The Ursinus Weekly, April 23, 1917

Varsity breaks even in week-end battles • Coming: Dandy Dick • Freshmen royally entertain juniors • Dr. Hoy\u27s address • Zwinglian prize essay: The indifference of youth • Senator Knox commencement orator • Notice to subscribers • Literary societies • On the campushttps://digitalcommons.ursinus.edu/weekly/2590/thumbnail.jp

The Ursinus Weekly, January 14, 1918

Hahnemann easy victim of Ursinus • College students and the war • Ursinus defeats Drexel and Moravian • Reserves defeat Boyertown • Prize oration: The heart of the war god • Christian associations • Literary societies • A fable of two college fopshttps://digitalcommons.ursinus.edu/weekly/2545/thumbnail.jp

The Ursinus Weekly, April 16, 1917

Varsity nine loses close game • Military training officially instituted • Hamilton Holt on Japan to-day • Zwinglian prize essay: The indifference of youth • First aid class • Seminary notes • Christian organizations • Literary societies • On the campus • Our spring birdshttps://digitalcommons.ursinus.edu/weekly/2589/thumbnail.jp

A Transient Receptor Potential Channel Expressed in Taste Receptor Cells

We used differential screening of cDNAs from individual taste receptor cells to identify candidate taste transduction elements in mice. Among the differentially expressed clones, one encoded Trpm5, a member of the mammalian family of transient receptor potential (TRP) channels. We found Trpm5 to be expressed in a restricted manner, with particularly high levels in taste tissue. In taste cells, Trpm5 was coexpressed with taste-signaling molecules such as -gustducin, G13, phospholipase C-2 (PLC-2) and inositol 1,4,5-trisphosphate receptor type III (IP3R3). Our heterologous expression studies of Trpm5 indicate that it functions as a cationic channel that is gated when internal calcium stores are depleted. Trpm5 may be responsible for capacitative calcium entry in taste receptor cells that respond to bitter and/or sweet compounds