128 research outputs found
Anomaly Discovery and Arbitrage Trading
Our model of anomaly discovery has implications for both asset prices and arbitrageurs\u27 trading. Consistent with existing evidence, the discovery of an anomaly reduces its magnitude. Our evidence based on 99 anomalies is consistent with new predictions that the discovery of an anomaly reduces the correlation between the returns its deciles 1 and 10, leading to diversification benefits for passive investors. These effects become linked to the aggregate trading of hedge funds only after discovery. Hedge funds increase (reverse) their positions in exploiting anomalies when their aggregate wealth increases (decreases), further suggesting that these discovery effects operate through arbitrage trading
Convert widespread paraelectric perovskite to ferroelectrics
While nature provides a plethora of perovskite materials, only a few exhibits
large ferroelectricity and possibly multiferroicity. The majority of perovskite
materials have the non-polar CaTiO(CTO)structure, limiting the scope of
their applications. Based on effective Hamiltonian model as well as
first-principles calculations, we propose a general thin-film design method to
stabilize the functional BiFeO(BFO)-type structure, which is a common
metastable structure in widespread CaTiO-type perovskite oxides. It is
found that the improper antiferroelectricity in CTO-type perovskite and
ferroelectricity in BFO-type perovskite have distinct dependences on mechanical
and electric boundary conditions, both of which involve oxygen octahedral
rotation and tilt. The above difference can be used to stabilize the highly
polar BFO-type structure in many CTO-type perovskite materials
Multi-wavelength observations of 2HWC J1928+177: dark accelerator or new TeV gamma-ray binary?
2HWC J1928+177 is a Galactic TeV gamma-ray source detected by the High
Altitude Water Cherenkov (HAWC) Observatory up to ~ 56 TeV. The HAWC source,
later confirmed by H.E.S.S., still remains unidentified as a dark accelerator
since there is no apparent supernova remnant or pulsar wind nebula detected in
the lower energy bands. The radio pulsar PSR J1928+1746, coinciding with the
HAWC source position, has no X-ray counterpart. Our SED modeling shows that
inverse Compton scattering in the putative pulsar wind nebula can account for
the TeV emission only if the unseen nebula is extended beyond r ~ 4 [arcmin].
Alternatively, TeV gamma rays may be produced by hadronic interactions between
relativistic protons from an undetected supernova remnant associated with the
radio pulsar and a nearby molecular cloud G52.9+0.1. NuSTAR and Chandra
observations detected a variable X-ray point source within the HAWC error
circle, potentially associated with a bright IR source. The X-ray spectra can
be fitted with an absorbed power-law model with cm and and exhibit
long-term X-ray flux variability over the last decade. If the X-ray source,
possibly associated with the IR source (likely an O star), is the counterpart
of the HAWC source, it may be a new TeV gamma-ray binary powered by collisions
between the pulsar wind and stellar wind. Follow-up X-ray observations are
warranted to search for diffuse X-ray emission and determine the nature of the
HAWC source.Comment: accepted to ApJ, 8 pages, 7 figure
Sucrose non-fermenting1-related protein kinase VcSnRK2.3 promotes anthocyanin biosynthesis in association with VcMYB1 in blueberry
Sucrose non-fermenting1-related protein kinase-2 (SnRK2) is a plant-specific protein kinase family and an important component of the abscisic acid (ABA) signaling pathway. However, there is a lack of relevant studies in blueberry (Vaccinium corymbosum). In this study, we identified six SnRK2 family members (from VcSnRK2.1 to VcSnRK2.6) in blueberries for the first time. In addition, we found that VcSnRK2.3 expression was not only positively correlated with fruit ripening but was also induced by ABA signaling. Transient expression in blueberry fruits also proved that VcSnRK2.3 promoted anthocyanin accumulation and the expression of anthocyanin synthesis-related genes such as VcF3H, VcDFR, VcANS, and VcUFGT. Transgenic Arabidopsis thaliana seeds and seedlings overexpressing VcSnRK2.3 showed anthocyanin pigmentation. Yeast two-hybrid assays (Y2H) and Bimolecular fluorescence complementation assays (BiFC) demonstrated that VcSnRK2.3 could interact with the anthocyanin positive regulator VcMYB1. Finally, VcSnRK2.3 was able to enhance the binding of VcMYB1 to the VcDFR promoter. Via regulation transcription of anthocyanin biosynthesis genes, VcSnRK2.3 promoted anthocyanin accumulation in blueberry. The above results suggest that VcSnRK2.3 plays an important role in blueberry anthocyanin synthesis, is induced by ABA, and can interact with VcMYB1 to promote anthocyanin biosynthesis in blueberry
HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation
SummaryAcute myeloid leukemia (AML) is driven and sustained by leukemia stem cells (LSCs) with unlimited self-renewal capacity and resistance to chemotherapy. Mutation in the TP53 tumor suppressor is relatively rare in de novo AML; however, p53 can be regulated through post-translational mechanisms. Here, we show that p53 activity is inhibited in inv(16)+ AML LSCs via interactions with the CBFβ-SMMHC (CM) fusion protein and histone deacetylase 8 (HDAC8). HDAC8 aberrantly deacetylates p53 and promotes LSC transformation and maintenance. HDAC8 deficiency or inhibition using HDAC8-selective inhibitors (HDAC8i) effectively restores p53 acetylation and activity. Importantly, HDAC8 inhibition induces apoptosis in inv(16)+ AML CD34+ cells, while sparing the normal hematopoietic stem cells. Furthermore, in vivo HDAC8i administration profoundly diminishes AML propagation and abrogates leukemia-initiating capacity of both murine and patient-derived LSCs. This study elucidates an HDAC8-mediated p53-inactivating mechanism promoting LSC activity and highlights HDAC8 inhibition as a promising approach to selectively target inv(16)+ LSCs
Finding multiple target optimal intervention in disease-related molecular network
Drugs against multiple targets may overcome the many limitations of single targets and achieve a more effective and safer control of the disease. Numerous high-throughput experiments have been performed in this emerging field. However, systematic identification of multiple drug targets and their best intervention requires knowledge of the underlying disease network and calls for innovative computational methods that exploit the network structure and dynamics. Here, we develop a robust computational algorithm for finding multiple target optimal intervention (MTOI) solutions in a disease network. MTOI identifies potential drug targets and suggests optimal combinations of the target intervention that best restore the network to a normal state, which can be customer designed. We applied MTOI to an inflammation-related network. The well-known side effects of the traditional non-steriodal anti-inflammatory drugs and the recently recalled Vioxx were correctly accounted for in our network model. A number of promising MTOI solutions were found to be both effective and safer
Investigating the Short-Term Effects of Cold Stress on Metabolite Responses and Metabolic Pathways in Inner-Mongolia Sanhe Cattle
Inner-Mongolia Sanhe cattle are well-adapted to low-temperature conditions, but the metabolic mechanisms underlying their climatic resilience are still unknown. Based on the 1H Nuclear Magnetic Resonance platform, 41 metabolites were identified and quantified in the serum of 10 heifers under thermal neutrality (5 °C), and subsequent exposure to hyper-cold temperature (−32 °C) for 3 h. Subsequently, 28 metabolites were pre-filtrated, and they provided better performance in multivariate analysis than that of using 41 metabolites. This indicated the need for pre-filtering of the metabolome data in a paired experimental design. In response to the cold exposure challenge, 19 metabolites associated with cold stress response were identified, mainly enriched in “aminoacyl-tRNA biosynthesis” and “valine, leucine, and isoleucine degradation”. A further integration of metabolome and gene expression highlighted the functional roles of the DLD(dihydrolipoamide dehydrogenase), WARS (tryptophanyl-tRNA synthetase), and RARS(arginyl-tRNA synthetase) genes in metabolic pathways of valine and leucine. Furthermore, the essential regulations of SLC30A6 (solute carrier family 30 (zinc transporter), member 6) in metabolic transportation for propionate, acetate, valine, and leucine under severe cold exposure were observed. Our findings presented a comprehensive characterization of the serum metabolome of Inner-Mongolia Sanhe cattle, and contributed to a better understanding of the crucial roles of regulations in metabolites and metabolic pathways during cold stress events in cattle
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