1,686 research outputs found
Rhizoma Atractylodis Macrocephalae—Assessing the influence of herbal processing methods and improved effects on functional dyspepsia
Background: The unique pharmaceutical methods for the processing of botanical drugs according to the theory of traditional Chinese medicine (TCM) affect clinical syndrome differentiation and treatment. The objective of this study was to comprehensively elucidate the principles and mechanisms of an herbal processing method by investigating the alterations in the metabolites of Rhizoma Atractylodis Macrocephalae (AMR) processed by Aurantii Fructus Immaturus (AFI) decoction and to determine how these changes enhance the efficacy of aqueous extracts in treating functional dyspepsia (FD).Methods: A qualitative analysis of AMR before and after processing was conducted using UPLC-Q-TOF-MS/MS, and HPLC was employed for quantitative analysis. A predictive analysis was then conducted using a network analysis strategy to establish a botanical drug–metabolite–target–disease (BMTD) network and a protein–protein interaction (PPI) network, and the predictions were validated using an FD rat model.Results: A total of 127 metabolites were identified in the processed AMR (PAMR), and substantial changes were observed in 8 metabolites of PAMR after processing, as revealed by the quantitative analysis. The enhanced aqueous extracts of processed AMR (PAMR) demonstrate improved efficacy in treating FD, which indicates that this processing method enhances the anti-inflammatory properties and promotes gastric motility by modulating DRD2, SCF, and c-kit. However, this enhancement comes at the cost of attenuating the regulation of motilin (MTL), gastrin (GAS), acetylcholine (Ach), and acetylcholinesterase (AchE).Conclusion: Through this series of investigations, we aimed to unravel the factors influencing the efficacy of this herbal formulation in improving FD in clinical settings
The CDEX-1 1 kg Point-Contact Germanium Detector for Low Mass Dark Matter Searches
The CDEX Collaboration has been established for direct detection of light
dark matter particles, using ultra-low energy threshold p-type point-contact
germanium detectors, in China JinPing underground Laboratory (CJPL). The first
1 kg point-contact germanium detector with a sub-keV energy threshold has been
tested in a passive shielding system located in CJPL. The outputs from both the
point-contact p+ electrode and the outside n+ electrode make it possible to
scan the lower energy range of less than 1 keV and at the same time to detect
the higher energy range up to 3 MeV. The outputs from both p+ and n+ electrode
may also provide a more powerful method for signal discrimination for dark
matter experiment. Some key parameters, including energy resolution, dead time,
decay times of internal X-rays, and system stability, have been tested and
measured. The results show that the 1 kg point-contact germanium detector,
together with its shielding system and electronics, can run smoothly with good
performances. This detector system will be deployed for dark matter search
experiments.Comment: 6 pages, 8 figure
Quantum Neuronal Sensing of Quantum Many-Body States on a 61-Qubit Programmable Superconducting Processor
Classifying many-body quantum states with distinct properties and phases of
matter is one of the most fundamental tasks in quantum many-body physics.
However, due to the exponential complexity that emerges from the enormous
numbers of interacting particles, classifying large-scale quantum states has
been extremely challenging for classical approaches. Here, we propose a new
approach called quantum neuronal sensing. Utilizing a 61 qubit superconducting
quantum processor, we show that our scheme can efficiently classify two
different types of many-body phenomena: namely the ergodic and localized phases
of matter. Our quantum neuronal sensing process allows us to extract the
necessary information coming from the statistical characteristics of the
eigenspectrum to distinguish these phases of matter by measuring only one
qubit. Our work demonstrates the feasibility and scalability of quantum
neuronal sensing for near-term quantum processors and opens new avenues for
exploring quantum many-body phenomena in larger-scale systems.Comment: 7 pages, 3 figures in the main text, and 13 pages, 13 figures, and 1
table in supplementary material
Experimental quantum computational chemistry with optimised unitary coupled cluster ansatz
Simulation of quantum chemistry is one of the most promising applications of
quantum computing. While recent experimental works have demonstrated the
potential of solving electronic structures with variational quantum eigensolver
(VQE), the implementations are either restricted to nonscalable (hardware
efficient) or classically simulable (Hartree-Fock) ansatz, or limited to a few
qubits with large errors for the more accurate unitary coupled cluster (UCC)
ansatz. Here, integrating experimental and theoretical advancements of improved
operations and dedicated algorithm optimisations, we demonstrate an
implementation of VQE with UCC for H_2, LiH, F_2 from 4 to 12 qubits. Combining
error mitigation, we produce high-precision results of the ground-state energy
with error suppression by around two orders of magnitude. For the first time,
we achieve chemical accuracy for H_2 at all bond distances and LiH at small
bond distances in the experiment. Our work demonstrates a feasible path towards
a scalable solution to electronic structure calculation, validating the key
technological features and identifying future challenges for this goal.Comment: 8 pages, 4 figures in the main text, and 29 pages supplementary
materials with 16 figure
Direct Measurements of the Branching Fractions for and and Determinations of the Form Factors and
The absolute branching fractions for the decays and
are determined using singly
tagged sample from the data collected around 3.773 GeV with the
BES-II detector at the BEPC. In the system recoiling against the singly tagged
meson, events for and events for decays are observed. Those yield
the absolute branching fractions to be and . The
vector form factors are determined to be
and . The ratio of the two form
factors is measured to be .Comment: 6 pages, 5 figure
Measurements of J/psi Decays into 2(pi+pi-)eta and 3(pi+pi-)eta
Based on a sample of 5.8X 10^7 J/psi events taken with the BESII detector,
the branching fractions of J/psi--> 2(pi+pi-)eta and J/psi-->3(pi+pi-)eta are
measured for the first time to be (2.26+-0.08+-0.27)X10^{-3} and
(7.24+-0.96+-1.11)X10^{-4}, respectively.Comment: 11 pages, 6 figure
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