997 research outputs found
Dynamical topology and statistical properties of spatiotemporal chaos
For spatiotemporal chaos described by partial differential equations, there
are generally locations where the dynamical variable achieves its local
extremum or where the time partial derivative of the variable vanishes
instantaneously. To a large extent, the location and movement of these
topologically special points determine the qualitative structure of the
disordered states. We analyze numerically statistical properties of the
topologically special points in one-dimensional spatiotemporal chaos. The
probability distribution functions for the number of point, the lifespan, and
the distance covered during their lifetime are obtained from numerical
simulations. Mathematically, we establish a probabilistic model to describe the
dynamics of these topologically special points. In despite of the different
definitions in different spatiotemporal chaos, the dynamics of these special
points can be described in a uniform approach.Comment: 6 pages, 5 figure
Electron-phonon coupling and superconductivity in LiBC
By means of the first-principles density-functional theory calculation and
Wannier interpolation, electron-phonon coupling and superconductivity are
systematically explored for boron-doped LiBC (i.e. LiBC), with
between 0.1 and 0.9. Hole doping introduced by boron atoms is treated
through virtual-crystal approximation. For the investigated doping
concentrations, our calculations show the optimal doping concentration
corresponds to 0.8. By solving the anisotropic Eliashberg equations, we find
that LiBC is a two-gap superconductor, whose superconducting
transition temperature, T, may exceed the experimentally observed value of
MgB. Similar to MgB, the two-dimensional bond-stretching
phonon modes along - line have the largest contribution to
electron-phonon coupling. More importantly, we find that the first two acoustic
phonon modes and around the midpoint of - line play a
vital role for the rise of T in LiBC. The origin of strong
couplings in and modes can be attributed to enhanced
electron-phonon coupling matrix elements and softened phonons. It is revealed
that all these phonon modes couple strongly with -bonding electronic
states.Comment: 7 pages, 10 figures, accepted for publication in EP
On meromorphic functions that share three values of finite weights
AbstractA uniqueness theorem for two distinct non-constant meromorphic functions that share three values of finite weights is proved, which generalizes two previous results by H.X. Yi, and X.M. Li and H.X. Yi. As applications of it, many known results by H.X. Yi and P. Li, etc. could be improved. Furthermore, with the concept of finite-weight sharing, extensions on Osgood–Yang's conjecture and Mues' conjecture, and a generalization of some prevenient results by M. Ozawa and H. Ueda, ect. could be obtained
NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile Virus NS2B-NS3 protease
BACKGROUND The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development. In all crystal structures of the proteases to date, the NS2B cofactor is located far from the substrate binding site (open conformation) in the absence of inhibitor and lining the substrate binding site (closed conformation) in the presence of an inhibitor. METHODS In this work, nuclear magnetic resonance (NMR) spectroscopy of isotope and spin-labeled samples of the West Nile virus protease was used to investigate the occurrence of equilibria between open and closed conformations in solution. FINDINGS In solution, the closed form of the West Nile virus protease is the predominant conformation irrespective of the presence or absence of inhibitors. Nonetheless, dissociation of the C-terminal part of the NS2B cofactor from the NS3 protease (open conformation) occurs in both the presence and the absence of inhibitors. Low-molecular-weight inhibitors can shift the conformational exchange equilibria so that over 90% of the West Nile virus protease molecules assume the closed conformation. The West Nile virus protease differs from the dengue virus protease, where the open conformation is the predominant form in the absence of inhibitors. CONCLUSION Partial dissociation of NS2B from NS3 has implications for the way in which the NS3 protease can be positioned with respect to the host cell membrane when NS2B is membrane associated via N- and C-terminal segments present in the polyprotein. In the case of the West Nile virus protease, discovery of low-molecular-weight inhibitors that act by breaking the association of the NS2B cofactor with the NS3 protease is impeded by the natural affinity of the cofactor to the NS3 protease. The same strategy can be more successful in the case of the dengue virus NS2B-NS3 protease.The project was funded by the Australian Research Council (http://www.arc.gov.au), grant DP0877540
RHINO: Regularizing the Hash-based Implicit Neural Representation
The use of Implicit Neural Representation (INR) through a hash-table has
demonstrated impressive effectiveness and efficiency in characterizing
intricate signals. However, current state-of-the-art methods exhibit
insufficient regularization, often yielding unreliable and noisy results during
interpolations. We find that this issue stems from broken gradient flow between
input coordinates and indexed hash-keys, where the chain rule attempts to model
discrete hash-keys, rather than the continuous coordinates. To tackle this
concern, we introduce RHINO, in which a continuous analytical function is
incorporated to facilitate regularization by connecting the input coordinate
and the network additionally without modifying the architecture of current
hash-based INRs. This connection ensures a seamless backpropagation of
gradients from the network's output back to the input coordinates, thereby
enhancing regularization. Our experimental results not only showcase the
broadened regularization capability across different hash-based INRs like DINER
and Instant NGP, but also across a variety of tasks such as image fitting,
representation of signed distance functions, and optimization of 5D static / 6D
dynamic neural radiance fields. Notably, RHINO outperforms current
state-of-the-art techniques in both quality and speed, affirming its
superiority.Comment: 17 pages, 11 figure
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