32 research outputs found
Modulation, Bioinformatic Screening, and Assessment of Small Molecular Peptides Targeting the Vascular Endothelial Growth Factor Receptor
ï»żThree new species of non-marine ostracods (Crustacea, Ostracoda) from small water bodies of northern China
Three new species, Pseudocandona cheni sp. nov., Cyclocypris pangi sp. nov., and Tonnacypris rectangularis sp. nov., collected from northern China, are described in this study. Pseudocandona cheni, of the compressa group, is difficult to be distinguished from other members of the same group by carapace morphology alone, but can be readily recognised by the structure of the hemipenis comprised of a long lobe a, distally inflated lobe h, and exteriorly pointed lobe b, as well as thick trunks of the male fifth limb endopodites. Cyclocypris pangi, despite its similarity in carapace morphology to its congeners, can be identified based on the morphology of the hemipenis, which bears a slender, slightly curved lobe h, and an S-shaped process accompanying lobe b, in addition to the rectangular trunk of the male fifth limb endopodite. On the other hand, Tonnacypris rectangularis, described on the basis of females only, can be distinguished from other Tonnacypris Diebel & Pietrzeniuk, 1975 representatives by its distinct sub-rectangular carapace alone. Other differences include the length of the swimming setae, the length of the distal claws on the second antennae, and the morphology of the pincer organ on the seventh limb. This study contributes to the poorly known extant non-marine ostracod fauna of Inner Mongolia and Beijing, and generally to the central-eastern Palaearctic region. In addition, the known distribution range of Tonnacypris is extended eastwardly by T. rectangularis. The valve-morphology data are useful for identifying fossil/sub-fossil representatives
A Mathematical Modeling of Evaluating Chinaâs Construction Safety for Occupational Accident Analysis
China has seen a rapid increase in its construction industry in recent years; however, safety conditions of their workers have not improved owing to low education levels and increasing age trend of construction personnel. This study analyzed construction occupations in China from 2010 to 2018 using descriptive analysis, ANOVA and factor analysis. The results showed May, July and August as the deadliest months during the peak of construction activities in the year. No particular day was established as having a higher risk than other days in the week. The most vulnerable times of the day are from 9 AM to 10 AM and 2 PM to 4 PM. A mathematic modeling based on factor analysis, which is the construction safety evaluation score equation, was developed to illustrate regional distribution, and Qinghai Province ranked the worst in construction safety in China. Problems such as poor labor and environment safety management procedures and false reporting or concealed reporting of construction accidents were revealed. Suggestions for improving Chinaâs construction safety were also generated. This study enriched statistical analysis results of construction accidents in China and evaluation modeling with an abundant database will serve as a reference for stakeholders and researchers to improve the construction safety situation in China
Metrology and visualization analysis of literatures related to tumor immunotherapy based on CiteSpace
Abstract To explore the development of global tumor immunotherapy in the past 20âyears, and analyze the research status, hotspots and trends to provide theoretical support for subsequent research. CiteSpace 5.6.R2 software were used to analyze 290 articles related to tumor immunotherapy research from the Web of Science core data set from 2000 to 2019. CiteSpace was used to draw related visual maps and tables of coauthors, cooperating countries, cooperating institutions, literature and journal coâcitation, keyword coâoccurrence, and cluster analysis. The total amount of papers published in the field of tumor immunotherapy research has gradually increased. After receiving the Nobel Prize in Physiology or Medicine in 2018, the number of papers published in the field of research in tumor research reached 20. We found that the United States has the largest number of papers in all countries and China ranks 6. âProceedings of the National Academy of Sciences of the United States of America,â âJournal of Immunology,â âCancer Research,â âNew England Journal of Medicine,â âBloodâ is the top five core academic journals in this field. Cancer, disease, and tumor necrosis factor are the three keywords with the highest highlighting intensity. Comprehensive analysis shows that the coauthors, coâinstitutions, and coâcited journals of the literature are mostly concentrated in the United States. The rise of immunotherapy provides a new direction for tumor treatment. From 2018 to 2019, the number of literatures on tumor immunotherapy worldwide increased sharply. Immunotherapy combined with specific diseases is the current research frontier and hotspot
Distribution characteristics of pulverized coal and stressâgas pressureâtemperature response laws in coal and gas outburst under deep mining conditions
Abstract Deep mining will increase the likelihood of coal and gas outburst accidents and do harm to the safety of coal mining. In this study, a coal and gas outburst experiment under deep highâstress conditions was carried out and stressâgas pressureâtemperature response laws in coal and rock surrounding the burst hole were evaluated. The experimental results showed that the stress response around the burst hole was intense and stress variation decreased as distance from the position to burst port increased. The gas pressure in the coal decreased sharply and oscillated several times during the burst process. The maximum rebound range was 0.05âMPa during this process. The decreasing rate of gas pressure reduced with the increase of the positionâburst port distance. The temperature response near the burst port was stronger than peripheral area. The gas internal energy was still the main energy source of coal and gas outbursts, accounting for 75% of the total energy, and played a key role in the burst process. The contribution of elastic potential energy was 22% under deep highâstress conditions in this study. Based on the analysis of burst energy, the gas and stress were key factors of an outburst
Numerical Simulation Study on the Multi-Physical Field Response to Underground Coal and Gas Outburst under High Geo-Stress Conditions
Based on thermal–fluid–solid coupling law in coal and gas outburst, a multi-physical field numerical analysis model is built for the whole outburst process. The response laws of stress, gas pressure, temperature, and seepage in different areas and different time nodes around coal and rock mass in the coal and gas outburst under high stress condition are discussed. Research results show: Firstly, the stress response law of the coal and rock mass around the burst hole is initial vibration–sudden attenuation–late stability. Secondly, the gas pressure response law in different areas is that the gas pressure response rate decreases gradually with the increase of the distance from the outburst. Thirdly, the adsorbed gas contained in the broken coal near the outburst port is desorbed rapidly and expands to do work, and the temperature changes dramatically after outburst occurs. In contrast, with the increase of stress, the proportion of elastic potential in total coal and gas outburst energy increases, and the proportion of elastic potential is positively correlated with stress. The critical gas pressure under the energy condition of coal and gas outburst decreases with the increase of stress. It illustrates that the lower gas pressure can also meet the energy condition of coal and gas outburst under high stress
Tree stem extraction from TLS point-cloud data of natural forests based on geometric features and DBSCAN
Conventional methods for tree stem extraction from point-cloud data of natural forests suffer from problems of low accuracy and poor universality. In this article, an enhanced method is proposed for tree stem extraction from point-cloud data collected by terrestrial laser scanning (TLS). First, principal component analysis is used to calculate the eigenvalues and eigenvectors of the point-cloud data, and an information entropy criterion is minimized in order to achieve the best neighbourhood scale selection. Then, three-dimensional spatial geometric forest features are combined with the Z-axis component of the normal vector. These geometric features are used for rough extraction of tree stem points, while a large number of non-stem points is filtered out by thresholding. Finally, the DBSCAN algorithm is used to achieve accurate extraction of tree stem points. The proposed method for tree stem detection and extraction is experimentally evaluated in the case of two representative natural forest plots of Pinus densata Mast. and Picea asperata Mast. in the Shangri-La City in China. All stem points in these two plots were detected and extracted with a reference method to create a ground-truth dataset. Correlation analysis was carried out between the stem points extracted by the proposed and reference methods for the two plots. This analysis resulted in an R2 value of 0.990 for the Pinus densata Mast. sample plot, and an R2 value of 0.982 for the Picea asperata Mast. sample plot which has a more complex growth environment
Numerical Simulation Study on the Multi-Physical Field Response to Underground Coal and Gas Outburst under High Geo-Stress Conditions
Based on thermalâfluidâsolid coupling law in coal and gas outburst, a multi-physical field numerical analysis model is built for the whole outburst process. The response laws of stress, gas pressure, temperature, and seepage in different areas and different time nodes around coal and rock mass in the coal and gas outburst under high stress condition are discussed. Research results show: Firstly, the stress response law of the coal and rock mass around the burst hole is initial vibrationâsudden attenuationâlate stability. Secondly, the gas pressure response law in different areas is that the gas pressure response rate decreases gradually with the increase of the distance from the outburst. Thirdly, the adsorbed gas contained in the broken coal near the outburst port is desorbed rapidly and expands to do work, and the temperature changes dramatically after outburst occurs. In contrast, with the increase of stress, the proportion of elastic potential in total coal and gas outburst energy increases, and the proportion of elastic potential is positively correlated with stress. The critical gas pressure under the energy condition of coal and gas outburst decreases with the increase of stress. It illustrates that the lower gas pressure can also meet the energy condition of coal and gas outburst under high stress