4,097 research outputs found

    Salmonella prosthetic joint septic arthritis

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72297/1/j.1469-0691.2002.00466.x.pd

    Momentum-Dependent Mean Field Based Upon the Dirac-Brueckner Approach for Nuclear Matter

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    A momentum-dependent mean field potential, suitable for application in the transport-model description of nucleus-nucleus collisions, is derived in a microscopic way. The derivation is based upon the Bonn meson-exchange model for the nucleon-nucleon interaction and the Dirac-Brueckner approach for nuclear matter. The properties of the microscopic mean field are examined and compared with phenomenological parametrizations which are commonly used in transport-model calculations.Comment: 15 pages text (RevTex) and 4 figures (postscript in a separate uuencoded file), UI-NTH-930

    Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory

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    A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes important for long-lasting forms of synaptic plasticity and memory storage. In the forebrain, the anchoring protein gravin recruits a signaling complex containing PKA, PKC, calmodulin, and PDE4D (phosphodiesterase 4D) to the β2-adrenergic receptor. Here, we show that mice lacking the α-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasticity including β2-adrenergic receptor-mediated plasticity, and selective impairments of long-term memory storage. Furthermore, both hippocampal β2-adrenergic receptor phosphorylation by PKA, and learning-induced activation of ERK in the CA1 region of the hippocampus are attenuated in mice lacking gravin-α. We conclude that gravin compartmentalizes a significant pool of PKA that regulates learning-induced β2-adrenergic receptor signaling and ERK activation in the hippocampus in vivo, thereby organizing molecular interactions between glutamatergic and noradrenergic signaling pathways for long-lasting synaptic plasticity, and memory storage

    Can woodland caribou and the forest industry coexist: The Ontario scene

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    Ontario is in the process of developing a strategy to improve the likelihood of woodland caribou (Rangifer tarandus caribou) and the forest industry coexisting in the province. This strategy is described within a set of proposed Timber Management Guidelines for the Provision of Woodland Caribou Habitat. The proposed guidelines advocate managing for large blocks of suitable winter habitat across caribou range, large cutovers to regenerate caribou winter habitat and the protection of traditional calving areas and travel routes. Summer habitat will be provided by the resulting mosaic. The forest industry can provide a sustainable supply of woodland caribou habitat that was traditionally maintained by wildfire

    Teacher resilience in adverse contexts: issues of professionalism and professional identity

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    Teacher resilience is a construct that is relative, developmental and dynamic; it is socially constructed and depends on personal and professional dispositions. Issues of commitment, professionalism, and professional identity, for instance, need to be taken into account if teacher resilience is to be fully understood. In this chapter I draw upon a larger piece of research aimed at investigating teachers’ work and lives in challenging circumstances. Data were collected through a national survey (n=2702 teachers), focus group (n=99 teachers) and interviews to 11 school principals. Findings suggest the connection between teacher commitment and resilience which are associated with issues of school culture and leadership, a sense of vocation, and teachers’ beliefs and professional values. Factors and sources of teacher motivation and resilience are also identified within a context marked by teacher intensification, lack of trust, worsening of teaching conditions, lower social and economic status and legislative “tsunami”. The chapter ends with the discussion of the importance of relationships in the teaching profession and issues of motivation and professionalism which entails given ways of being and feeling as a teacher.Financial Support by CIEC (Research Centre on Child Studies, IE, UMinho; FCT R&D unit 317, Portugal) by the Strategic Project UID/CED/00317/2013, with financial support of National Funds through the FCT (Foundation for Science and Technology) and co-financed by European Regional Development Funds (FEDER) through the COMPETE 2020 - Competitiveness and Internationalization Operational Program (POCI) with the reference POCI-01-0145-FEDER-00756

    Quantum Monte Carlo calculations of the one-body density matrix and excitation energies of silicon

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    Quantum Monte Carlo (QMC) techniques are used to calculate the one-body density matrix and excitation energies for the valence electrons of bulk silicon. The one-body density matrix and energies are obtained from a Slater-Jastrow wave function with a determinant of local density approximation (LDA) orbitals. The QMC density matrix evaluated in a basis of LDA orbitals is strongly diagonally dominant. The natural orbitals obtained by diagonalizing the QMC density matrix resemble the LDA orbitals very closely. Replacing the determinant of LDA orbitals in the wave function by a determinant of natural orbitals makes no significant difference to the quality of the wave function's nodal surface, leaving the diffusion Monte Carlo energy unchanged. The Extended Koopmans' Theorem for correlated wave functions is used to calculate excitation energies for silicon, which are in reasonable agreement with the available experimental data. A diagonal approximation to the theorem, evaluated in the basis of LDA orbitals, works quite well for both the quasihole and quasielectron states. We have found that this approximation has an advantageous scaling with system size, allowing more efficient studies of larger systems.Comment: 13 pages, 4 figures. To appear in Phys. Rev.

    Understanding and examining teacher resilience from multiple perspectives

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    In this chapter, I argue that differing conceptualisations of the construct of resilience shape and enrich the research questions and methodology used to examine it. In addition, the conceptual focus has implications for questions such as whose responsibility it is for the development of resilience. Research conducted within two Australian projects, Keeping Cool and BRiTE (Building Resilience in Teacher Education) is used as an illustration of the impact of a changing conceptual focus. For example, beginning with a psychological perspective led to an examination of risk and protective factors for individuals. More contextual approaches involved a comparison of countries. Recent systemic views support a model that encompasses both personal and contextual characteristics, as well as strategies used and outcomes achieved. It is argued that taking multiple perspectives in this programme of work has enabled the incorporation of a broad range of research methods and findings, and contributed to a deeper understanding of the construct of teacher resilience

    Influence of Arctic sea ice on European summer precipitation

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    Copyright © 2013 IOP Publishing Ltd. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (http://creativecommons.org/licenses/by/3.0/). Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.Open Access journalThe six summers from 2007 to 2012 were all wetter than average over northern Europe. Although none of these individual events are unprecedented in historical records, the sequence of six consecutive wet summers is extraordinary. Composite analysis reveals that observed wet summer months in northern Europe tend to occur when the jet stream is displaced to the south of its climatological position, whereas dry summer months tend to occur when the jet stream is located further north. Highly similar mechanisms are shown to drive simulated precipitation anomalies in an atmospheric model. The model is used to explore the influence of Arctic sea ice on European summer climate, by prescribing different sea ice conditions, but holding other forcings constant. In the simulations, Arctic sea ice loss induces a southward shift of the summer jet stream over Europe and increased northern European precipitation. The simulated precipitation response is relatively small compared to year-to-year variability, but is statistically significant and closely resembles the spatial pattern of precipitation anomalies in recent summers. The results suggest a causal link between observed sea ice anomalies, large-scale atmospheric circulation and increased summer rainfall over northern Europe. Thus, diminished Arctic sea ice may have been a contributing driver of recent wet summers.UK Natural Environment Research Council (NERC
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