21 research outputs found
DNS: A multi-scale deconvolution semantic segmentation network for joint detection and segmentation
Real-time semantic segmentation has become crucial in many applications such as medical image analysis and autonomous driving. In this paper, we introduce a single semantic segmentation network, called DNS, for joint object detection and segmentation task. We take advantage of multi-scale deconvolution mechanism to perform real time computations. To this goal, down-scale and up-scale streams are utilized to combine the multi-scale features for the final detection and segmentation task. By using the proposed DNS, not only the tradeoff between accuracy and cost but also the balance of detection and segmentation performance are settled. Experimental results for PASCAL VOC datasets show competitive performance for joint object detection and segmentation task
Chirality selective magnon-phonon hybridization and magnon-induced chiral phonons in a layered zigzag antiferromagnet
Two-dimensional (2D) magnetic systems possess versatile magnetic order and
can host tunable magnons carrying spin angular momenta. Recent advances show
angular momentum can also be carried by lattice vibrations in the form of
chiral phonons. However, the interplay between magnons and chiral phonons as
well as the details of chiral phonon formation in a magnetic system are yet to
be explored. Here, we report the observation of magnon-induced chiral phonons
and chirality selective magnon-phonon hybridization in a layered zigzag
antiferromagnet (AFM) FePSe. With a combination of magneto-infrared and
magneto-Raman spectroscopy, we observe chiral magnon polarons (chiMP), the new
hybridized quasiparticles, at zero magnetic field. The hybridization gap
reaches 0.25~meV and survives down to the quadrilayer limit. Via first
principle calculations, we uncover a coherent coupling between AFM magnons and
chiral phonons with parallel angular momenta, which arises from the underlying
phonon and space group symmetries. This coupling lifts the chiral phonon
degeneracy and gives rise to an unusual Raman circular polarization of the
chiMP branches. The observation of coherent chiral spin-lattice excitations at
zero magnetic field paves the way for angular momentum-based hybrid phononic
and magnonic devices
Immune Checkpoint in Glioblastoma: Promising and Challenging
Glioblastoma (GBM) is a severe malignant brain cancer with poor overall survival. Conventional intervention remains dismal to prevent recurrence and deterioration of GBM cell. Recent years have witnessed exciting breakthroughs in novel immune strategies, especially checkpoint inhibitors, some of which have become adjuvant setting after standard of care in melanoma. Several clinical trials of checkpoint inhibitors are ongoing in glioblastoma and other brain carcinomas. Plus, synergistic combinations of checkpoint inhibitors with conventional therapy strategies—radiotherapy, temozolomide, bevacizumab, and corticosteroids are now being exploited and applied in clinical settings. This review highlights the recent developments of checkpoints in GBM immunotherapy to provide a brief and comprehensive review of current treatment options. Furthermore, we will discuss challenges remained, such as unique immune system of central nervous system (CNS), immune-related toxicities, synergies, and adverse interactions of combination therapies
Non-Thermal Emergence of an Orbital-Selective Mott Phase in FeTeSe
Electronic correlation is of fundamental importance to high temperature
superconductivity. Iron-based superconductors are believed to possess moderate
correlation strength, which combined with their multi-orbital nature makes them
a fascinating platform for the emergence of exotic phenomena. A particularly
striking form is the emergence of an orbital selective Mott phase, where the
localization of a subset of orbitals leads to a drastically reconstructed Fermi
surface. Here, we report spectroscopic evidence of the reorganization of the
Fermi surface from FeSe to FeTe as Se is substituted by Te. We uncover a
particularly transparent way to visualize the localization of the
electron orbital through the suppression of its hybridization with the more
coherent electron orbitals, which leads to a redistribution of the
orbital-dependent spectral weight near the Fermi level. These noteworthy
features of the Fermi surface are accompanied by a divergent behavior of a band
renormalization in the orbital. All of our observations are further
supported by our theoretical calculations to be salient spectroscopic
signatures of such a non-thermal evolution from a strongly correlated metallic
phase towards an orbital-selective Mott phase in FeTeSe as Se
concentration is reduced.Comment: 11 pages, 5 figure
Research on the Rational Design Method of Strength Reinforcement for Thin-Walled Structure Based on Limit Load Analysis
Thin-walled structures subjected to internal or external pressure usually need to be reinforced with ribs. The design of ribs is generally based on experiences in engineering, and the results are often very conservative. In this paper, an approach for the rational design of reinforced ribs on thin-walled structures is proposed based on the limit load analysis method, maximizing the limit load of the reinforced thin-walled structure or minimizing the weight of the reinforced ribs. Firstly, the limit load numerical analysis was conducted to study rib forms at the continuous and discontinuous regions of the structure and find the rational ribs which provide the most effective reinforcement for the structure. Then, using the proposed rib forms, an engine test cabin was re-designed based on the limit load analysis to verify the feasibility and effects of the rib design. The engine test cabin after the redesign of the rib plate can reach 98% of the limit load of the original test cabin while the weight of reinforcing ribs is only 62% of the weight of the original ones, which means that the reinforcement design approach based on the limit load analysis method and the rib forms proposed in this paper is effective and feasible, and can achieve a structural lightweight design
A Study of the Closed-Loop Supply Chain Coordination on Waste Glass Bottles Recycling
The recycling of waste products can sharply save manufacturing cost and improve the economic efficiency and corporate-reputation. It also has a great effect on the environment and resources protection. In the management of the closed-loop supply chain, the recycling of waste products and decision-making on pricing often directly affect the supply and demand of products and the operation efficiency of supply chain. Therefore, first we take waste glass bottles as an example and establish a mathematical model to solve the profit of manufacturers and retailers solely. Then, we analyzed whole supply chain profit under a dual-channel recycling condition which is directly recycled by consumers or by retailers. Finally, we concluded that no matter what product’s price, quality, profit, or operational efficiency of supply chain is, the overall recycling is better than the single node recycling model. Based on the analysis, we developed a new model to coordinate the profit of manufacturers and retailers in the supply chain with revenue-sharing contract. A numerical study shows that this approach is applicable and effective
A Panel of MicroRNAs as Diagnostic Biomarkers for the Identification of Prostate Cancer
Prostate cancer is the most common non-cutaneous cancer among men; yet, current diagnostic methods are insufficient, and more reliable diagnostic markers need to be developed. One answer that can bridge this gap may lie in microRNAs. These small RNA molecules impact protein expression at the translational level, regulating important cellular pathways, the dysregulation of which can exert tumorigenic effects contributing to cancer. In this study, high throughput sequencing of small RNAs extracted from blood from 28 prostate cancer patients at initial stages of diagnosis and prior to treatment was used to identify microRNAs that could be utilized as diagnostic biomarkers for prostate cancer compared to 12 healthy controls. In addition, a group of four microRNAs (miR-1468-3p, miR-146a-5p, miR-1538 and miR-197-3p) was identified as normalization standards for subsequent qRT-PCR confirmation. qRT-PCR analysis corroborated microRNA sequencing results for the seven top dysregulated microRNAs. The abundance of four microRNAs (miR-127-3p, miR-204-5p, miR-329-3p and miR-487b-3p) was upregulated in blood, whereas the levels of three microRNAs (miR-32-5p, miR-20a-5p and miR-454-3p) were downregulated. Data analysis of the receiver operating curves for these selected microRNAs exhibited a better correlation with prostate cancer than PSA (prostate-specific antigen), the current gold standard for prostate cancer detection. In summary, a panel of seven microRNAs is proposed, many of which have prostate-specific targets, which may represent a significant improvement over current testing methods