The distribution of 170 functional connections.

<p>The distribution of 170 functional connections.</p

The weight of 90 brain regions.

<p>The weight of 90 brain regions.</p

The accuracy of 500 SVMs.

<p>The accuracy of 500 SVMs.</p

Selecting "important features".

<p>Selecting "important features".</p

The optimal number of SVMs and optimal feature set.

<p>The optimal number of SVMs and optimal feature set.</p

The higher weight of brain regions.

<p>The higher weight of brain regions.</p

Basic characteristics of AD and HC.

<p>Basic characteristics of AD and HC.</p

The design of the random SVM cluster.

<p>The design of the random SVM cluster.</p

Table_1_NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients.doc

<p>The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on azathioprine (AZA) induced leukopenia in Chinese autoimmune patients. Among 87 enrolled patients, 23 (26.4%) had leukopenia. The NUDT15 R139C variant was associated with leukopenia (p = 1.86 × 10⁻⁷; OR: 7.59; 95% CI: 3.16–18.21). However, TPMT genotype was not shown to be correlated with the incidence of leukopenia (p = 0.95). There was no significant difference of 6-TGN concentration between patients with or without leukopenia (p = 0.15) and no association was found in patients with NUDT15 R139C variants alleles (p = 0.62). Finally, we found that the range of 6-TGN concentrations in autoimmune diseases was much lower than the established 6-TGN monitoring range for inflammatory bowel diseases. Therefore, the variant of NUDT15 R139C is strongly associated with AZA-induced leukopenia in Chinese patients with various autoimmune diseases such as systemic lupus erythematosus, Sjögren's syndrome, etc.</p

Phenolic and flavonoid compounds from the fruit shell of <i>Camellia oleifera</i>

A new phenolic compound oleiphenol (1), and a new dihydrochalcone oleifechalcone (2) along with seven known compounds (3-9) were isolated from the fruit shell of Camellia oleifera Abel. The planar structures of compounds 1 and 2 were determined on the basis of extensive spectroscopic analyses (IR, UV, NMR, and HR-ESI-MS) and comparison with literature data. The absolute configurations of the new structures were determined by ECD calculations and chemical methods. In addition, compounds 1-9 underwent a series of pharmacological activity tests, including cytotoxic, anti-inflammatory, anti-RSV and antioxidant activities.</p