Printing surface charge as a new paradigm to program droplet transport

Directed, long-range and self-propelled transport of droplets on solid surfaces, especially on water repellent surfaces, is crucial for many applications from water harvesting to bio-analytical devices. One appealing strategy to achieve the preferential transport is to passively control the surface wetting gradients, topological or chemical, to break the asymmetric contact line and overcome the resistance force. Despite extensive progress, the directional droplet transport is limited to small transport velocity and short transport distance due to the fundamental trade-off: rapid transport of droplet demands a large wetting gradient, whereas long-range transport necessitates a relatively small wetting gradient. Here, we report a radically new strategy that resolves the bottleneck through the creation of an unexplored gradient in surface charge density (SCD). By leveraging on a facile droplet printing on superamphiphobic surfaces as well as the fundamental understanding of the mechanisms underpinning the creation of the preferential SCD, we demonstrate the self-propulsion of droplets with a record-high velocity over an ultra-long distance without the need for additional energy input. Such a Leidenfrost-like droplet transport, manifested at ambient condition, is also genetic, which can occur on a variety of substrates such as flexible and vertically placed surfaces. Moreover, distinct from conventional physical and chemical gradients, the new dimension of gradient in SCD can be programmed in a rewritable fashion. We envision that our work enriches and extends our capability in the manipulation of droplet transport and would find numerous potential applications otherwise impossible.Comment: 11 pages, 4 figure

Immune-mediated inflammatory diseases and risk of venous thromboembolism: A Mendelian randomization study

IntroductionImmune-mediated inflammatory diseases (IMIDs) have been associated with an increased risk of venous thromboembolism (VTE) in multiple observational studies. However, a direct causally relation between IMIDs and VTE remains unclear to date. Here, we used Mendelian randomization (MR) analysis to investigate causal associations between IMIDs and VTE.MethodsWe collected genetic data from published genome-wide association studies (GWAS) for six common IMIDs, specifically inflammatory bowel disease (IBD), Crohn’s disease (CD), ulcerative colitis (UC), rheumatoid arthritis (RA), psoriasis (PSO), and systemic lupus erythematosus (SLE); and summary-level data for VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) from the FinnGen database. Two-sample MR analysis using inverse variance weighting (IVW) was performed to identify causal associations between IMIDs and VTE/DVT/PE, and sensitivity analyses were implemented for robustness.ResultsIVW analysis showed a causal relationship between genetically predicted UC (one type of IBD) and the risk of VTE (OR = 1.043, 95% CI: 1.013-1.073, p = 0.004) and DVT (OR = 1.088, 95% CI: 1.043-1.136, p < 0.001), but we found no evidence of causality between UC and PE (OR = 1.029, 95% CI: 0.986-1.074, p = 0.19). In addition, no associations were observed between total IBD, CD, RA, SLE, or PSO and VTE/DVT/PE. Sensitivity analysis found no evidence for horizontal pleiotropy.ConclusionThis MR study provides new genetic evidence for the causal relationship between IMIDs and the risk of VTE. Our findings highlight the importance of active intervention and monitoring to mitigate VTE risk in patients with IBD, in particular those presenting with UC

The Protective Effect of Magnesium Lithospermate B on Hepatic Ischemia/Reperfusion via Inhibiting the Jak2/Stat3 Signaling Pathway

Acute inflammation is an important component of the pathogenesis of hepatic ischemia/reperfusion injury (HIRI). Magnesium lithospermate B (MLB) has strong neuroprotective and cardioprotective effects. The purpose of this study was to determine whether MLB had underlying protective effects against hepatic I/R injury and to reveal the potential mechanisms related to the hepatoprotective effects. In this study, we first examined the protective effect of MLB on HIRI in mice that underwent 1 h ischemia followed by 6 h reperfusion. MLB pretreatment alleviated the abnormal liver function and hepatocyte damage induced by I/R injury. We found that serum inflammatory cytokines, including IL-6, IL-1β, and TNF-α, were significantly decreased by MLB during hepatic ischemia/reperfusion (I/R) injury, suggesting that MLB may alleviate hepatic I/R injury via inhibiting inflammatory signaling pathways. Second, we investigated the protein level of p-Jak2/Jak2 and p-Stat3/Stat3 using Western blotting and found that MLB could significantly inhibit the activation of the Jak2/Stat3 signaling pathway, which was further verified by AG490 in a mouse model. Finally, the effect of MLB on the Jak2/Stat3 pathway was further assessed in an in vitro model of RAW 264.7 cells; 1 µg/ml LPS induced the secretion of inflammatory mediators, including IL-6, TNF-α, and activation of the Jak2/Stat3 signaling pathway. MLB significantly inhibited the abnormal secretion of inflammatory factors and the activation of the Jak2/Stat3 signaling pathway in RAW264.7 cells. In conclusion, MLB was found for the first time to reduce inflammation induced by hepatic I/R via suppressing the Jak2/Stat3 pathway

Research on the Modeling of Bending-Torsional Coupling and Vibration Characteristics of Planetary Roller Screw Mechanism

A general bending-torsional coupling dynamic model of the planetary roller screw mechanism is developed by the lumped mass method in this paper to analyze the vibration characteristics. Firstly, the components of the planetary roller screw mechanism are treated as lumped mass, and the meshing relationships are expressed by the spring element. Secondly, the natural vibration characteristics of the planetary roller screw mechanism are analyzed, and four vibration modes based on the bending-torsional coupling dynamic model are summarized: carrier mode, torsional mode, transverse mode and roller mode. This reveals the vibration characteristics when the two kinds of meshing pairs (thread pair and gear pair) come into meshing synchronously. Then, the relationships between the structural parameters and the natural frequency of each vibration mode are discussed. Finally, the matrix equation is simplified according to the characteristics of vibration mode, and the analytic expressions of natural frequency under carrier mode and roller mode are obtained

Resolution of deadlocks in a fine discrete floor field cellular automata model-modeling of turning and lateral movement at bottlenecks

For a parallel scheme, finer discretization of space in cellular automaton models of pedestrian dynamics can lead to new problems, e.g. the formation of deadlocks. In order to deal with such problems in the floor field cellular automata (FFCA) model, the turning and lateral movement of occupants at a bottleneck are considered. Simulations of the proposed model are found to fit well with experiments. The turning breaks the deadlock and releases the congestion at the bottleneck. The deadlock frequency decreases and the free travel time increases with the turning probability at the bottleneck. For slow lateral movement, pedestrians take more time to reach the exit, and the peak flow is first reached at a later time. As the discretization becomes finer, the crowd shape around the bottleneck changes gradually from semi-circle to semi-ellipse. Pedestrians in the finer discrete model seem to prefer queuing in a line rather than making a detour. The increase of lateral velocity may lead to more frequent conflicts among pedestrians

Combination therapy of targeting CD20 antibody and immune checkpoint inhibitor may be a breakthrough in the treatment of B-cell lymphoma

Background: CD20 is a membrane protein extensively expressed on the surface of B cells at various stages of development and differentiation. Herein, we conducted a bibliometrics analysis of the literature on CD20-targeting antibody therapy in lymphoma. Methods: A total of 6663 articles were downloaded from the web of science core collection (WOSCC) from 1999 to July 23, 2022. Bibliometric.com was used for citation and annual publications analysis. VOSviewer was used to map countries/institutions/authors/journals nodes and links, extract hotspot keywords, and analyze the time trend of keywords. Citespace was employed to recognize the turning points based on the centrality value of countries, define the topic distribution of academics according to the map of dual-map overlay of journals, and characterize the emerging topics or landmark articles in a field based on references citation bursts. Results: All articles were cited 225,032 times, averaging 33.77. The number of articles increased from 1999 to 2002, while the growth rate entered the platform after 2002. The USA was the most publication country, and China was the largest emerging country. Hotspots in this field still focus on the efficacy of rituximab in treating non-Hodgkin's lymphoma and the pathogenesis of lymphoma Application of generation CD-20 antibodies or molecule inhibitors in clinical research and cellular therapy/immunotherapy, such as CAR-T and PDL1/PD1 were the emerging research topics. Conclusion: This study provides essential information and the tendency of the CD20-targeting antibody therapy in lymphoma by using bibliometric and visual methods, which would provide helpful references for clinical experiments and basic scientific research

Does Income Inequality Impair Health? Evidence from Rural China

In the context of the Healthy China strategy and the targeted poverty alleviation policy, based on the survey data of 1710 apple planters in Shandong, Yunnan, Shaanxi, and Gansu provinces, we selected the Probit model and the mediating effect test model to analyze the impact of income inequality on the self-rated health of farmers in this paper. The main results are as follows: First, income inequality within villages and townships had a significant negative impact on self-rated health, with both showing inverted U-shaped relationships, while income inequality within counties had no significant impact on self-rated health. Second, income inequality can impact the health of farmers, in terms of tobacco and alcohol behaviors, social trust, and sense of relative deprivation, where the mediating effect ratio of these three factors combined accounted for 32.4% of the total effect. Furthermore, the effect of income inequality on health was heterogeneous among different income groups, where the negative impact of income inequality on the self-rated health of the high-income group was less than that of the low-income group, indicating that an increase in income inequality serves to aggravate the degree of health inequality. Therefore, the government should adopt differentiated policies to improve the health of farmers. In rural areas with high income inequality, the government should focus on increasing the income of low-income groups, guide them to develop a healthy lifestyle, improve their social trust, and reduce their sense of relative deprivation. In rural areas where incomes are generally low, the government should first guide qualified farmers to become rich, then encourage others to become rich later