6 research outputs found

    PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

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    Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1 is highly expressed by fibroblasts from patients with systemic sclerosis and promotes TGFβ activity via SRC–ERK–SMAD3 signaling

    STAT3, stem cells, cancer stem cells and p63

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