Bis(μ-2-phenyl­quinoline-4-carboxyl­ato)-κ3 O,O′:O;κ3 O:O,O′-bis­[(2,2′-bipyridine-κ2 N,N′)(2-phenyl­quinoline-4-carboxyl­ato-κ2 O,O′)cadmium(II)]

The neutral binuclear title complex, [Cd2(C16H10NO2)4(C10H8N2)2], is centrosymmetric, with the inversion center generating the central (μ-O)2Cd2 bridge. The CdII ion is in a strongly distorted CdN2O5 penta­gonal-bipyramidal geometry, defined by two N atoms from one 2,2′-bipyridine ligand and five O atoms from three 2-phenyl­quinoline-4-carboxyl­ate ligands, one monodentate, two bidentate. Weak inter­molecular π–π inter­actions [centroid–centroid distance = 3.712 (3) Å] help to establish the packing of the structure

(μ-4,4′-Bipyridine-κ2 N:N′)bis­[bis­(N,N-dimethyl­dithio­carbamato-κ2 S,S′)zinc(II)]

The title dinuclear ZnII complex, [Zn2(C3H6NS2)4(C10H8N2)], is centrosymmetric; the mid-point of the C—C bond linking the two pyridine rings is located on an inversion center. The pyridine N atom coordinates to the ZnII cation, which is also chelated by two dimethyl­dithio­carbamate anions, giving a trigonal-bipyramidal ZnNS4 geometry. Weak inter­molecular C—H⋯S hydrogen bonding is present in the crystal structure

Bis(1,10-phenanthroline-κ2 N,N′)[2-(4-sulfonato­anilino)acetato-κO]copper(II) dihydrate

In the title compound, [Cu(C8H7NO5S)(C12H8N2)2]·2H2O, the CuII ion is coordinated by four N atoms from two 1,10-phenanthroline (phen) ligands and one O atom from a 2-(4-sulfonato­anilino)acetate (spia) ligand in a distorted square-pyramidal geometry. Inter­molecular N—H⋯O and O—H⋯O hydrogen bonds, as well as π–π inter­actions between phen ligands and between phen and spia ligands [centroid–centroid distances = 3.663 (3), 3.768 (3) and 3.565 (3) Å], result in a three-dimensional supra­molecular structure

Bis(μ-2-phenyl­quinoline-4-carboxyl­ato)bis­[aqua­(1,10-phenanthroline)(2-phenyl­quinoline-4-carboxyl­ato)manganese(II)] dihydrate

In the centrosymmetric dinuclear title complex, [Mn2(C16H10NO2)4(C12H8N2)2(H2O)2]·2H2O, the MnII cation is in a distorted octa­hedral coordination geometry defined by two N atoms from a 1,10-phenanthroline ligand, one water O atom and three O atoms from three 2-phenyl­quinoline-4-carboxyl­ate anions. A pair of 2-phenyl­quinoline-4-carboxyl­ate anions bridge two Mn cations, forming the dinuclear mol­ecule. An intra­moleculr O—H⋯O hydrogen bond occurs. Inter­molecular O—H⋯O and O—H⋯N hydrogen bonds are present in the crystal structure

Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population

<p>Abstract</p> <p>Background</p> <p>Bcl-3 as an oncoprotein is overexpressed in nasopharyngeal carcinoma (NPC). Nedd4 binding protein 2 (N4BP2), which is located in the NPC susceptibility locus, is a Bcl-3 binding protein. This study is aimed to explore the association between N4BP2 genetic polymorphism and the risk of NPC.</p> <p>Methods</p> <p>We performed a hospital-based case-control study, including 531 sporadic NPC and 480 cancer-free control subjects from southern China. PCR-sequencing was carried out on Exons, promoter region and nearby introns of the N4BP2 gene. The expression pattern of N4BP2 and Bcl-3 was also analyzed.</p> <p>Results</p> <p>We observed a statistically significant difference in haplotype blocks ATTA and GTTG between cases and controls. In addition, three novel SNPs were identified, two of which were in exons (loc123-e3l-snp2, position 39868005, A/G, Met171Val; RS17511668-SNP2, position 39926432, G/A, Glu118Lys), and one was in the intron6 (RS794001-SNP1, position 39944127, T/G). Moreover, N4BP2 was at higher levels in a majority of tumor tissues examined, relative to paired normal tissues.</p> <p>Conclusion</p> <p>These data suggest that haplotype blocks ATTA and GTTG of N4BP2 is correlation with the risk of sporadic nasopharyngeal carcinoma in the Southern Chinese population and N4BP2 has a potential role in the development of NPC.</p

Determination of heavy metals in chinese prickly ash from different production areas using inductively coupled plasma-mass spectrometry

Purpose: To determine the heavy metal content of Chinese prickly ash (CPA) produced in various areas of China.Methods: CPA samples collected from different production areas in China were subjected to microwave digestion, and the contents of copper (Cu), nickel (Ni), chromium (Cr), lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), tin (Sn), and antimony (Sb) were determined by inductively coupled plasma-mass spectrometry (ICP-MS).Results: Heavy metal levels in the CPA samples followed the order: Cu (3.29-24.17 mg/kg) &gt; Cr (0.04-7.33 mg/kg) &gt; Ni (0.88-6.86 mg/kg) &gt; Pb (0.00-3.84 mg/kg) &gt; As (0.0011-1.08 mg/kg) &gt; Cd (0.029-0.211 mg/kg) &gt; Sb (0.03-0.21 mg/kg) &gt; Sn (0.00-0.15 mg/kg) &gt; Hg (0.000-0.032 mg/kg). Metal-to-metal correlation studies showed that there were significant correlations between Cu-Cr (p = -4.02), Cu-Ni (p = 0.561), Cu-As (p = 0.554) and Ni-As (p = 0.428) at the 0.01 level. Also, some metal-to-metal correlations were observed in Pb-Cr (p = 0.351), Pb-Cu (p = -0.310), Sb-Cd (p = 0.322), Sb-Hg (p = 0.311) and Cd-Sn (p = 0.309) at the 0.05 level. The highest concentrations of Pb and As in CPA exceeded the maximum permissible limits in China. Based on current safety standards, the concentrations of heavy metals in these CPA samples mean they are safe for human consumption.Conclusions: The status of heavy metal concentrations of CPA should be further investigated in Sichuan, Shaanxi, Shanxi and Jiangsu. In addition, ICP-MS is a reliable and rapid technique for the determination of the heavy metals in CPA.Keywords: Chinese prickly ash, Heavy metals, Inductively-coupled plasma-mass spectrometry, Food safet

Cashmere growth control in Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 and decorin genes

Objective The study investigated the biological functions and mechanisms for controlling cashmere growth of Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) and decorin (DCN) genes. Methods cDNA library of Liaoning cashmere goat was constructed in early stages. OCIAD2 and DCN genes related to cashmere growth were identified by homology analysis comparison. The expression location of OCIAD2 and DCN genes in primary and secondary hair follicles (SF) was performed using in situ hybridization. The expression of OCIAD2 and DCN genes in primary and SF was performed using real-time polymerase chain reaction (PCR). Results In situ hybridization revealed that OCIAD2 and DCN were expressed in the inner root sheath of Liaoning cashmere goat hair follicles. Real-time quantitative PCR showed that these genes were highly expressed in SF during anagen, while these genes were highly expressed in primary hair follicle in catagen phase. Melatonin (MT) inhibited the expression of OCIAD2 and promoted the expression of DCN. Insulin-like growth factors-1 (IGF-1) inhibited the expression of OCIAD2 and DCN, while fibroblast growth factors 5 (FGF5) promoted the expression of these genes. MT and IGF-1 promoted OCIAD2 synergistically, while MT and FGF5 inhibited the genes simultaneously. MT+IGF-1/MT+FGF5 inhibited DCN gene. RNAi technology showed that OCIAD2 expression was promoted, while that of DCN was inhibited. Conclusion Activation of bone morphogenetic protein (BMP) signaling pathway up-regulated OCIAD2 expression and stimulated SF to control cell proliferation. DCN gene affected hair follicle morphogenesis and periodic changes by promoting transforming growth factor-β (TGF-β) and BMP signaling pathways. OCIAD2 and DCN genes have opposite effects on TGF-β signaling pathway and inhibit each other to affect the hair growth