Effect of frequency coupling on stability analysis of a grid-connected modular multilevel converter system

Due to the internal dynamics of the modular multilevel converter (MMC), the coupling between the positive and negative sequences in impedance, which is defined as frequency coupling, inherently exists in MMC. Ignoring the frequency coupling of the MMC impedance model may lead to inaccurate stability assessment, and thus the multi-input multi-output (MIMO) impedance model has been developed to consider the frequency coupling effect. However, the generalized Nyquist criterion (GNC), which is used for the stability analysis of an MIMO model, is more complicated than the stability analysis method applied on single-input-single-output (SISO) models. Meanwhile, it is not always the case that the SISO model fails in the stability assessment. Therefore, the conditions when the MIMO impedance model needs to be considered in the stability analysis of an MMC system should be analyzed. This paper quantitatively analyzes the effect of frequency coupling on the stability analysis of grid-connected MMC, and clarifies the frequency range and grid conditions that the coupling effect required to be considered in the stability analysis. Based on the quantitative relations between the frequency coupling and the stability analysis of the grid-connected MMC system, a simple and accurate stability analysis method for the grid-connected MMC system is proposed, where the MIMO impedance model is applied when the frequency coupling has a significant effect and the SISO impedance model is used if the frequency coupling is insignificant

Neutron Activation Background in the NvDEx Experiment

An extremely low-background environment is a crucial requirement for any neutrinoless double beta decay experiment. Neutrons are very difficult to stop, because they can pass through the shields and activate nuclei in the detector, even inside the fiducial volume itself. Using Geant4 simulations we have studied the neutron background for N$\nu$DEx-100 and the most efficient way to reduce it. Using a 60 cm thick external HDPE shield the neutron background can be reduced down to $0.24\pm 0.06$ events/year, lower than the background rate due to natural radioactivity (0.42 events/year), which was used as a benchmark for these calculations. The amount of shielding material needed can be significantly reduced by placing HDPE in the empty space between the lead shield and the steel vessel; in this way, it is sufficient to add 20 cm external HDPE shield to reduce the neutron background down to $0.15\pm0.05$ events/year.Comment: 13 pages, 11 figure

Potential implications of SARS-CoV-2 oral infection in the host microbiota

The oral cavity, as the entry point to the body, may play a critical role in the pathogenesis of SARS-CoV-2 infection that has caused a global outbreak of the coronavirus disease 2019 (COVID-19). Available data indicate that the oral cavity may be an active site of infection and an important reservoir of SARS-CoV-2. Considering that the oral surfaces are colonized by a diverse microbial community, it is likely that viruses have interactions with the host microbiota. Patients infected by SARS-CoV-2 may have alterations in the oral and gut micro-biota, while oral species have been found in the lung of COVID-19 patients. Furthermore, interactions between the oral, lung, and gut microbiomes appear to occur dynamically whereby a dysbiotic oral microbial community could influence respiratory and gastrointest-inal diseases. However, it is unclear whether SARS-CoV-2 infection can alter the local home-ostasis of the resident microbiota, actively cause dysbiosis, or influence cross-body sites interactions. Here, we provide a conceptual framework on the potential impact of SARS- CoV-2 oral infection on the local and distant microbiomes across the respiratory and gastro-intestinal tracts (‘oral-tract axes’), which remains largely unexplored. Studies in this area could further elucidate the pathogenic mechanism of SARS-CoV-2 and the course of infection as well as the clinical symptoms of COVID-19 across different sites in the human host

Double-Carrier Phase-Disposition Pulse Width Modulation Method for Modular Multilevel Converters

Modular multilevel converters (MMCs) have become one of the most attractive topologies for high-voltage and high-power applications. A double-carrier phase disposition pulse width modulation (DCPDPWM) method for MMCs is proposed in this paper. Only double triangular carriers with displacement angle are needed for DCPDPWM, one carrier for the upper arm and the other for the lower arm. Then, the theoretical analysis of DCPDPWM for MMCs is presented by using a double Fourier integral analysis method, and the Fourier series expression of phase voltage, line-to-line voltage and circulating current are deduced. Moreover, the impact of carrier displacement angle between the upper and lower arm on harmonic characteristics is revealed, and further the optimum displacement angles are specified for the circulating current harmonics cancellation scheme and output voltage harmonics minimization scheme. Finally, the proposed method and theoretical analysis are verified by simulation and experimental results

VEGF Is Involved in the Increase of Dermal Microvascular Permeability Induced by Tryptase

Tryptases are predominantly mast cell-specific serine proteases with pleiotropic biological activities and play a critical role in skin allergic reactions, which are manifested with rapid edema and increases of vascular permeability. The exact mechanisms of mast cell tryptase promoting vascular permeability, however, are unclear and, therefore, we investigated the effect and mechanism of tryptase or human mast cells (HMC-1) supernatant on the permeability of human dermal microvascular endothelial cells (HDMECs). Both tryptase and HMC-1 supernatant increased permeability of HDMECs significantly, which was resisted by tryptase inhibitor APC366 and partially reversed by anti-VEGF antibody and SU5614 (catalytic inhibitor of VEGFR). Furthermore, addition of tryptase to HDMECs caused a significant increase of mRNA and protein levels of VEGF and its receptors (Flt-1 and Flk-1) by Real-time RT-PCR and Western blot, respectively. These results strongly suggest an important role of VEGF on the permeability enhancement induced by tryptase, which may lead to novel means of controlling allergic reaction in skin