Heat and Mass Transfer in a Thin Liquid Film over an Unsteady Stretching Surface in the Presence of Thermosolutal Capillarity and Variable Magnetic Field

The heat and mass transfer characteristics of a liquid film which contain thermosolutal capillarity and a variable magnetic field over an unsteady stretching sheet have been investigated. The governing equations for momentum, energy, and concentration are established and transformed to a set of coupled ordinary equations with the aid of similarity transformation. The analytical solutions are obtained using the double-parameter transformation perturbation expansion method. The effects of various relevant parameters such as unsteady parameter, Prandtl number, Schmidt number, thermocapillary number, and solutal capillary number on the velocity, temperature, and concentration fields are discussed and presented graphically. Results show that increasing values of thermocapillary number and solutal capillary number both lead to a decrease in the temperature and concentration fields. Furthermore, the influences of thermocapillary number on various fields are more remarkable in comparison to the solutal capillary number

Cross-Scale Cost Aggregation for Stereo Matching

Human beings process stereoscopic correspondence across multiple scales. However, this bio-inspiration is ignored by state-of-the-art cost aggregation methods for dense stereo correspondence. In this paper, a generic cross-scale cost aggregation framework is proposed to allow multi-scale interaction in cost aggregation. We firstly reformulate cost aggregation from a unified optimization perspective and show that different cost aggregation methods essentially differ in the choices of similarity kernels. Then, an inter-scale regularizer is introduced into optimization and solving this new optimization problem leads to the proposed framework. Since the regularization term is independent of the similarity kernel, various cost aggregation methods can be integrated into the proposed general framework. We show that the cross-scale framework is important as it effectively and efficiently expands state-of-the-art cost aggregation methods and leads to significant improvements, when evaluated on Middlebury, KITTI and New Tsukuba datasets.Comment: To Appear in 2013 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). 2014 (poster, 29.88%

Angular Reconstruction of a Lead Scintillating-Fiber Sandwiched Electromagnetic Calorimeter

A new method called Neighbor Cell Deposited Energy Ratio (NCDER) is proposed to reconstruct incidence position in a single layer for a 3-dimensional imaging electromagnetic calorimeter (ECAL).This method was applied to reconstruct the ECAL test beam data for the Alpha Magnetic Spectrometer-02 (AMS-02). The results show that this method can achieve an angular resolution of 7.36\pm 0.08 / \sqrt(E) \oplus 0.28 \pm 0.02 degree in the determination of the photons direction, which is much more precise than that obtained with the commonly-adopted Center of Gravity(COG) method (8.4 \pm 0.1 /sqrt(E) \oplus 0.8\pm0.3 degree). Furthermore, since it uses only the properties of electromagnetic showers, this new method could also be used for other type of fine grain sampling calorimeters.Comment: 6 pages, 8 figure

Timing Is Critical for an Effective Anti-Metastatic Immunotherapy: The Decisive Role of IFNγ/STAT1-Mediated Activation of Autophagy

BACKGROUND: Immunotherapy is often recommended as an adjuvant treatment to reduce the chance of cancer recurrence or metastasis. Interestingly, timing is very important for a successful immunotherapy against metastasis, although the precise mechanism is still unknown. METHODS AND FINDINGS: Using a mouse model of melanoma metastasis induced by intravenous injection of B16-F10 cells, we investigated the mechanism responsible for the diverse efficacy of the prophylactic or therapeutic TLR4 and TLR9 agonist complex against metastasis. We found that the activation of TLR4 and TLR9 prevented, but did not reverse, metastasis because the potency of this combination was neither sufficient to overcome the tumor cell-educated immune tolerance nor to induce efficacious autophagy in tumor cells. The prophylactic application of the complex promoted antimetastatic immunity, leading to the autophagy-associated death of melanoma cells via IFNγ/STAT1 activation and attenuated tumor metastasis. IFNγ neutralization reversed the prophylactic benefit induced by the complex by suppressing STAT1 activation and attenuating autophagy in mice. However, the therapeutic application of the complex did not suppress metastasis because the complex could not reverse tumor cell-induced STAT3 activation and neither activate IFNγ/STAT1 signaling and autophagy. Suppressing STAT3 activation with the JAK/STAT antagonist AG490 restored the antimetastatic effect of the TLR4/9 agonist complex. Activation of autophagy after tumor inoculation by using rapamycin, with or without the TLR4/9 agonist complex, could suppress metastasis. CONCLUSION AND SIGNIFICANCE: Our studies suggest that activation of IFNγ/STAT1 signaling and induction of autophagy are critical for an efficacious anti-metastatic immunotherapy and that autophagy activators may overcome the timing barrier for immunotherapy against metastasis

Genomic Inference of the Metabolism and Evolution of the Archaeal Phylum Aigarchaeota

Microbes of the phylum Aigarchaeota are widely distributed in geothermal environments, but their physiological and ecological roles are poorly understood. Here we analyze six Aigarchaeota metagenomic bins from two circumneutral hot springs in Tengchong, China, to reveal that they are either strict or facultative anaerobes, and most are chemolithotrophs that can perform sulfide oxidation. Applying comparative genomics to the Thaumarchaeota and Aigarchaeota, we find that they both originated from thermal habitats, sharing 1154 genes with their common ancestor. Horizontal gene transfer played a crucial role in shaping genetic diversity of Aigarchaeota and led to functional partitioning and ecological divergence among sympatric microbes, as several key functional innovations were endowed by Bacteria, including dissimilatory sulfite reduction and possibly carbon monoxide oxidation. Our study expands our knowledge of the possible ecological roles of the Aigarchaeota and clarifies their evolutionary relationship to their sister lineage Thaumarchaeota