1 research outputs found
Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke
Overproduction
of reactive oxygen species by damaged mitochondria
after ischemia is a key factor in the subsequent cascade of damage.
Delivery of therapeutic agents to the mitochondria of damaged neurons
in the brain is a potentially promising targeted therapeutic strategy
for the treatment of ischemic stroke. In this study, we developed
a ceria nanoenzymes synergistic drug-carrying nanosystem targeting
mitochondria to address multiple factors of ischemic stroke. Each
component of this nanosystem works individually as well as synergistically,
resulting in a comprehensive therapy. Alleviation of oxidative stress
and modulation of the mitochondrial microenvironment into a favorable
state for ischemic tolerance are combined to restore the ischemic
microenvironment by bridging mitochondrial and multiple injuries.
This work also revealed the detailed mechanisms by which the proposed
nanodelivery system protects the brain, which represents a paradigm
shift in ischemic stroke treatment