Flow diagram showing the selection process of articles.

<p>RCT, randomized controlled trial.</p

Forest plot of distant metastasis for the MLND vs. MLNS groups.

<p>MLND, mediastinal lymph node dissection; MLNS, mediastinal lymph node sampling; RR, risk ratio; CI, confidence interval.</p

Risk of bias summary: review authors’ judgements about each methodological quality item for each included study.

<p>“+”, “−” or “?” reflected low risk of bias, high risk of bias and uncertain of bias respectively.</p

Mediastinal Lymph Node Dissection versus Mediastinal Lymph Node Sampling for Early Stage Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

<div><p>Objective</p><p>This systematic review and meta-analysis aimed to evaluate the overall survival, local recurrence, distant metastasis, and complications of mediastinal lymph node dissection (MLND) versus mediastinal lymph node sampling (MLNS) in stage I–IIIA non-small cell lung cancer (NSCLC) patients.</p><p>Methods</p><p>A systematic search of published literature was conducted using the main databases (MEDLINE, PubMed, EMBASE, and Cochrane databases) to identify relevant randomized controlled trials that compared MLND vs. MLNS in NSCLC patients. Methodological quality of included randomized controlled trials was assessed according to the criteria from the Cochrane Handbook for Systematic Review of Interventions (Version 5.1.0). Meta-analysis was performed using The Cochrane Collaboration’s Review Manager 5.3. The results of the meta-analysis were expressed as hazard ratio (HR) or risk ratio (RR), with their corresponding 95% confidence interval (CI).</p><p>Results</p><p>We included results reported from six randomized controlled trials, with a total of 1,791 patients included in the primary meta-analysis. Compared to MLNS in NSCLC patients, there was no statistically significant difference in MLND on overall survival (HR = 0.77, 95% CI 0.55 to 1.08; <i>P</i> = 0.13). In addition, the results indicated that local recurrence rate (RR = 0.93, 95% CI 0.68 to 1.28; <i>P</i> = 0.67), distant metastasis rate (RR = 0.88, 95% CI 0.74 to 1.04; <i>P</i> = 0.15), and total complications rate (RR = 1.10, 95% CI 0.67 to 1.79; <i>P</i> = 0.72) were similar, no significant difference found between the two groups.</p><p>Conclusions</p><p>Results for overall survival, local recurrence rate, and distant metastasis rate were similar between MLND and MLNS in early stage NSCLC patients. There was no evidence that MLND increased complications compared with MLNS. Whether or not MLND is superior to MLNS for stage II–IIIA remains to be determined.</p></div

Forest plot of overall survival for the MLND vs. MLNS groups.

<p>MLND, mediastinal lymph node dissection; MLNS, mediastinal lymph node sampling; HR, hazard ratio; CI, confidence interval.</p

Studies included in the meta-analysis.

<p><b>Abbreviations</b>: MLND, mediastinal lymph node dissection; MLNS, mediastinal lymph node sampling; NSCLC, non-small cell lung cancer; ND, not derived.</p><p>Studies included in the meta-analysis.</p

Forest plot of local recurrence for the MLND vs. MLNS groups.

<p>MLND, mediastinal lymph node dissection; MLNS, mediastinal lymph node sampling; RR, risk ratio; CI, confidence interval.</p

Josephson Effect in NbS₂ van der Waals Junctions

van der Waals (vdW) Josephson junctions can possibly accelerate the development of an advanced superconducting device that utilizes the unique properties of two-dimensional (2D) transition metal dichalcogenide (TMD) superconductors such as spin–orbit coupling and spin–valley locking. Here, we fabricate vertically stacked NbS2/NbS2 Josephson junctions using a modified all-dry transfer technique and characterize the device performance via systematic low-temperature transport measurements. The experimental results show that the superconducting transition temperature of the NbS2/NbS2 Josephson junction is 5.84 K, and the critical current density reaches 3975 A/cm2 at 2 K. Moreover, we extract a superconducting energy gap Δ = 0.58 meV, which is considerably smaller than that expected from the single band s-wave Bardeen–Cooper–Schrieffer (BCS) model (Δ = 0.89 meV)

General information of the included studies.

IntroductionLung cancer is the primary cause of cancer-related deaths worldwide, with high rates of morbidity and mortality. The most effective treatment for early stage (I-II) non-small cell lung cancer (NSCLC) is surgical resection. However, the extent of mediastinal lymph nodes removal required and the impact of their removal remains controversial. This systematic review and meta-analysis aimed to evaluate the postoperative complications in patients with stage I-II NSCLC who received mediastinal lymph node dissection (MLND) or mediastinal lymph node sampling (MLNS).Methods and analysisAccording to the predefined inclusion criteria, we will conduct a comprehensive search for randomized controlled trials (RCTs) and observational studies examining the postoperative complications of MLND compared to MLNS in patients with stage I-II NSCLC. The search will be performed across multiple databases including PubMed, Embase, the Cochrane Library, CNKI, WanFang, Sinomed, VIP, Duxiu, and Web of Science from inception to February 2024. Additionally, relevant literature references will be retrieved and hand searching of pertinent journals will be conducted. Screening, data extraction, and quality assessment will be performed by two independent reviewers. Review Manager 5.4 will be applied in analyzing and synthesizing. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to assess the quality of evidence for the whole RCTs and used Newcastle-Ottawa scale to assess the methodologic quality of observational studies.Ethics and disseminationThis study did not include personal information. Ethical approval was not required for this study. This study is based on a secondary analysis of the literature, so ethical review approval is not required. The final report will be published in a peer-reviewed journal.ConclusionThis systematic review will contribute to compare the safety and survival benefits of these two surgical techniques for the treatment of early stage NSCLC, to further guide the selection of surgical approaches.Trial registrationThe protocol of the systematic review has been registered on Open Science Framework, with a registration number of DOI https://doi.org/10.17605/OSF.IO/N2Y5D.</div

PRISMA-P-checklist.

IntroductionLung cancer is the primary cause of cancer-related deaths worldwide, with high rates of morbidity and mortality. The most effective treatment for early stage (I-II) non-small cell lung cancer (NSCLC) is surgical resection. However, the extent of mediastinal lymph nodes removal required and the impact of their removal remains controversial. This systematic review and meta-analysis aimed to evaluate the postoperative complications in patients with stage I-II NSCLC who received mediastinal lymph node dissection (MLND) or mediastinal lymph node sampling (MLNS).Methods and analysisAccording to the predefined inclusion criteria, we will conduct a comprehensive search for randomized controlled trials (RCTs) and observational studies examining the postoperative complications of MLND compared to MLNS in patients with stage I-II NSCLC. The search will be performed across multiple databases including PubMed, Embase, the Cochrane Library, CNKI, WanFang, Sinomed, VIP, Duxiu, and Web of Science from inception to February 2024. Additionally, relevant literature references will be retrieved and hand searching of pertinent journals will be conducted. Screening, data extraction, and quality assessment will be performed by two independent reviewers. Review Manager 5.4 will be applied in analyzing and synthesizing. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to assess the quality of evidence for the whole RCTs and used Newcastle-Ottawa scale to assess the methodologic quality of observational studies.Ethics and disseminationThis study did not include personal information. Ethical approval was not required for this study. This study is based on a secondary analysis of the literature, so ethical review approval is not required. The final report will be published in a peer-reviewed journal.ConclusionThis systematic review will contribute to compare the safety and survival benefits of these two surgical techniques for the treatment of early stage NSCLC, to further guide the selection of surgical approaches.Trial registrationThe protocol of the systematic review has been registered on Open Science Framework, with a registration number of DOI https://doi.org/10.17605/OSF.IO/N2Y5D.</div