Pengaruh Iklim Organisasi Terhadap Eustress Dan Kepuasan Kerja Karyawan (Studi Pada Karyawan Perum Jasa Tirta I Malang Jawa Timur)

The purpose of this study is to determine the influence of organizational climate to eustress and employee job satisfaction. If organizational climate beneficial to the individual needs, it can be assured level of behavior towards a more positive and finally employee job satisfaction can be achieved. Path analysis is used with obtained data by using a structured questionnaire. The number of respondents 70 employees Perum Jasa Tirta I Malang. The results showed that organizational climate has a significant influence on eustress. Eustress insignificantly influence employee job satisfaction. Organizational climate has a direct effect and indirect effect on employee job satisfaction through eustress.it is concluded that is getting better the organizational climate it will increase eustress and employee job satisfaction

Pengaruh Corporate Governance Terhadap Profitabilitas (Studi Pada Perusahaan Perbankan Yang Terdaftar Di Bursa Efek Indonesia Periode 2013-2015)

This study aims to know the influence of Corporate Governance toward company profitability. Corporate Governance in this study is proxied by proportion of independent board, audit committee, manajerial ownership and institutional ownership. The company's profitability is measured by using the Return on Equity (ROE) and Return on Asset (ROA). The type of this research is explanatory research with quantitative approach. Population of this research is banking company's who are listed in Indonesia Stock Exchange in 2013-2015. The sample selection technique is using purposive sampling method. Type of data are used secondary. Data analysis technique in this study is using multiple linier regression analysis. The result of this study showed that simultaneously, proportion of independent board, audit committee, manajerial ownership and institutional ownership have a siginificant effect on ROA but does not have significant effect on ROE. Proportion of independent board does not have a significant effect on ROE and ROA. Audit committee does not have a significant effect on ROE and ROA. Manajerial ownership does not have a significant effect on ROE and ROA. Institutional ownership does have a significant effect on ROE and ROA

Ekstrak Keladi Tikus (Typhonium Flagelliforme) Fraksi Diklorometanolik dan Ekspresi Caspase-3 dan P21 Cell-Line Kanker Payudara MCF-7

The dichloromethanolic fraction of keladi tikus (Typhonium flagelliforme) extract and the expression of p21 and caspase-3 of MCF-7 breast cancer cell-lineBackground: Breast cancer has a high degree of heterogeneity and problems in therapy, such as insensitive to antiproliferation signal and able to escape from apoptosis program. Typhonium flagelliforme (Lodd), Blume (Araceae) more commonly known as keladi tikus in Indonesia, often used as alternative in treating cancer, including breast cancer. The objective of study is proving the dichloromethanolic fraction of Typhonium flagelliforme tuber extracts influence on the expression of caspase-3 and p21 of MCF-7 cell-line that have deletion in CASP-3 gene.Methods: This study adapts laboratory experimental in-vitro in cells-line MCF-7, with “post test control group only design” and divided into two groups, were incubated in 5h, 10h and 20h. The control group received no other treatment. The treatment group received the dichloromethanolic fraction of Typhonium flagelliforme tuber extracts in IC50. Starting with cytotoxicity assay using MTT to determine the IC50, followed by Immunocytochemical analysis to observe the expression of p21 and caspase-3.Results: Paired sample T test shows a significant differences in treatment groups compared with the controls (p<0.05), namely an increase in the expression of nuclear p21 and caspase-3 on 20h incubation.Conclusion: There were increased in the expression of caspase-3 and nuclear p21, as well as depleted the cytoplasmic of p21 on MCF-7 cell-line that have deletion in CASP-3 in treatment by tuber extract of Typhonium flagelliforme dichloromethanolic fraction

Peranan Ekosistem Hutan Mangrove pada Imunitas terhadap Malaria: Studi di Kecamatan Labuhan Maringgai Kabupaten Lampung Timur

One of the ecological function of mangrove forests is a habitat for mosquitoes that cause malaria (Anopheles sp.). Epidemic of malaria could increased as a result of mangrove degradation. The damage of mangrove forests stimulate Anopheles sp. migrate to other habitats such as settlements, that become malaria vector. The purpose of this research was to determine the effect of mangrove forest ecosystems both intrinsic and extrinsic factors in immunity to malaria. This research was conducted on June 2014 in the Muara Gading Mas Village, Bandar Negeri, Sriminosari, and Margasari, Sub-district Labuhan Maringgai, District East Lampung. The data were collected through interviews and survey/observations method. The impact of each variable used binary logistic regression models. Parameter optimization used software Minitab 16. The result of research have been demonstrated that there is influence both intrinsic and extrinsic factors in immunity to malaria in mangrove forest. Factors that increase resistance to malaria: (a) gender, male37.42 fold of female, (b) age, getting older every 1 year doubled to 1.17 times of originally, (c) education, the higher it isreduced to 0.001 times the originally, (d) livelihood, besides fisher 0,001 fold of fisherman, (e) the distance settlements to the health facility, each reduced to 1 meter doubled to 0.09 times the originally, (f) the distance home to mangroves, each increase of 1 meter doubled to 1,001 times the originally, (g) the dustbin, there are bins 239.71 better than none, (h) the malaria program, multiply 3,71E+05 originally than none, (i) extensive mangrove, increasing 1 m2 become 1,001 fold of originally, and (j) mangrove density, increasing 1 population/ha multiply 1.18 fold originally

The Effect of Differences Leachate Concentration and Material Properties on Electrical Conductivity of Volcanic Deposits – Case Studies Piyungan Landfill Bantul Yogyakarta

Monitoring at the contaminated subsurface soil, have been conducted by using the geophysical surface method, especially for geoelectrical resistivity method. Monitoring is commonly conducted by using geoelectrical resistivity through measuring the value of Electrical Resistivity (ER) or Electrical Conductivity (EC) of leachate contaminated soil layer. EC measurement value of soil is affected by many factors, among others, particle conduction of soil materials, surface conduction, fluid conduction in the pores as well as the effect of particle shape and soil materials. Piyungan landfill is the main disposal site of Yogyakarta municipal solid waste. This landfill located mainly on the tertiary rocks of volcanic rocks and its weathering products. In order to improve the accuracy of geoelectrical measurements on resistivity in monitoring soil layers from contaminated leachate on this area, this research conducted several measurements on physical properties of soil sample and electrical properties of leachate in the saturated soil samples. The measurement of physical properties includes: porosity, clay content, particle content, and cation exchange capacity (CEC) value. The soil samples were collected from 3 locations around Piyungan Landfill. Type of soils are taken from the alluvial deposits (Sample B), weathered tuffaceous sandstone-claystone (Sample D), and weathered andesitic breccia (Sample F). Samples were made in containers, saturated with aquades-leachate solution with 12 different concentration levels. Electrical conductivity (EC) was measured by using Soil Box Miller and Geoelectric Resistivity Oyo McOhm. According to results of physical properties analysis, the grain size of soils are dominantly sandy clayey silt in grain size distribution, with clay content ranging from 33.0--38.4 %, the CEC values ranging from 26.8--52.7 meq/100 gr, and the porosity of samples B, D and F is 58.85 %, 55.30 %, 59.24 %, respectively. Based on the experiments with 12 different leachate concentrations, there is a linear increase in EC of 0.718mS/cm for every increase in electrical conductivity pore fluid (ECf ) 1 mg/l in samples B, while in samples D and F are 0.492 mS/cm and 0.284 mS/cm respectively. Plotting the data of EC vs ECf for each samples and ER vs ECf , it can be concluded the slope ofDEC/DECf differ for each samples and the electrical conductivity value of different concentration of leachate is very sensitive for alluvial deposits compare to the weathered tuffaceous sandstone-claystone and weathered volcanic breccia deposits

Genetic Polymorphism Analysis of 5' Untranslated Region of Thyroglobulin Gene in Bali Cattle (Bos Javanicus) From Three Different Regions of Indonesia

The g.422C>T nucleotide variations in the 5' untranslated region (5'UTR) of TG gene (called as TG5) has been reported to be associated with level in intramuscular fat (IMF) content or marbling in beef cattle. The objective of this study was to confirm genetic polymorphism of TG5 gene in Bali cattle populations from three different regions as the main resources of Bali cattle in Indonesia. A total of 200 head of Bali cattle have been performed genotyping on TG5 gene using polymerase chain reaction-restriction fragment lenght polymorphism (PCR-RFLP) method and sequence analysis. Results of the study confirmed that TG5 was monomorphic in Bali cattle wherever their origin regions. Moreover, nine candidate SNPs were detected within 5'UTR of TG gene in Bali cattle compared to Genbank reference sequences, although no SNP variations among Bali cattle sample studied. The new other genetic markers within an entire TG gene suggested to be explored and verified for their polymorphisms in Bali cattle. The nine candidate SNPs were also required further verification and validation in a larger sample to be regarded as new SNPs between Bali cattle and Genbank reference sequences

Efficacy of trifocal versus bifocal bone transport on large tibial bone defect: a systematic review and meta-analysis

One of the most common long-term complication of chronic osteomyelitis of tibia is segmental bone loss. One of the methods to manage the segmental bone loss in osteomyelitis is bone transport technique, which is able to reconstruct a defect of more than 6 cm. This paper aims to systematically review and analyze the outcome of bifocal and trifocal bone distraction technique on the tibial bony defect. A comprehensive literature search was performed using PubMed, Google Scholar, and Cochrane library. The inclusion criteria were any studies about comparison between bifocal bone transports with trifocal bone transport in management of large tibial bone defect. The outcomes assessed includes external fixation index, duration of regenerate consolidation, lengthening speed, bone transport distance, and operating time. Two studies reported shorter external fixation index in total of 57 fractures in the trifocal group and 61 fractures in the bifocal group. The meta-analysis showed significant difference in external fixation index between the two groups (Figure 1; RR=-44.37; 95% CI 73.73-15.01; p<0.0001) with significant heterogeneity (Chi square=11.38, p=0.0007); I2: 91%. Although only two studies were compared, both studies had almost similar subjects, and shown that trifocal bone transport technique had faster external fixator index compared to the bifocal bone transport group in the setting of severe bone loss in tibial fracture