Synthesis of a new class of bis heterocycles

1295-1300A variety of bis heterocycles-oxazolyl / thiazolyl / imidazolyl pyrroles and pyrazoles have been prepared adopting 1,3-dipolar cycloaddition of tosylmethyl isocyanide and diazomethane to oxazolyl / thiazolyl / imidazolyl acrylamides

Synthesis and cytotoxic activity of sulfur linked mono / bis heterocycles

1173-1178A variety of sulfur linked mono / bis heterocycles have been prepared and their cytotoxic activity on A549 lung adenocarcinoma cells studied. The imidazolyl and benzimidazolyl thiadiazoles (7c, 8c) display appreciable cytotoxic activity against A549 cells

Synthesis, Antioxidant, and Cytotoxic Activities of N-Azole Substituted Thiomorpholine Derivatives

A new class of N-azole substituted thiomorpholine derivatives were prepared and their antioxidant and cytotoxic activities were studied. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited radical scavenging activity greater than the standard ascorbic acid. On the other hand, the thiazolyl thiomorpholine 10c having a chloro substituent on the aromatic ring was identified as a remarkable lead molecule for cytotoxic activity against A549 and HeLa cells, with IC50 values of 10.1 and 30.0 mu M, respectively

Synthesis, antioxidant, and cytotoxic activities of bis(oxazolyl/thiazolyl/imidazolyl)amidomethanesulfonyl Acetamides

A new class of bis(oxazolyl/thiazolyl/imidazolyl)amidomethanesulfonyl acetamides was prepared from the respective (oxazolyl/thiazolyl/imidazolyl)carbamoyl-methylthio acetic acid and studied their antioxidant activity and cytotoxic activitity against A549 lung adenocarcinoma cells. The methyl-substituted sulfonyl bisoxazoles exhibited excellent radical scavenging activity. On the other hand, the chloro-substituted sulfonyl bisthiazoles (IC50 = 49 A mu M) and sulfonyl bisimidazoles (IC50 = 24 A mu M) showed noticeable cytotoxic activity on A549 cells