Conceptual Study and Performance Analysis of Tandem Dual-Antenna Spaceborne SAR Interferometry

Multi-baseline synthetic aperture radar interferometry (MB-InSAR), capable of mapping 3D surface model with high precision, is able to overcome the ill-posed problem in the single-baseline InSAR by use of the baseline diversity. Single pass MB acquisition with the advantages of high coherence and simple phase components has a more practical capability in 3D reconstruction than conventional repeat-pass MB acquisition. Using an asymptotic 3D phase unwrapping (PU), it is possible to get a reliable 3D reconstruction using very sparse acquisitions but the interferograms should follow the optimal baseline design. However, current spaceborne SAR system doesn't satisfy this principle, inducing more difficulties in practical application. In this article, a new concept of Tandem Dual-Antenna SAR Interferometry (TDA-InSAR) system for single-pass reliable 3D surface mapping using the asymptotic 3D PU is proposed. Its optimal MB acquisition is analyzed to achieve both good relative height precision and flexible baseline design. Two indicators, i.e., expected relative height precision and successful phase unwrapping rate, are selected to optimize the system parameters and evaluate the performance of various baseline configurations. Additionally, simulation-based demonstrations are conducted to evaluate the performance in typical scenarios and investigate the impact of various error sources. The results indicate that the proposed TDA-InSAR is able to get the specified MB acquisition for the asymptotic 3D PU, which offers a feasible solution for single-pass 3D SAR imaging.Comment: 16 pages, 20 figure

ATASI-Net: An Efficient Sparse Reconstruction Network for Tomographic SAR Imaging with Adaptive Threshold

Tomographic SAR technique has attracted remarkable interest for its ability of three-dimensional resolving along the elevation direction via a stack of SAR images collected from different cross-track angles. The emerged compressed sensing (CS)-based algorithms have been introduced into TomoSAR considering its super-resolution ability with limited samples. However, the conventional CS-based methods suffer from several drawbacks, including weak noise resistance, high computational complexity, and complex parameter fine-tuning. Aiming at efficient TomoSAR imaging, this paper proposes a novel efficient sparse unfolding network based on the analytic learned iterative shrinkage thresholding algorithm (ALISTA) architecture with adaptive threshold, named Adaptive Threshold ALISTA-based Sparse Imaging Network (ATASI-Net). The weight matrix in each layer of ATASI-Net is pre-computed as the solution of an off-line optimization problem, leaving only two scalar parameters to be learned from data, which significantly simplifies the training stage. In addition, adaptive threshold is introduced for each azimuth-range pixel, enabling the threshold shrinkage to be not only layer-varied but also element-wise. Moreover, the final learned thresholds can be visualized and combined with the SAR image semantics for mutual feedback. Finally, extensive experiments on simulated and real data are carried out to demonstrate the effectiveness and efficiency of the proposed method

Skeleton Supervised Airway Segmentation

Fully-supervised airway segmentation has accomplished significant triumphs over the years in aiding pre-operative diagnosis and intra-operative navigation. However, full voxel-level annotation constitutes a labor-intensive and time-consuming task, often plagued by issues such as missing branches, branch annotation discontinuity, or erroneous edge delineation. label-efficient solutions for airway extraction are rarely explored yet primarily demanding in medical practice. To this end, we introduce a novel skeleton-level annotation (SkA) tailored to the airway, which simplifies the annotation workflow while enhancing annotation consistency and accuracy, preserving the complete topology. Furthermore, we propose a skeleton-supervised learning framework to achieve accurate airway segmentation. Firstly, a dual-stream buffer inference is introduced to realize initial label propagation from SkA, avoiding the collapse of direct learning from SkA. Then, we construct a geometry-aware dual-path propagation framework (GDP) to further promote complementary propagation learning, composed of hard geometry-aware propagation learning and soft geometry-aware propagation guidance. Experiments reveal that our proposed framework outperforms the competing methods with SKA, which amounts to only 1.96% airways, and achieves comparable performance with the baseline model that is fully supervised with 100% airways, demonstrating its significant potential in achieving label-efficient segmentation for other tubular structures, such as vessels

SPHR-SAR-Net: Superpixel High-resolution SAR Imaging Network Based on Nonlocal Total Variation

High-resolution is a key trend in the development of synthetic aperture radar (SAR), which enables the capture of fine details and accurate representation of backscattering properties. However, traditional high-resolution SAR imaging algorithms face several challenges. Firstly, these algorithms tend to focus on local information, neglecting non-local information between different pixel patches. Secondly, speckle is more pronounced and difficult to filter out in high-resolution SAR images. Thirdly, the process of high-resolution SAR imaging generally involves high time and computational complexity, making real-time imaging difficult to achieve. To address these issues, we propose a Superpixel High-Resolution SAR Imaging Network (SPHR-SAR-Net) for rapid despeckling in high-resolution SAR mode. Based on the concept of superpixel techniques, we initially combine non-convex and non-local total variation as compound regularization. This approach more effectively despeckles and manages the relationship between pixels while reducing bias effects caused by convex constraints. Subsequently, we solve the compound regularization model using the Alternating Direction Method of Multipliers (ADMM) algorithm and unfold it into a Deep Unfolded Network (DUN). The network's parameters are adaptively learned in a data-driven manner, and the learned network significantly increases imaging speed. Additionally, the Deep Unfolded Network is compatible with high-resolution imaging modes such as spotlight, staring spotlight, and sliding spotlight. In this paper, we demonstrate the superiority of SPHR-SAR-Net through experiments in both simulated and real SAR scenarios. The results indicate that SPHR-SAR-Net can rapidly perform high-resolution SAR imaging from raw echo data, producing accurate imaging results

Non-line-of-sight Target Relocation by Multipath Model in SAR 3D Urban Area Imaging

The advancement in the miniaturization technology of Synthetic Aperture Radar (SAR) systems and SAR three-dimensional (3D) imaging has enabled the 3D imaging of urban areas through Unmanned Aerial Vehicle (UAV)-borne array Interferometric SAR (array-InSAR), offering significant utility in urban cartography, complex environment reconstruction, and related domains. Despite the challenges posed by multipath signals in urban scene imaging, these signals serve as a crucial asset for imaging hidden targets in Non-Line-of-Sight (NLOS) areas. Hence, this paper studies NLOS targets in UAV-borne array-InSAR 3D imaging at low altitudes and establishes a multipath model for 3D imaging at low altitudes. Then, a calculation method is proposed for obtaining the multipath reachable range in urban canyon areas based on building plane fitting. Finally, a relocation method for NLOS targets is presented. The simulation and real data experiments of UAV-borne array-InSAR show that the proposed method can effectively obtain 3D images and relocate NLOS targets in urban canyon areas, with errors typically below 0.5 m, which realizes the acquisition of hidden NLOS region information

Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis

The sense of smell allows chemicals to be perceived as diverse scents. We used single neuron RNA-Sequencing (RNA-Seq) to explore developmental mechanisms that shape this ability as nasal olfactory neurons mature in mice. Most mature neurons expressed only one of the roughly 1000 odorant receptor genes (Olfrs) available, and that at high levels. However, many immature neurons expressed low levels of multiple Olfrs. Coexpressed Olfrs localized to overlapping zones of the nasal epithelium, suggesting regional biases, but not to single genomic loci. A single immature neuron could express Olfrs from up to seven different chromosomes. The mature state in which expression of Olfr genes is restricted to one per neuron emerges over a developmental progression that appears independent of neuronal activity requiring sensory transduction molecules

A new simplified and robust Surface Reflectance Estimation Method (SREM) for use over diverse land surfaces using multi-sensor data

Surface reflectance (SR) estimation is the most critical pre-processing step for deriving geophysical parameters in multi-sensor remote sensing. Most state-of-the-art SR estimation methods, such as the vector version of the Second Simulation of the Satellite Signal in the Solar Spectrum (6SV) Radiative Transfer (RT) model, depend on accurate information on aerosol and atmospheric gases. In this study, a Simplified and Robust Surface Reflectance Estimation Method (SREM) based on the equations from 6SV RT model, without integrating information of aerosol particles and atmospheric gasses, is proposed and tested using Landsat 5 Thematic Mapper (TM), Landsat 7 Enhanced Thematic Mapper plus (ETM+), and Landsat 8 Operational Land Imager (OLI) data from 2000 to 2018. For evaluation purposes, (i) the SREM SR retrievals are validated against in-situ SR measurements collected by Analytical Spectral Devices (ASD) for the South Dakota State University (SDSU) site, USA (ii) cross-comparison between the SREM and Landsat spectral SR products, i.e., Landsat Ecosystem Disturbance Adaptive Processing System (LEDAPS) and Landsat 8 Surface Reflectance Code (LaSRC), are conducted over 11 urban (2013-2018), 13 vegetated (2013-2018), and 11 desert/arid (2000 to 2018) sites located over different climatic zones at global scale, (iii) the performance of the SREM spectral SR retrievals for low to high aerosol loadings is evaluated, (iv) spatio-temporal cross-comparison is conducted for six Landsat paths/rows located in Asia, Africa, Europe, and the USA from 2013 to 2018 to consider a large variety of land surfaces and atmospheric conditions, (v) cross-comparison is also performed for the Normalized Difference Vegetation Index (NDVI), the Enhanced Vegetation Index (EVI), and the Soil Adjusted Vegetation Index (SAVI) calculated from both the SREM and Landsat SR data, (vi) the SREM is also applied to the Sentinel-2A and Moderate Resolution Imaging Spectrometer (MODIS) data to explore its applicability, and (vii) errors in the SR retrievals are reported using the Mean Bias Error (MBE), Root Mean Squared Deviation (RMSD) and Mean Systematic Error (MSE). Results depict significant and strong positive Pearson’s correlation (r), small MBE, RMSD, and MSE for each spectral band against in-situ ASD data and Landsat (LEDAPS and LaSRC) SR products. Consistency in SREM performance against Sentinel-2A (r = 0.994, MBE = - 0.009, and RMSD = 0.014) and MODIS (r = 0.925, MBE = 0.007, and RMSD = 0.014) data suggests that SREM can be applied to other multispectral satellites data. Overall, the findings demonstrate the potential and promise of SREM for use over diverse surfaces and under varying atmospheric conditions using multi-sensor data on a global scale

The role of tumor-associated macrophages in glioma cohort: through both traditional RNA sequencing and single cell RNA sequencing

Gliomas are the leading cause in more than 50% of malignant brain tumor cases. Prognoses, recurrences, and mortality are usually poor for gliomas that have malignant features. In gliomas, there are four grades, with grade IV gliomas known as glioblastomas (GBM). Currently, the primary methods employed for glioma treatment include surgical removal, followed by chemotherapy after the operation, and targeted therapy. However, the outcomes of these treatments are unsatisfactory. Gliomas have a high number of tumor-associated macrophages (TAM), which consist of brain microglia and macrophages, making them the predominant cell group in the tumor microenvironment (TME). The glioma cohort was analyzed using single-cell RNA sequencing to quantify the genes related to TAMs in this study. Furthermore, the ssGSEA analysis was utilized to assess the TAM-associated score in the glioma group. In the glioma cohort, we have successfully developed a prognostic model consisting of 12 genes, which is derived from the TAM-associated genes. The glioma cohort demonstrated the predictive significance of the TAM-based risk model through survival analysis and time-dependent ROC curve. Furthermore, the correlation analysis revealed the significance of the TAM-based risk model in the application of immunotherapy for individuals diagnosed with GBM. Ultimately, the additional examination unveiled the prognostic significance of PTX3 in the glioma group, establishing it as the utmost valuable prognostic indicator in patients with GBM. The PCR assay revealed the PTX3 is significantly up-regulated in GBM cohort. Additionally, the assessment of cell growth further confirms the involvement of PTX3 in the GBM group. The analysis of cell proliferation showed that the increased expression of PTX3 enhanced the ability of glioma cells to proliferate. The prognosis of glioblastomas and glioma is influenced by the proliferation of tumor-associated macrophages

MPOLSAR-1.0: Multidimensional SAR Multiband Fully Polarized Fine Classification Dataset

Fine terrain classification is one of the main applications of Synthetic Aperture Radar (SAR). In the multiband fully polarized SAR operating mode, obtaining information on different frequency bands of the target and polarization response characteristics of a target is possible, which can improve target classification accuracy. However, the existing datasets at home and abroad only have low-resolution fully polarized classification data for individual bands, limited regions, and small samples. Thus, a multidimensional SAR dataset from Hainan is used to construct a multiband fully polarized fine classification dataset with ample sample size, diverse land cover categories, and high classification reliability. This dataset will promote the development of multiband fully polarized SAR classification applications, supported by the high-resolution aerial observation system application calibration and verification project. This paper provides an overview of the composition of the dataset, and describes the information and dataset production methods for the first batch of published data (MPOLSAR-1.0). Furthermore, this study presents the preliminary classification experimental results based on the polarization feature classification and classical machine learning classification methods, providing support for the sharing and application of the dataset