10 research outputs found
A Bioenvironment-Responsive Versatile Nanoplatform Enabling Rapid Clearance and Effective Tumor Homing for Oxygen-Enhanced Radiotherapy
Nanoradiosensitizer-augmented
cancer radiotherapy (RT) has been
widely investigated, whereas the desirable nanoradiosensitizer with
the characteristics of rapid clearance, effective tumor homing, and
tumor hypoxia relief is still lacking. Herein, bismuth sulfide–albumin
composite nanospheres followed by catalase conjugation (denoted as
BSNSs-CAT) have been well constructed as a bioenvironment-responsive
nanoradiosensitizer platform. The BSNSs-CAT phagocytosed by normal
cells demonstrate architectural disintegration into small ones in
response to physiological pH, achieving small size-favored rapid clearance,
which largely mitigates the concern of long-term toxicity of BSNSs-CAT
in normal tissues. More importantly, benefiting from their large size-favored
enhanced permeability and retention effect, BSNSs-CAT accumulate efficiently
in tumors and remain architecturally stable in a mildly acidic tumor
microenvironment (TME), which strongly favors a response with H<sub>2</sub>O<sub>2</sub> overproduced TME. As a result, the produced
intratumor oxygen could overcome tumor hypoxia-associated RT resistance,
together with the radiosensitization effect of bismuth, collectively
enhancing RT efficacy. This research demonstrates a versatile material
solution by fully exploring its bioenvironment-responsive nature,
offering a new strategy for nanomedicine design and application
Nonhalogenated Solvent Processable and Printable High-Performance Polymer Semiconductor Enabled by Isomeric Nonconjugated Flexible Linkers
One
major advantage of organic electronics is their superior processability
relative to traditional silicon-based materials. However, most high-performing
polymer semiconductors exhibit poor solubility and require toxic chlorinated
solvents coupled with inefficient coating methods such as spin-coating
for device fabrication. Therefore, developing polymer semiconductors
that are processable in environmentally benign solvents and compatible
with effective printing techniques while maintaining good charge transport
properties is crucial for the industrialization of low-cost and lightweight
plastic electronics. In this study, alkyl flexible linkers with branched
tertiary carbon atoms are inserted to a high-mobility diketopyrrolopyrrole-based
polymer backbone to suppress polymer aggregation in solution, decrease
crystallinity, and increase free volume. The polymer readily dissolves
in industrial solvents and shows a 70-fold increase in solubility
compared to its fully conjugated counterpart. Furthermore, due to
its high solubility, the polymer can be inkjet-printed and solution-sheared
at high concentrations using eco-friendly solvents such as <i>p</i>-xylene and 2-methyltetraÂhydrofuran with a maximum
hole mobility of 2.76 cm<sup>2</sup> V<sup>–1</sup> s<sup>–1</sup> and on–off ratio above 10<sup>5</sup> in organic field-effect
transistors
Quadruple H‑Bonding Cross-Linked Supramolecular Polymeric Materials as Substrates for Stretchable, Antitearing, and Self-Healable Thin Film Electrodes
Herein,
we report a de novo chemical design of supramolecular polymer materials
(SPMs-<b>1</b>–<b>3</b>) by condensation polymerization,
consisting of (i) soft polymeric chains (polytetramethylene glycol
and tetraethylene glycol) and (ii) strong and reversible quadruple
H-bonding cross-linkers (from 0 to 30 mol %). The former contributes
to the formation of the soft domain of the SPMs, and the latter furnishes
the SPMs with desirable mechanical properties, thereby producing soft,
stretchable, yet tough elastomers. The resulting SPM-<b>2</b> was observed to be highly stretchable (up to 17 000% strain),
tough (fracture energy ∼30 000 J/m<sup>2</sup>), and
self-healing, which are highly desirable properties and are superior
to previously reported elastomers and tough hydrogels. Furthermore,
a gold, thin film electrode deposited on this SPM substrate retains
its conductivity and combines high stretchability (∼400%),
fracture/notch insensitivity, self-healing, and good interfacial adhesion
with the gold film. Again, these properties are all highly complementary
to commonly used polydimethylsiloxane-based thin film metal electrodes.
Last, we proceed to demonstrate the practical utility of our fabricated
electrode via both in vivo and in vitro measurements of electromyography
signals. This fundamental understanding obtained from the investigation
of these SPMs will facilitate the progress of intelligent soft materials
and flexible electronics
Quadruple H‑Bonding Cross-Linked Supramolecular Polymeric Materials as Substrates for Stretchable, Antitearing, and Self-Healable Thin Film Electrodes
Herein,
we report a de novo chemical design of supramolecular polymer materials
(SPMs-<b>1</b>–<b>3</b>) by condensation polymerization,
consisting of (i) soft polymeric chains (polytetramethylene glycol
and tetraethylene glycol) and (ii) strong and reversible quadruple
H-bonding cross-linkers (from 0 to 30 mol %). The former contributes
to the formation of the soft domain of the SPMs, and the latter furnishes
the SPMs with desirable mechanical properties, thereby producing soft,
stretchable, yet tough elastomers. The resulting SPM-<b>2</b> was observed to be highly stretchable (up to 17 000% strain),
tough (fracture energy ∼30 000 J/m<sup>2</sup>), and
self-healing, which are highly desirable properties and are superior
to previously reported elastomers and tough hydrogels. Furthermore,
a gold, thin film electrode deposited on this SPM substrate retains
its conductivity and combines high stretchability (∼400%),
fracture/notch insensitivity, self-healing, and good interfacial adhesion
with the gold film. Again, these properties are all highly complementary
to commonly used polydimethylsiloxane-based thin film metal electrodes.
Last, we proceed to demonstrate the practical utility of our fabricated
electrode via both in vivo and in vitro measurements of electromyography
signals. This fundamental understanding obtained from the investigation
of these SPMs will facilitate the progress of intelligent soft materials
and flexible electronics
Quadruple H‑Bonding Cross-Linked Supramolecular Polymeric Materials as Substrates for Stretchable, Antitearing, and Self-Healable Thin Film Electrodes
Herein,
we report a de novo chemical design of supramolecular polymer materials
(SPMs-<b>1</b>–<b>3</b>) by condensation polymerization,
consisting of (i) soft polymeric chains (polytetramethylene glycol
and tetraethylene glycol) and (ii) strong and reversible quadruple
H-bonding cross-linkers (from 0 to 30 mol %). The former contributes
to the formation of the soft domain of the SPMs, and the latter furnishes
the SPMs with desirable mechanical properties, thereby producing soft,
stretchable, yet tough elastomers. The resulting SPM-<b>2</b> was observed to be highly stretchable (up to 17 000% strain),
tough (fracture energy ∼30 000 J/m<sup>2</sup>), and
self-healing, which are highly desirable properties and are superior
to previously reported elastomers and tough hydrogels. Furthermore,
a gold, thin film electrode deposited on this SPM substrate retains
its conductivity and combines high stretchability (∼400%),
fracture/notch insensitivity, self-healing, and good interfacial adhesion
with the gold film. Again, these properties are all highly complementary
to commonly used polydimethylsiloxane-based thin film metal electrodes.
Last, we proceed to demonstrate the practical utility of our fabricated
electrode via both in vivo and in vitro measurements of electromyography
signals. This fundamental understanding obtained from the investigation
of these SPMs will facilitate the progress of intelligent soft materials
and flexible electronics
Quadruple H‑Bonding Cross-Linked Supramolecular Polymeric Materials as Substrates for Stretchable, Antitearing, and Self-Healable Thin Film Electrodes
Herein,
we report a de novo chemical design of supramolecular polymer materials
(SPMs-<b>1</b>–<b>3</b>) by condensation polymerization,
consisting of (i) soft polymeric chains (polytetramethylene glycol
and tetraethylene glycol) and (ii) strong and reversible quadruple
H-bonding cross-linkers (from 0 to 30 mol %). The former contributes
to the formation of the soft domain of the SPMs, and the latter furnishes
the SPMs with desirable mechanical properties, thereby producing soft,
stretchable, yet tough elastomers. The resulting SPM-<b>2</b> was observed to be highly stretchable (up to 17 000% strain),
tough (fracture energy ∼30 000 J/m<sup>2</sup>), and
self-healing, which are highly desirable properties and are superior
to previously reported elastomers and tough hydrogels. Furthermore,
a gold, thin film electrode deposited on this SPM substrate retains
its conductivity and combines high stretchability (∼400%),
fracture/notch insensitivity, self-healing, and good interfacial adhesion
with the gold film. Again, these properties are all highly complementary
to commonly used polydimethylsiloxane-based thin film metal electrodes.
Last, we proceed to demonstrate the practical utility of our fabricated
electrode via both in vivo and in vitro measurements of electromyography
signals. This fundamental understanding obtained from the investigation
of these SPMs will facilitate the progress of intelligent soft materials
and flexible electronics
Quadruple H‑Bonding Cross-Linked Supramolecular Polymeric Materials as Substrates for Stretchable, Antitearing, and Self-Healable Thin Film Electrodes
Herein,
we report a de novo chemical design of supramolecular polymer materials
(SPMs-<b>1</b>–<b>3</b>) by condensation polymerization,
consisting of (i) soft polymeric chains (polytetramethylene glycol
and tetraethylene glycol) and (ii) strong and reversible quadruple
H-bonding cross-linkers (from 0 to 30 mol %). The former contributes
to the formation of the soft domain of the SPMs, and the latter furnishes
the SPMs with desirable mechanical properties, thereby producing soft,
stretchable, yet tough elastomers. The resulting SPM-<b>2</b> was observed to be highly stretchable (up to 17 000% strain),
tough (fracture energy ∼30 000 J/m<sup>2</sup>), and
self-healing, which are highly desirable properties and are superior
to previously reported elastomers and tough hydrogels. Furthermore,
a gold, thin film electrode deposited on this SPM substrate retains
its conductivity and combines high stretchability (∼400%),
fracture/notch insensitivity, self-healing, and good interfacial adhesion
with the gold film. Again, these properties are all highly complementary
to commonly used polydimethylsiloxane-based thin film metal electrodes.
Last, we proceed to demonstrate the practical utility of our fabricated
electrode via both in vivo and in vitro measurements of electromyography
signals. This fundamental understanding obtained from the investigation
of these SPMs will facilitate the progress of intelligent soft materials
and flexible electronics
Quadruple H‑Bonding Cross-Linked Supramolecular Polymeric Materials as Substrates for Stretchable, Antitearing, and Self-Healable Thin Film Electrodes
Herein,
we report a de novo chemical design of supramolecular polymer materials
(SPMs-<b>1</b>–<b>3</b>) by condensation polymerization,
consisting of (i) soft polymeric chains (polytetramethylene glycol
and tetraethylene glycol) and (ii) strong and reversible quadruple
H-bonding cross-linkers (from 0 to 30 mol %). The former contributes
to the formation of the soft domain of the SPMs, and the latter furnishes
the SPMs with desirable mechanical properties, thereby producing soft,
stretchable, yet tough elastomers. The resulting SPM-<b>2</b> was observed to be highly stretchable (up to 17 000% strain),
tough (fracture energy ∼30 000 J/m<sup>2</sup>), and
self-healing, which are highly desirable properties and are superior
to previously reported elastomers and tough hydrogels. Furthermore,
a gold, thin film electrode deposited on this SPM substrate retains
its conductivity and combines high stretchability (∼400%),
fracture/notch insensitivity, self-healing, and good interfacial adhesion
with the gold film. Again, these properties are all highly complementary
to commonly used polydimethylsiloxane-based thin film metal electrodes.
Last, we proceed to demonstrate the practical utility of our fabricated
electrode via both in vivo and in vitro measurements of electromyography
signals. This fundamental understanding obtained from the investigation
of these SPMs will facilitate the progress of intelligent soft materials
and flexible electronics
Quadruple H‑Bonding Cross-Linked Supramolecular Polymeric Materials as Substrates for Stretchable, Antitearing, and Self-Healable Thin Film Electrodes
Herein,
we report a de novo chemical design of supramolecular polymer materials
(SPMs-<b>1</b>–<b>3</b>) by condensation polymerization,
consisting of (i) soft polymeric chains (polytetramethylene glycol
and tetraethylene glycol) and (ii) strong and reversible quadruple
H-bonding cross-linkers (from 0 to 30 mol %). The former contributes
to the formation of the soft domain of the SPMs, and the latter furnishes
the SPMs with desirable mechanical properties, thereby producing soft,
stretchable, yet tough elastomers. The resulting SPM-<b>2</b> was observed to be highly stretchable (up to 17 000% strain),
tough (fracture energy ∼30 000 J/m<sup>2</sup>), and
self-healing, which are highly desirable properties and are superior
to previously reported elastomers and tough hydrogels. Furthermore,
a gold, thin film electrode deposited on this SPM substrate retains
its conductivity and combines high stretchability (∼400%),
fracture/notch insensitivity, self-healing, and good interfacial adhesion
with the gold film. Again, these properties are all highly complementary
to commonly used polydimethylsiloxane-based thin film metal electrodes.
Last, we proceed to demonstrate the practical utility of our fabricated
electrode via both in vivo and in vitro measurements of electromyography
signals. This fundamental understanding obtained from the investigation
of these SPMs will facilitate the progress of intelligent soft materials
and flexible electronics
Quadruple H‑Bonding Cross-Linked Supramolecular Polymeric Materials as Substrates for Stretchable, Antitearing, and Self-Healable Thin Film Electrodes
Herein,
we report a de novo chemical design of supramolecular polymer materials
(SPMs-<b>1</b>–<b>3</b>) by condensation polymerization,
consisting of (i) soft polymeric chains (polytetramethylene glycol
and tetraethylene glycol) and (ii) strong and reversible quadruple
H-bonding cross-linkers (from 0 to 30 mol %). The former contributes
to the formation of the soft domain of the SPMs, and the latter furnishes
the SPMs with desirable mechanical properties, thereby producing soft,
stretchable, yet tough elastomers. The resulting SPM-<b>2</b> was observed to be highly stretchable (up to 17 000% strain),
tough (fracture energy ∼30 000 J/m<sup>2</sup>), and
self-healing, which are highly desirable properties and are superior
to previously reported elastomers and tough hydrogels. Furthermore,
a gold, thin film electrode deposited on this SPM substrate retains
its conductivity and combines high stretchability (∼400%),
fracture/notch insensitivity, self-healing, and good interfacial adhesion
with the gold film. Again, these properties are all highly complementary
to commonly used polydimethylsiloxane-based thin film metal electrodes.
Last, we proceed to demonstrate the practical utility of our fabricated
electrode via both in vivo and in vitro measurements of electromyography
signals. This fundamental understanding obtained from the investigation
of these SPMs will facilitate the progress of intelligent soft materials
and flexible electronics