The expression of let-7a and the effect of pri-let-7a-2 rs629367 polymorphism to its mature miRNA expression.

<p>Note: *means the variance analysis was used to calculate the difference between the expressions of three genotypes.</p

Kaplan–Meier survival curve analysis with the different genotypes of pri-let-7a-2 rs629367.

<p>A, CC vs. AA; B, CC vs. AA+CA.</p

Multivariate cox proportional hazard analysis for pri-let-7a-2 rs629367 polymorphisms.

<p>HR,hazard rate; CI,confidence interval; *, MST, median survival time (months). ^†, mean survival time was provided when MST could not be calculated. ^‡, Multivariate survival analysis was carried out by adding the SNP variable to the clinicopathological parameters with <i>P</i><0.05. NA: not available.</p

The association of four studied pri-miRNA polymorphism and risks of gastric cancer/atrophic gastritis*.

<p>Note: *using Logistic Regession adjusted by sex, age and <i>H.pylori</i> infection status; ^†means Hardy-Weinberg Equilibrium in population; CON: controls; AG: atrophic gastritis; GC: gastric cancer; NCBI Ref: the reference polymorphism frequencies in Beijing, China in NCBI database.</p

The effect of pri-let-7a rs629367 A/C SNP on the mature let-7a expression in vivo and vitro.

<p>A, The let-7a expression of different genotype of pri-let-7a-2 rs629367 in atrophic gastritis group in serum samples. B. the cell mature let-7a expression transinfected by different pri-let-7a-2 rs629367 plasmid. <b>*</b><b><i>P</i></b><b><0.001</b>.</p