QCD and Relativistic O(αsv2)O(\alpha_{s}v^2) Corrections to Hadronic Decays of Spin-Singlet Heavy Quarkonia hc,hbh_c, h_b and ηb\eta_b

We calculate the annihilation decay widths of spin-singlet heavy quarkonia $h_c, h_b$ and $\eta_b$} into light hadrons with both QCD and relativistic corrections at order $O(\alpha_{s}v^{2})$ in nonrelativistic QCD. With appropriate estimates for the long-distance matrix elements by using the potential model and operator evolution method, we find that our predictions of these decay widths are consistent with recent experimental measurements. We also find that the $O(\alpha_{s}v^{2})$ corrections are small for $b\bar{b}$ states but substantial for $c\bar{c}$ states. In particular, the negative contribution of $O(\alpha_{s}v^{2})$ correction to the $h_{c}$ decay can lower the decay width, as compared with previous predictions without the $O(\alpha_{s}v^{2})$ correction, and thus result in a good agreement with the recent BESIII measurement.Comment: version published in PRD, 30 pages, 8 figures, more discussions on LDMEs adde

Free Boundary Minimal Surfaces in the Unit Three-Ball via Desingularization of the Critical Catenoid and the Equatorial Disk

We construct a new family of high genus examples of free boundary minimal surfaces in the Euclidean unit 3-ball by desingularizing the intersection of a coaxial pair of a critical catenoid and an equatorial disk. The surfaces are constructed by singular perturbation methods and have three boundary components. They are the free boundary analogue of the Costa-Hoffman-Meeks surfaces and the surfaces constructed by Kapouleas by desingularizing coaxial catenoids and planes. It is plausible that the minimal surfaces we constructed here are the same as the ones obtained recently by Ketover using the min-max method.Comment: 45 pages, 10 figure

Y Chromosomes of 40% Chinese Are Descendants of Three Neolithic Super-grandfathers

Demographic change of human populations is one of the central questions for delving into the past of human beings. To identify major population expansions related to male lineages, we sequenced 78 East Asian Y chromosomes at 3.9 Mbp of the non-recombining region (NRY), discovered >4,000 new SNPs, and identified many new clades. The relative divergence dates can be estimated much more precisely using molecular clock. We found that all the Paleolithic divergences were binary; however, three strong star-like Neolithic expansions at ~6 kya (thousand years ago) (assuming a constant substitution rate of 1e-9/bp/year) indicates that ~40% of modern Chinese are patrilineal descendants of only three super-grandfathers at that time. This observation suggests that the main patrilineal expansion in China occurred in the Neolithic Era and might be related to the development of agriculture.Comment: 29 pages of article text including 1 article figure, 9 pages of SI text, and 2 SI figures. 5 SI tables are in a separate ancillary fil

Survival after alcohol septal ablation versus conservative therapy in obstructive hypertrophic cardiomyopathy

Background: The impact of alcohol septal ablation (ASA) on the survival of patients with drug-refractory obstructive hypertrophic cardiomyopathy (HCM) remains unresolved. The aim of this study was to compare survival after ASA vs. conservative therapy. Methods: We studied a consecutive cohort of 274 patients with severe drug-refractory obstructive HCM, 229 in ASA group and 45 in conservative group. The primary endpoint was a composite of all-cause mortality and aborted cardiac arrest. Results: With a median follow-up of 4.3 years, primary endpoint occurred in 13 (5.7%) patients in the ASA group, and 8 (17.8%) patients in the conservative group. The 5- and 10-year survival free from primary endpoint of the ASA group (94.5% and 93.0%, respectively) was significantly better than that of the conservative group (78.3% and 72.2%, respectively, log-rank p = 0.009). Independent determinants of primary endpoint were ASA therapy (hazard ratio [HR] 0.22; 95% confidence interval [CI] 0.08–0.60; p = 0.003) and maximal septal thickness (HR 1.14; 95% CI 1.03–1.27; p = 0.011). Conclusions: In patients with severe drug-refractory obstructive HCM, survival after ASA is favorable and better than that of conservative therapy. ASA seems to improve survival

Quantitative Proteomic Study of Human Lung Squamous Carcinoma and Normal Bronchial Epithelial Acquired by Laser Capture Microdissection

Objective. To investigate the differential protein profile of human lung squamous carcinoma (HLSC) and normal bronchial epithelium (NBE) and provide preliminary results for further study to explore the carcinogenic mechanism of HLSC. Methods. Laser capture microdissection (LCM) was used to purify the target cells from 10 pairs of HLSC tissues and their matched NHBE, respectively. A stable-isotope labeled strategy using iTRAQ, followed by 2D-LC/Q-STAR mass spectrometry, was performed to separate and identify the differential expression proteins. Results. A total of 96 differential expression proteins in the LCM-purified HLSC and NBE were identified. Compared with NBE, 49 proteins were upregulated and 47 proteins were downregulated in HLSC. Furthermore, the expression levels of the differential proteins including HSPB1, CKB, SCCA1, S100A8, as well as S100A9 were confirmed by western blot and tissue microarray and were consistent with the results of quantitative proteomics. Conclusion. The different expression proteins in HLSC will provide scientific foundation for further study to explore the carcinogenic mechanism of HLSC