Learning image context for segmentation of the prostate in CT-guided radiotherapy

Accurate segmentation of prostate is the key to the success of external beam radiotherapy of prostate cancer. However, accurate segmentation of prostate in computer tomography (CT) images remains challenging mainly due to three factors: (1) low image contrast between the prostate and its surrounding tissues, (2) unpredictable prostate motion across different treatment days, and (3) large variations of intensities and shapes of bladder and rectum around the prostate. In this paper, an online-learning and patient-specific classification method based on the location-adaptive image context is presented to deal with all these challenging issues and achieve the precise segmentation of prostate in CT images. Specifically, two sets of location-adaptive classifiers are placed, respectively, along the two coordinate directions of the planning image space of a patient, and further trained with the planning image and also the previous-segmented treatment images of the same patient to jointly perform prostate segmentation for a new treatment image (of the same patient). In particular, each location-adaptive classifier, which itself consists of a set of sequential sub-classifiers, is recursively trained with both the static image appearance features and the iteratively-updated image context features (extracted at different scales and orientations) for better identification of each prostate region. The proposed learning-based prostate segmentation method has been extensively evaluated on 161 images of 11 patients, each with more than 9 daily treatment 3D CT images. Our method achieves the mean Dice value 0.908 and the mean ± SD of average surface distance (ASD) value 1.40 ± 0.57 mm. Its performance is also compared with three prostate segmentation methods, indicating the best segmentation accuracy by the proposed method among all methods under comparison

Excessive miR-152-3p Results in Increased BAFF Expression in SLE B-Cells by Inhibiting the KLF5 Expression

The increased BAFF expression in B-cells of patients with systemic lupus erythematosus (SLE) is associated with B-cell hyperstimulation and T-cell hyperactivity, but the underlying mechanisms are still unclear. This study aimed to uncover the mechanisms that regulate the BAFF expression in SLE B-cells. The results demonstrated that the expression of miR-152-3p was significantly increased in SLE B-cells compared with normal controls. This study confirmed that Kruppel-like factor 5 (KLF5) was a direct target of miR-152-3p, and it could bind to the promoter region of BAFF and inhibit its expression in B-cells. The upregulation of miRNA-152-3p expression decreased the KLF5 expression and increased the BAFF expression in SLE B-cells. Knockdown of miR-152-3p expression inhibited the self-reactivity of SLE B-cells, thereby reducing the autoantibody production. The increased miR-152-3p expression in SLE B-cells led to an increase in BAFF expression by inhibiting KLF5 expression. These factors caused B-cell self-reactivity and autoantibody production, allowing participation in the disease process of SLE

An experimental investigation of properties of Q345 steel pipe at elevated temperatures

This paper presents the results of an extensive experimental investigation of the thermal and mechanical properties of Q345 steel pipe at elevated temperatures using both the steady-state and transient-state test methods. Under these two test conditions, the thermal expansion coefficient, yield strength and elastic modulus of the specimens at different temperatures were measured. The tested results indicate that both the yield strength and elastic modulus decrease gradually with increasing temperature. However, at the same temperature, both the yield strength and elastic modulus tested using the steady-state test are higher than those tested using the transient-state test. Hence, it is less safe to use the material properties tested using the steady-state test for fire resistance design of the steel structure. Based on the transient-state test results, the models of the mechanical properties of Q345 steel pipe at elevated temperatures were proposed. These models can be used for the design and analysis of Q345 steel pipe structures under fire conditions.2012 Specialized Research Fund for the Doctoral Programme of Higher Education of China (Grant No. 20120095110027)

Testing and numerical simulation of concrete-filled 6061-T6 aluminum tubular stub columns

In this study, the axial compressive behaviour and design of circular and square concrete-filled 6061-T6 aluminum tubular (CFAT) stub columns were examined. The failure modes of the specimens and the relationship between load and axial displacement were reported. The test results demonstrate that, in comparison to square aluminum outer tubes, circular tubes can offer a better restraining effect on the core concrete. The failure modes of circular CFAT specimens were directly linked to the diameter-thick ratio. For circular CFAT specimens, shear damage of concrete was observed for specimens with the diameter-thick ratio (D/t) of 53.3, accompanied by local buckling and longitudinal tearing of the aluminum tube. The failure mode for circular specimens with the D/t of 16 was an overall waist drum deformation followed by an interior concrete crushing failure. For square CFAT specimens, the failure mode was generally local buckling exhibited by corner buckling and rip of the aluminum tube, and cracking and crushing of the concrete infill. Finally, a comparative analysis of the applicability of existing design approaches for determining the load-bearing capacity of concrete-filled steel tubular columns to CFAT columns was conducted

Experimental study on eccentric compressive behaviors of 6061-T6 aluminum tubular long columns filled with concrete

In this paper, eccentric compressive experiments of 12 circular and 6 square concrete-filled 6061-T6 aluminum tubular (CFAT) long columns were carried out. The influence of the section form, thickness of aluminum tube, slenderness ratio, and eccentricity on the flexural performance of CFAT long columns was investigated. The results showed that all the specimens exhibited flexural-dominated failure. The variation of eccentricity had little impact on the overall failure mode of the aluminum tube, while it dramatically influenced the failure mode of the internal concrete. The internal concrete failed in concrete crushing for all the square columns, while it remained intact for the circular columns. This indicates that circular tubes provide a better constraint effect on the internal concrete, there by increasing the ultimate strain of concrete under compression. It was also found that the increase of eccentricity leads to the weakening of the confinement afforded to the internal concrete, while the increase of slenderness ratio has no obvious effect on the restraining effect. Finally, the applicability of current design provisions for concrete-filled steel tubular (CFST) long columns to CFAT long columns was evaluated, and design suggestions were proposed

The behaviour of the power transmission tower subjected to horizontal support’s movements

In this paper, two half-scaled test tower models for a typical 110 kV single-circuit power transmission tower were designed and fabricated. The scaled test tower models were tested under the horizontal support’s stretching (tensile) and compressive movements with the normal working loading conditions. The deformations of the tested tower models and stresses within the different bracing members were fully measured. A large amount of comprehensive test data was generated. Also a finite element (FE) model using the software ANSYS was developed and validated by the test data. The research indicated that the designed half-scaled test tower model can reasonably represent the behaviour of the whole transmission tower under the horizontal support’s movements. The magnitude of the stresses was reduced from the bracing members at lower part to the bracing members at higher part of the tower. The effect of the ground surface deformations is more significant on the truss members closed to the supports. Hence, for the design of transmission tower against the horizontal support’s movements, it is important to reduce the slenderness of those bracing members.This research was supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions. The authors gratefully appreciate this support