55 research outputs found

    The Impact of Social Culture Environment for Modern Science Development: Based on the Understanding of Merton's Dissertation

    Get PDF
    In the ages of Big Science and under the situation of advocating an innovative society, it’s very significant to re-read the Merton’s Dissertation named ″Science, Technology and Society in the 17th Century England″ and explore fascination of thought and modern value in the classics which was recognized as a work of sociology of science. Along the thinking logic of Merton’s text, we make the history of reduction and in-depth analysis of the England social culture environment in 17th century from three aspects of politics, economy and culture. And with this a base point, some important influences of Social Culture Environment to the rise and development of Modern Science are fully discussed from three perspectives which are the driving force of modern science, the turn of scientific research fields and its interaction mechanism

    BaFe12O19 single-particle-chain nanofibers : preparation, characterization, formation principle, and magnetization reversal mechanism

    Get PDF
    BaFe12O19 single-particle-chain nanofibers have been successfully prepared by an electrospinning method and calcination process, and their morphology, chemistry, and crystal structure have been characterized at the nanoscale. It is found that individual BaFe12O19 nanofibers consist of single nanoparticles which are found to stack along the nanofiber axis. The chemical analysis shows that the atomic ratio of Ba/Fe is 1:12, suggesting a BaFe12O19 composition. The crystal structure of the BaFe12O19 single-particle-chain nanofibers is proved to be M-type hexagonal. The single crystallites on each BaFe12O19 single-particlechain nanofibers have random orientations. A formation mechanism is proposed based on thermogravimetry/differential thermal analysis (TG-DTA), X-ray diffraction (XRD), and transmission electron microscopy (TEM) at six temperatures, 250, 400, 500, 600, 650, and 800 �C. The magnetic measurement of the BaFe12O19 single-particle-chain nanofibers reveals that the coercivity reaches a maximum of 5943 Oe and the saturated magnetization is 71.5 emu/g at room temperature. Theoretical analysis at the micromagnetism level is adapted to describe the magnetic behavior of the BaFe12O19 single-particle-chain nanofibers

    An immune-related prognostic model predicts neoplasm-immunity interactions for metastatic nasopharyngeal carcinoma

    Get PDF
    BackgroundThe prognosis of nasopharyngeal carcinoma (NPC) has been recognized to improve immensely owing to radiotherapy combined with chemotherapy. However, patients with metastatic NPC have a poor prognosis. Immunotherapy has dramatically prolonged the survival of patients with NPC. Hence, further research on immune-related biomarkers is imperative to establish the prognosis of metastatic NPC.Methods10 NPC RNA expression profiles were generated from patients with or without distant metastasis after chemoradiotherapy from the Fujian Cancer Hospital. The differential immune-related genes were identified and validated by immunohistochemistry analysis. The method of least absolute shrinkage and selection operator (LASSO)was used to further establish the immune-related prognostic model in an external GEO database (GSE102349, n=88). The immune microenvironment and signal pathways were evaluated in multiple dimensions at the transcriptome and single-cell levels.Results1328 differential genes were identified, out of which 520 were upregulated and 808 were downregulated. Notably, most of the immune genes and pathways were down-regulated in the metastasis group. A prognostic immune model involving nine hub genes. Patients in low-risk group were characterized by survival advantage, hot immune phenotype and benefit from immunotherapy. Compared with immune cells, malignant cell exhibited the most active levels of risk score by ssGSEA. Accordingly, intercellular communications including LT, CD70, CD40 and SPP1, and the like, between high-risk and low-risk were explored by the R package “Cellchat”.ConclusionWe have constructed a model based on immunity of metastatic NPC and determined its prognostic value. The model identified the level of immune cell infiltration, cell-cell communication, along with potential immunotherapy for metastatic NPC

    Research on the relationship between energy dissipation and stress drop in uniaxial compression failure of coal samples

    No full text
    Compared with the energy dissipation of coal and rock failure, the more intuitive stress drop has certain practical significance for assisting the study of coal and rock failure characteristics and variation law of geophysical signals. And the stress drop is the macroscopic manifestation of energy dissipation. Most of the current research on energy dissipation and stress drop is only for one-sided research, without a comprehensive study on the relationship between the two. The relationship between the two is not clear, which restricts the application of the stress drop index. In order to solve the above problems, YAW−600 microcomputer controlled electro-hydraulic servo pressure testing machine is used to carry out uniaxial compression experiments on coal samples. The evolution characteristics of energy dissipation index and stress drop index in the whole process of coal sample failure under load and the relationship between them are studied and analyzed. Based on theoretical analysis, the relationship between energy dissipation index and the product of stress level and stress drop index is further studied. The results show that the energy dissipation index and stress drop index in the uniaxial compression failure process of coal sample have good response to the significant fracture of coal sample. And the indexes are in the same order of magnitude in numerical value, but they are not completely proportional. The energy dissipation rate is linearly related to the product of stress level and stress drop rate. And the energy dissipation is linearly related to the product of stress level and stress drop. The goodness of fit is 1 and 0.997 5 respectively. Compared with the energy dissipation index, the more intuitive product of stress level and stress drop index is more sensitive to the significant damage of coal samples, and has a burst characteristic. The research results clarify the relationship between energy dissipation and stress drop, and provide a certain theoretical support for the application of stress drop index. The relationship can be used for in-depth research on the coal rock failure characteristics and the variation law of geophysical signals such as acoustic emission, electromagnetic radiation and infrared radiation

    Numerical calculation and experimental analysis of thermal environment in industrialized aquaculture facilities.

    No full text
    With the increasing market demand for high-quality aquatic products, the application of industrialized aquaculture facilities may get more attention. In order to improve the poor performance of thermal insulation, the accuracy of the numerical model was verified in this study through actual measured data. The model verification results shown that the average relative errors of the measured and calculated values of indoor air temperature, water temperature and roof inner surface temperature in the industrialized aquaculture workshop is within 2.5%, it suggested that the numerical calculation results are accurate. Furthermore, the thermal environment and thermal insulation performance of industrialized aquaculture facilities in winter were conducted based on the numerical calculations. After optimized the thermophysical parameters of the workshop enclosure structure, we found that the water body temperature could reach 21°C (which was close to the breeding temperature of grouper (Epinephelinae). Therefore, the numerical calculation method was further used to analyze the energy consumption of aquaculture water in January of a typical year in this area by heating to three constant temperatures (22, 25, and 28°C). When the aquaculture water was heated to the three constant temperature states, it needed to consume 8.56×105, 1.02×106 and 1.22×106 MJ of energy respectively, which were equal to the amount of energy released by the complete combustion of 29.3, 35.1 and 41.8 t standard coal. Moreover, it is concluded that the artificial temperature increase in winter maintains the temperature in the range of 22~25°C to provide the highest heating efficiency. This conclusion can provide theoretical basis and application reference for industrialized aquaculture in winter

    Detection ability analysis of ground based imaging polarization detector

    No full text
    A ground based imaging polarization detector for astronomical observation is designed, the working principle is analyzed and the mathematical models of degree of polarization and detection ability of the detector are derived. The SNR (signal-to-noise ratio) and number of phoelectrons needed by the detector are analyzed by simulation with the detection demand of 1% or 2% degree of polarization. Then, the integration time of the detector is calculated when detecting stars with different brightness according to the parameters of the detector we designed. The theoretical basis is given through these results. (C) 2015 Elsevier GmbH. All rights reserved
    corecore