Descriptions of daily HFMD cases, meteorological factors and air pollutants in the basin area of Sichuan Province from January 1, 2015, to December 31, 2017.

Descriptions of daily HFMD cases, meteorological factors and air pollutants in the basin area of Sichuan Province from January 1, 2015, to December 31, 2017.</p

The results of sensitivity analysis.

Table A. The results of overdispersion test for the HFMD series. Table B. Different confounder model settings. Table C. Different autoregressive term settings. Table D. The values of different knots of splines for the exposure -response structure of air pollutants. Table E. The QAICs of different knots of splines for the exposure -response structure of air pollutants. Fig A. The overall model fit of different values of the degrees of freedom of time splines. Fig B. The overall model fit of different model settings of temperature. Fig C. The overall model fit of different model settings of Humid. Fig D. The overall model fit of different model settings of sunshine hours. Fig E. The overall model fit of different model settings of wind velocity. Fig F. The overall model fit of different model settings of precipitation. Fig G. The autocorrelation analysis on the residuals of the HFMD cases. Fig H. The overall model fit of different autoregressive term settings. Fig I. The ACF and PACF analysis on the residuals of the HFMD cases after controlling autoregressive term. Fig J. The QAICs of different dfs of splines for lag-response structure of air pollutants. (DOCX)</p

<i>R2R3MYB</i> genes in Citrus.

<p><i>R2R3MYB</i> genes in Citrus.</p

ClustalW amino acid sequence alignment of 101 citrus R2R3-MYB domains.

<p>The shading of the alignment represents different degrees of conservation among sequences; the dark shading indicates identical residues, the light shading indicates conservative changes. The positions of the three a-helices that form each MYB repeat are marked as Helix 1 to Helix 3.</p

Schematic of the intron distribution patterns within the MYB domains of 101 CitMYBs.

<p>Alignment of the MYB domains is representative of 12 intron patterns, named from P1 to Pl2. The locations of introns are indicated by white triangles. The number within each triangle indicates the splicing phases: 0 refers to phase 0; 1 refers to phase 1; and 2 refers to phase 2. The number of CitMYB proteins with each pattern is shown on the right.</p

Phylogenetic relationships, intron pattern, expression pattern, and subgroup designations in R2R3MYB proteins from citrus.

<p>A, The neighbor-joining (NJ) tree based on the complete protein sequences of 101 CitMYBs and the bootstrap values less than 50 are not shown in NJ tree. The tree shows the 21 phylogenetic subgroups (C1–C21) marked with colored backgrounds. Twelve proteins did not fit well into clusters. B, The gene structure is presented by exon (black boxes) and intron (black line between the black boxes). The number indicated the phases of corresponding introns. C, The expression patterns of 101 CitMYB genes in different organs. The letter R above the column of expression data refers to root, L refers to leaf, F refers to flower and G refers to fruitlet.</p

All results of the tests of heterogeneity and effect modifiers of the air pollutant-HFMD relationship.

(DOCX)</p

Heterogeneity and effect modifiers of the relationships between pollutant concentrations and the number of HFMD cases.

Heterogeneity and effect modifiers of the relationships between pollutant concentrations and the number of HFMD cases.</p

Predicted air pollutant-HFMD associations considering effect modifiers at the 10th and 90th percentiles.

Predicted air pollutant-HFMD associations considering effect modifiers at the 10th and 90th percentiles.</p

The overall and city-specific cumulative-response curves of PM2.5-HFMD relationships and predicted PM2.5-HFMD association considering effect modifiers at the 10th and 90th percentiles.

(DOCX)</p