481 research outputs found
Private ownersâ propensity to engage in shared parking schemes under uncertainty:comparison of alternate hybrid expected utility-regret-rejoice choice models
To develop effective strategies for the supply of shared parking and study various theoretical choice models under uncertainty, this paper investigates private parking space ownersâ propensity to engage in shared parking schemes using a stated choice experiment that involves an uncertain key attribute. A hybrid expected utility-regret model incorporating rejoice is specified to explore the participation behavior. Equivalent models considering the perception of attribute differences are also estimated. Results show that socio-demographic characteristics, social influence, governmentâs role, media attention, platform fee, and revenues are all important factors explaining private parking ownersâ propensity to engage in shared parking schemes. Besides, the model incorporating all these components, including the emotions of regret and rejoice and the perception of attribute differences, yields the best results. These findings could help promote the policy development toward increasing peopleâs engagement in shared parking.</p
Analysis of Quality Influencing Factors and Coping Strategies in Site Construction Stage of Prefabricated Building
Limited to the current industry, the personnel, knowledge, and technology reserves of prefabricated buildings are not sufficient, which directly affects the engineering quality of prefabricated buildings. In particular, the quality control of the prefabricated building site construction stage is the most critical. In view of the on-site construction stage of prefabricated buildings, this paper sorts out the influencing factors of project quality from three aspects of personnel, technology and management, and from the three aspects of personnel quality, construction technology and whole process management, the coping strategies of engineering quality problems are put forward. It can effectively improve the detailed management and control of quality problems in the construction stage of the prefabricated building, and help the rapid development of the prefabricated building industry
Phonon chirality manipulation mechanism in TMD interlayer-sliding ferroelectrics
As an ideal platform, both the theoretical prediction and first experimental
verification of chiral phonons are based on transition-metal dichalcogenide
materials. The manipulation of phonon chirality in these materials will have a
profound impact on the study of chiral phonons. In this work, we utilize the
sliding ferroelectric mechanism to study the phonon chirality manipulation
mechanism in transition-metal dichalcogenide materials. Based on
first-principles calculations, we study the different effects of interlayer
sliding on the phonon properties in bilayer and four-layer MoS sliding
ferroelectrics. We find that sliding can regulate phonon chirality and Berry
curvature, which further affects the phonon angular momentum and magnetization
under a temperature gradient and the phonon Hall effect under a magnetic field.
Our work connects two emerging fields and opens up a new route to manipulate
phonon chirality in transition-metal dichalcogenide materials through the
sliding ferroelectric mechanism.Comment: 15 pages, 4 figure
Characteristics of Pollen from Transgenic Lines of Apple Carrying the Exogenous CpTI Gene
AbstractIt is fundamental for gene transformation and ecosystem hazard evaluation to study the pollen characteristics of transgenic plants. In this research, the characteristics of pollen from 7- or 8-year-old transgenic apple plants carrying an exogenous CpTI gene were analyzed. The results showed that there was no significant difference in terms of size, morphology, or exine ornamentation between the pollen of the transgenic plants and the non-transgenic control. However, the transgenic plants had more abnormal pollen grains. Of the 13 transgenic lines tested, 12 had a significantly lower amount of pollen and six exhibited a significantly lower germination rate when cultured in vitro. The pollen viability of three transgenic lines was determined, with two showing significantly lower viability than the control. The transgenic Gala apple pollen grains germinated normally via controlled pollination on Fuji apple stigmas. However, the pollen tubes extended relatively slowly during the middle and late development stages, and another 8h were needed to reach the ovules compared with the control. The gibberellic acid concentration in transgenic Gala apple flowers was lower than in the non-transgenic control during all development stages tested. The abscisic acid concentration in the transgenic flowers was lower during the pink stage, and higher during the ball and fully open stages. Microscopic observation of the anther structure showed no difference. The tapetum of the pollen sac wall in transgenic plants decomposed late and affected pollen grain development, which could be one of the reasons for the lower number of pollen grains and poor viability in the transgenic plants
Quantitative susceptibility mapping using multi-channel convolutional neural networks with dipole-adaptive multi-frequency inputs
Quantitative susceptibility mapping (QSM) quantifies the distribution of magnetic susceptibility and shows great potential in assessing tissue contents such as iron, myelin, and calcium in numerous brain diseases. The accuracy of QSM reconstruction was challenged by an ill-posed field-to-susceptibility inversion problem, which is related to the impaired information near the zero-frequency response of the dipole kernel. Recently, deep learning methods demonstrated great capability in improving the accuracy and efficiency of QSM reconstruction. However, the construction of neural networks in most deep learning-based QSM methods did not take the intrinsic nature of the dipole kernel into account. In this study, we propose a dipole kernel-adaptive multi-channel convolutional neural network (DIAM-CNN) method for the dipole inversion problem in QSM. DIAM-CNN first divided the original tissue field into high-fidelity and low-fidelity components by thresholding the dipole kernel in the frequency domain, and it then inputs the two components as additional channels into a multichannel 3D Unet. QSM maps from the calculation of susceptibility through multiple orientation sampling (COSMOS) were used as training labels and evaluation reference. DIAM-CNN was compared with two conventional model-based methods [morphology enabled dipole inversion (MEDI) and improved sparse linear equation and least squares (iLSQR) and one deep learning method (QSMnet)]. High-frequency error norm (HFEN), peak signal-to-noise-ratio (PSNR), normalized root mean squared error (NRMSE), and the structural similarity index (SSIM) were reported for quantitative comparisons. Experiments on healthy volunteers demonstrated that the DIAM-CNN results had superior image quality to those of the MEDI, iLSQR, or QSMnet results. Experiments on data with simulated hemorrhagic lesions demonstrated that DIAM-CNN produced fewer shadow artifacts around the bleeding lesion than the compared methods. This study demonstrates that the incorporation of dipole-related knowledge into the network construction has a potential to improve deep learning-based QSM reconstruction
Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line
Oridonin, a diterpenoid isolated from Rabdosia rubescencs, has been reported to have antitumor effects. However, low solubility has limited its clinical applications. Preparation of drugs in the form of nanosuspensions is an extensively utilized protocol. In this study, we investigated the anticancer activity of oridonin and oridonin nanosuspension on human pancreatic carcinoma PANC-1 cells. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to investigate the effect of oridonin on cell growth. Propidium iodide and Hoechst 33342 staining were used to detect morphologic changes. The percentage of apoptosis and cell cycle progression was determined by flow cytometric method staining with propidium iodide. Annexin V-fluorescein isothiocyanate (FITC)/PI staining was used to evaluate cell apoptosis by flow cytometry. Caspase-3 activity was measured by spectrophotometry. The apoptotic and cell cycle protein expression were determined by Western blot analysis. Both oridonin and oridonin nanosuspension induced apoptosis and G2/M phase cell cycle arrest, and the latter had a more significant cytotoxic effect. The ratio of Bcl-2/Bax protein expression was decreased and caspase- 3 activity was stimulated. The expression of cyclin B1 and p-cdc2 (T161) was suppressed. Our results showed that oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line
Sino-European Transcontinental Basic and Clinical High-Tech Acupuncture StudiesâPart 2: Acute Stimulation Effects on Heart Rate and Its Variability in Patients with Insomnia
This second part of a series of Sino-European high-tech acupuncture studies describes the first clinical transcontinental teleacupuncture measurements in patients with insomnia. Heart rate (HR) and heart rate variability (HRV) measurements in 28 patients (mean age ± SD: 41.9 ± 14.6 years) were performed under standardized conditions in Harbin, China, and the data analysis was performed in Graz, Austria. Similar to the first part of the series, the electrocardiograms (ECGs) were recorded by an HRV Medilog AR12 system during acupuncture of the Shenmen point (HT7) on the left hand. HR decreased significantly (P < 0.001) during and after acupuncture stimulation of the HT7 acupuncture point. Total HRV increased significantly (P < 0.05) immediately after acupuncture stimulation, but there was no long-lasting effect. The values of the low-frequency (LF) and high-frequency (HF) band increased significantly after the stimulation compared to baseline values; however, the LF/HF ratio showed no significant changes. Together with the results of previous studies, the present results can serve as a solid basis for further development of acupressure or acupuncture stimulation equipment for complementary use in treating insomnia
Empowering Many, Biasing a Few: Generalist Credit Scoring through Large Language Models
In the financial industry, credit scoring is a fundamental element, shaping
access to credit and determining the terms of loans for individuals and
businesses alike. Traditional credit scoring methods, however, often grapple
with challenges such as narrow knowledge scope and isolated evaluation of
credit tasks. Our work posits that Large Language Models (LLMs) have great
potential for credit scoring tasks, with strong generalization ability across
multiple tasks. To systematically explore LLMs for credit scoring, we propose
the first open-source comprehensive framework. We curate a novel benchmark
covering 9 datasets with 14K samples, tailored for credit assessment and a
critical examination of potential biases within LLMs, and the novel instruction
tuning data with over 45k samples. We then propose the first Credit and Risk
Assessment Large Language Model (CALM) by instruction tuning, tailored to the
nuanced demands of various financial risk assessment tasks. We evaluate CALM,
and existing state-of-art (SOTA) open source and close source LLMs on the build
benchmark. Our empirical results illuminate the capability of LLMs to not only
match but surpass conventional models, pointing towards a future where credit
scoring can be more inclusive, comprehensive, and unbiased. We contribute to
the industry's transformation by sharing our pioneering instruction-tuning
datasets, credit and risk assessment LLM, and benchmarks with the research
community and the financial industry
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