Additional file 1: of Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

Buformin does not upregulate AMPK activation in MMTV-erbB-2 mice. Representative images of p-AMPK immunostained mammary tissues from 18-week-old MMTV-erbB-2 mice that were fed control or buformin diets for 10 weeks are shown. (TIF 789 kb

Cox proportional hazards model for the development of eGFR <60 ml/min/1.73m² after ART initiation among patients with baseline eGFR >90 ml/min/1.73m².

<p>eGFR: estimated glomerular filtration rate, HR: hazard ratios, CI: confidence interval, TMP-SMZ: trimethoprim/sulfamethoxazole, ART: antiretroviral therapy, TDF: tenofovir disoproxil fumarate, NNRTI: non-nucleoside reverse transciptase, LPV/r: lopinavir/ritonavir.</p><p>Adjusted HRs were calculated using multivariable Cox models.</p><p>Cox proportional hazards model for the development of eGFR <60 ml/min/1.73m² after ART initiation among patients with baseline eGFR >90 ml/min/1.73m².</p

Development of the study cohort.

<p>Development of the study cohort.</p

Predictors of the baseline eGFR<60 ml/min/1.73m².

<p>eGFR: estimated glomerular filtration rate, OR: odds ratio, CI: confidence interval, IQR: interquartile range, TMP-SMZ: trimethoprim/sulfamethoxazole</p><p>Adjusted ORs were calculated through multivariable analysis using a logistic regression model.</p><p>Predictors of the baseline eGFR<60 ml/min/1.73m².</p

Characteristics and genotypes of HCV in patients with HIV/HCV co-infection^a.

<p>Characteristics and genotypes of HCV in patients with HIV/HCV co-infection<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161844#t001fn002" target="_blank">^a</a>.</p

Age distribution among different HCV subtypes^a.

<p>Age distribution among different HCV subtypes<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161844#t003fn001" target="_blank">^a</a>.</p

Genotypes distribution in patients with different risk behaviors^a.

<p>Genotypes distribution in patients with different risk behaviors<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161844#t004fn002" target="_blank">^a</a>.</p

Phylogenetic trees of HCV NS5B gene of patients with HIV/HCV co-infection.

<p>There were 5 HCV genotypes and 10 subtypes identified in our studied population, but their frequencies were not equally distributed amongst the group.</p

HCV genotype distribution in the Guangdong group and the non-Guangdong group between the 2005–2008 and 2009–2010 cohort.

<p>Genotypes 3 and 6a were more common in the non-Guangdong group from 2009–2010 compared to 2005–2008.</p