Cytotoxic pimarane-type diterpenes from the marine sediment-derived fungus <i>Eutypella</i> sp. FS46

<p>Two new pimarane-type diterpenes, scopararanes H-I (<b>1</b>–<b>2</b>), along with five known ones (<b>3</b>–<b>7</b>) were isolated from the culture broth of a marine sediment-derived fungus <i>Eutypella</i> sp. FS46, which was obtained from the South China Sea. Their structures were established by extensive spectroscopic analysis. All of them were evaluated for their cytotoxic activities against MCF-7, NCI-H460 and SF-268 tumour cell lines. Scopararane I (<b>2</b>) showed moderate inhibitory activities.</p