GRB 211211A: a Neutron Star−-White Dwarf Merger?

The gamma-ray burst GRB 211211A and its associated kilonova-like emission were reported recently. A significant difference between this association event and GRB 170817A/AT 2017gfo is that GRB 211211A has a very long duration. In this paper, we show that this association event may arise from a neutron star$-$white dwarf (NS$-$WD) merger if a magnetar leaves finally in the central engine. Within the NS$-$WD merger, the main burst of GRB 211211A could be produced by magnetic bubble eruptions from toroidal magnetic field amplification of the pre-merger NS. This toroidal field amplification can be induced by the runaway accretion from the WD debris disc if the disc is in low initial entropy and efficient wind. While the extended emission of GRB 211211A is likely involved with magnetic propelling. The observed energetics and duration of the prompt emission of GRB 211211A can be fulfilled in comparison with those of accretion in hydrodynamical thermonuclear simulation, as long as the WD has a mass $\gtrsim1M_{\odot}$. Moreover, if the X-ray plateau in GRB afterglows is due to the magnetar spin-down radiation, GRB optical afterglows and kilonova-like emission can be well jointly modeled combining the standard forward shock with the radioactive decay power of $^{56}{\rm Ni}$ adding a rotational power input from the post-merger magnetar.Comment: Accepted by ApJ Letters. The accretion rate can be >0.01$M_{\odot}s^{-1}$ if the WD debris disc is in low initial entropy simulated by Kaltenborn et al. (2022). Main burst vs. extended emission: accretion vs. propelling. Kilonova-like emission: magnetar-fed $^{56}{\rm Ni}$ powe

Photospheric velocity evolution of SN 2020bvc: signature of rr-process nucleosynthesis from a collapsar

Whether binary neutron star mergers are the only astrophysical site of rapid neutron-capture process ($r$-process) nucleosynthesis remains unknown. Collapsars associated with long gamma-ray bursts (GRBs) and hypernovae are promising candidates. Simulations have shown that outflows from collapsar accretion disks can produce enough $r$-process materials to explain the abundances in the universe. However, there is no observational evidence to confirm this result at present. SN 2020bvc is a broad-lined type Ic (Ic-BL) supernova (SN) possibly associated with a low-luminosity GRB. Based on semi-analytic SN emission models with and without $r$-process materials, we perform a fitting to the multi-band light curves and photospheric velocities of SN 2020bvc. We find that in a $r$-process-enriched model the mixing of $r$-process materials slows down the photospheric recession and therefore matches the velocity evolution better. The fitting results show that $r$-process materials with mass of $\approx0.36~M_\odot$ and opacity of $\approx4~\rm cm^2~g^{-1}$ is needed to mix with about half of the SN ejecta. Our fitting results are weakly dependent on the nebular emission. Future statistical analysis of a sample of type Ic-BL SNe helps us understand the contribution of collapsars to the $r$-process abundance.Comment: 16 Pages, 9 Figures, 2 Tables, Accepted by ApJ

Pholidota chinensis alleviates azoxymethane/dextran sulfate sodium-induced colorectal carcinogenesis through inhibition of TLR4 and COX-2

Background: Inflammatory bowel disease (IBD) always progresses to colorectal cancer (CRC) which is the second most frequent cause of death by cancer. It is about 2% of population in the lifetime worldwide who at the risk for development of CRC. Oxaliplatin is an effective anticancer drug used for the treatment of advanced CRC; however, it always causes a robust painful neuropathy. Pholidota chinensis is a Chinese folk herbal medicine which was used for treatment of inflammation such as gastroenteritis, duodenal ulcer and bronchitis.Materials and Methods: The azoxymethane (AOM) and dextran sulfate sodium (DSS) were used to induce the colon tumor of mice. The effect of Pholidota chinensis on colon tumorigenesis was evaluated. Immunohistochemistry and semi-quantitative RT-PCR were used to detect the expression of toll-like receptor 4 (TLR4) and cyclooxygenase-2 (COX-2) in colon.Results: Pholidota chinensis can alleviate the colon tumorigenesis. The prevention effects of Pholidota chinensis are similar to oxaliplatin. Specifically, administration of Pholidota chinensis solution suppresses the expression of the proliferating cell nuclear antigen (PCNA), toll-like receptor 4 (TLR4) and cyclooxygenase-2 (COX-2).Conclusion: Our findings suggested that Pholidota chinensis participate in the regulation of colon cancer development through inhibiting the expression of TLR4 and COX-2.Keywords: Pholidota chinensis; colorectal cancer; Toll-like receptor 4; Cyclooxygenase-

An efficient and rapid method to detect and verify natural antisense transcripts of animal genes

AbstractHigh-throughput sequencing has identified a large number of sense-antisense transcriptional pairs, which indicates that these genes were transcribed from both directions. Recent reports have demonstrated that many antisense RNAs, especially lncRNA (long non-coding RNA), can interact with the sense RNA by forming an RNA duplex. Many methods, such as RNA-sequencing, Northern blotting, RNase protection assays and strand-specific PCR, can be used to detect the antisense transcript and gene transcriptional orientation. However, the applications of these methods have been constrained, to some extent, because of the high cost, difficult operation or inaccuracy, especially regarding the analysis of substantial amounts of data. Thus, we developed an easy method to detect and validate these complicated RNAs. We primarily took advantage of the strand specificity of RT-PCR and the single-strand specificity of S1 endonuclease to analyze sense and antisense transcripts. Four known genes, including mouse β-actin and Tsix (Xist antisense RNA), chicken LXN (latexin) and GFM1 (G elongation factor, mitochondrial 1), were used to establish the method. These four genes were well studied and transcribed from positive strand, negative strand or both strands of DNA, respectively, which represented all possible cases. The results indicated that the method can easily distinguish sense, antisense and sense-antisense transcriptional pairs. In addition, it can be used to verify the results of high-throughput sequencing, as well as to analyze the regulatory mechanisms between RNAs. This method can improve the accuracy of detection and can be mainly used in analyzing single gene and was low cost

Assessment of iris volume in glaucoma patients with type 2 diabetes mellitus by AS-OCT

AIM: To examine the change of iris volume measured by CASIA2 anterior segment optical coherence tomography (AS-OCT) in glaucoma patients with or without type 2 diabetes mellitus (T2DM) and explore if there is a correlation between hemoglobin A1c (HbA1c) level and iris volume. METHODS: In a cross-sectional study, 72 patients (115 eyes) were divided into two groups: primary open angle glaucoma (POAG) group (55 eyes) and primary angle-closure glaucoma (PACG) group (60 eyes). Patients in each group were separately classified into patients with or without T2DM. Iris volume and glycosylated HbA1c level were measured and analyzed. RESULTS: In the PACG group, diabetic patients' iris volume was significantly lower than those of non-diabetics (P=0.02), and there was a significant correlation between iris volume and HbA1c level in the PACG group (r=-0.26, P=0.04). However, diabetic POAG patients' iris volume was noticeably higher than those of non-diabetics (P=0.01), and there was a significant correlation between HbA1c level and iris volume (r=0.32, P=0.02). CONCLUSION: Diabetes mellitus impact iris volume size, as seen by increased iris volume in the POAG group and decreased iris volume in the PACG group. In addition, iris volume is significantly correlated with HbA1c level in glaucoma patients. These findings imply that T2DM may compromise iris ultrastructure in glaucoma patients

FY2014 Annual Report

Abstract Background This population-based study was designed to investigate whether consumption of sugar-sweetened beverages (SSB) is associated with lower serum total testosterone concentration in men 20–39 years old. Methods All data for this study were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2011–2012. The primary outcome was serum testosterone concentration, and main independent variable was SSB intake. Other variables included age, race/ethnicity, poverty/income ratio, body mass index (BMI), serum cotinine, heavy drinking, and physical activity. Results Among all subjects (N = 545), 486 (90.4%) had normal testosterone levels (defined as ≥231 ng/dL) and 59 (9.6%) had low testosterone levels (defined as < 231 ng/dL). Multivariate logistic regression revealed the odds of low testosterone was significantly greater with increasing SSB consumption (Q4 [≥442 kcal/day] vs. Q1 [≤137 kcal/day]), adjusted odds ratio [aOR] = 2.29, p = 0.041]. After adjusting for possible confounding variables, BMI was an independent risk factor for low testosterone level; subjects with BMI ≥ 25 kg/m2 had a higher risk of having a low testosterone level than those with BMI < 25 kg/m2 (aOR = 3.68, p = 0.044). Conclusion SSB consumption is significantly associated with low serum testosterone in men 20–39 years old in the United States