehension of functional programming language Haskell to C programs. Using Haskell itself we have also realized this transformation. Haskell is the only language that supports Monad, so our research is helpful to the building of Monad researching environments

Effects of Directional Wave Spectra on the Modeling of Ocean Radar Backscatter at Various Azimuth Angles by a Modified Two-Scale Method

Knowledge of the ocean backscatter at various azimuth angles is critical to the radar detection of the ocean environment. In this study, the modified two-scale model (TSM), which introduces a correction term in the conventional TSM, is improved based on the empirical model, CMOD5.n. Then, the influences of different directional wave spectra on the prediction of azimuthal behavior of ocean radar backscatter are investigated by comparing the simulated results with CMOD5.n and the Advanced Scatterometer (ASCAT) measurements. The results show that the overall performance of the single spectra of D, A, E, and H18 and the composite spectra of AH18 and AEH18 in predicting ocean backscatter are different at different wind speeds and incidence angles. Generally, the AH18 spectrum has better performance at low and moderate wind speeds, while the A spectrum works better at high wind speed. Nevertheless, the wave spectra have little effect on the prediction of the azimuthal fluctuation of scattering, which is highly dependent on the directional spreading function. The relative patterns of azimuthal undulation produced by different spreading functions are rather different at different wind speeds, but similar under different incidence angles. The Gaussian spreading function generally has better performance in predicting the azimuthal fluctuation of scattering

Evaluation of Multi-Incidence Angle Polarimetric Gaofen-3 SAR Wave Mode Data for Significant Wave Height Retrieval

Significant wave height (SWH) is one of the most important descriptors for ocean wave fields. The polynomial regression (PolR) and Gaussian process regression (GPR) models are implemented to explore the effects of polarization and incidence angles on the SWH estimation from multi-incidence angle quad-polarization Gaofen-3 SAR wave mode data, based on the collocated data set of approximately 12,000 Gaofen-3 wave mode imagettes, matched with SWH from the fifth generation reanalysis (ERA5) of the European Centre for Medium-Range Weather Forecasts (ECMWF). The results show that the model performance improves, as long as polarimetry information increases. The hybrid polarizations perform stronger than the co-polarizations or cross-polarizations alone, and they show better performance over the low to high seas. The lower incidence angles are more favorable for SAR SWH inversion. It is superior to introduce incidence angle in piecewise way, rather than to include it as an independent variable in the models. Then, the final PolR and GPR models, with the superior input scheme that includes the quad-polarized features and introduces the incidence angle in piecewise way, are assessed independently through a comparison with observations from altimeter and buoys. The accuracies of our SWH estimates are comparable or even higher than other published results. The GPR model outperforms the PolR model, due to the superiority of the added nonlinearity of GPR

Significant Wave Height Retrieval Using XGBoost from Polarimetric Gaofen-3 SAR and Feature Importance Analysis

Empirical algorithms have become the mainstream of significant wave height (SWH) retrieval from synthetic aperture radar (SAR). But the plentiful features from multi-polarizations make the selection of input for the empirical model a problem. Therefore, the XGBoost models are developed and evaluated for SWH retrieval from polarimetric Gaofen-3 wave mode imagettes using the SAR features of different polarization combinations, and then the importance of each feature on the models is further discussed. The results show that the reliability of SWH retrieval models is independently confirmed based on the collocations of the SAR-buoy and SAR-altimeter. Moreover, the combined-polarization models achieve better performance than single-polarizations. In addition, the importance of different features to the different polarization models for SWH inversion is not the same. For example, the normalized radar cross section (NRCS), cutoff wavelength (λc), and incident angle (θ) have more decisive contributions to the models than other features, while peak wavelength (λp) and the peak direction (φ) have almost no contribution. Besides, NRCS of cross-polarization has a more substantial effect, and the λc of hybrid polarization has a stronger one than other polarization models

Exploring the Path of China's Energy Transformation under the "Carbon Peaking & Carbon Neutrality" Goals

The key to achieving peak carbon emissions and carbon neutrality lies in the low-carbon transformation of energy and power, which is crucial to China's overall economic and social development. With the intensification of global climate change, countries are actively exploring strategies to adapt to climate change. However, coal, as the main future energy source, is expected to remain dominant, making it urgent to advance the transformation of fossil energy towards low-carbonization. In this context, this paper comprehensively analyzes the timing of the reduction of fossil energy and the replacement of non-fossil energy in China through a comparative analysis of the international and domestic energy transformation status, taking into account the need to ensure energy supply security and achieve China's economic and social development goals. The paper proposes development suggestions for China's energy development path, including optimizing and upgrading the industrial structure, building a clean and low-carbon energy system, strengthening CCUS technology development, and leveraging market mechanisms. These recommendations provide a certain reference and guidance for China to achieve its energy transformation goals

Transcriptome Analysis of the Preservation Effect of Three Essential Oil Microcapsules on Okra

Cinnamon (Cinnamomum sp.) essential oil microcapsules, oregano (Origanum sp.) essential oil microcapsules, and oregano–thyme (Thymus sp.) essential oil microcapsules are rarely used in the postharvest preservation treatment of okra (Abelmoschus esculentus L.). The mechanism of these three essential oil microcapsules on the postharvest preservation of okra is also not yet well understood. In this study, fresh okra was preserved by three kinds of essential oil microcapsules (cinnamon essential oil microcapsules, oregano essential oil microcapsules, and oregano–thyme essential oil microcapsules). The effect of essential oil microcapsules on the postharvest storage quality of okra was discussed. We also used RNA-Seq to preliminarily explore the mechanism of oregano–thyme essential oil microcapsules on the pre-harvest storage quality of okra. The results showed that the three kinds of essential oil microcapsules could maintain the high sensory evaluation quality and firmness of okra, slow down the increase in respiratory intensity, slow down the total number of colonies on the fruit surface, and slow down weight loss. Through analysis, it was found that the effect of oregano–thyme essential oil microcapsules was remarkably better than that of cinnamon essential oil microcapsules and oregano essential oil microcapsules. The preservation mechanism of oregano–thyme essential oil microcapsules on postharvest okra was preliminarily elucidated by RNA-Seq. This study provides a certain basis for a follow-up study of essential oil microcapsules in the preservation of okra