1 research outputs found
Tumor-Homing and Immune-Reprogramming Cellular Nanovesicles for Photoacoustic Imaging-Guided Phototriggered Precise Chemoimmunotherapy
Many studies have focused on developing effective therapeutic
strategies
to selectively destroy primary tumors, eliminate metastatic lesions,
and prevent tumor recurrence with minimal side effects on normal tissues.
In this work, we synthesized engineered cellular nanovesicles (ECNVs)
with tumor-homing and immune-reprogramming functions for photoacoustic
(PA) imaging-guided precision chemoimmunotherapy. M1-macrophage-derived
cellular nanovesicles (CNVs) were loaded with gold nanorods (GNRs),
gemcitabine (GEM), CpG ODN, and PD-L1 aptamer. The good histocompatibility
and tumor-homing effect of CNVs improved drug retention in the bloodstream
and led to their enrichment in tumor tissues. Furthermore, the photothermal
ability of GNRs enabled PA imaging-guided drug release. GEM induced
tumor immunogenic cell death (ICD), and CpG ODN promoted an immune
response to the antigens released by ICD, leading to long-term specific
antitumor immunity. In addition, the PD-L1 aptamer relieved the inhibitory
effect of the PD1/PD-L1 checkpoint on CD8+ T-cells and
augmented the immunotherapeutic effect. The synergistic innate and
adaptive immune responses enhanced the antitumor effect of ECNVs.
In summary, this nanoplatform integrates local targeted photothermal
therapy with extensive progressive chemotherapy and uses ICD to reshape
the immune microenvironment for tumor ablation