5 research outputs found
C(alkenyl)–H Activation via Six-Membered Palladacycles: Catalytic 1,3-Diene Synthesis
A catalytic
method to prepare highly substituted 1,3-dienes from
two different alkenes is described using a directed, palladiumÂ(II)-mediated
CÂ(alkenyl)–H activation strategy. The transformation exhibits
broad scope across three synthetically useful substrate classes masked
with suitable bidentate auxiliaries (4-pentenoic acids, allylic alcohols,
and bishomoallylic amines) and tolerates internal nonconjugated alkenes,
which have traditionally been a challenging class of substrates in
this type of chemistry. Catalytic turnover is enabled by either MnO<sub>2</sub> as the stoichiometric oxidant or co-catalytic CoÂ(OAc)<sub>2</sub> and O<sub>2</sub> (1 atm). Experimental and computational
studies were performed to elucidate the preference for CÂ(alkenyl)–H
activation over other potential pathways. As part of this effort,
a structurally unique alkenylpalladiumÂ(II) dimer was isolated and
characterized
C(alkenyl)–H Activation via Six-Membered Palladacycles: Catalytic 1,3-Diene Synthesis
A catalytic
method to prepare highly substituted 1,3-dienes from
two different alkenes is described using a directed, palladiumÂ(II)-mediated
CÂ(alkenyl)–H activation strategy. The transformation exhibits
broad scope across three synthetically useful substrate classes masked
with suitable bidentate auxiliaries (4-pentenoic acids, allylic alcohols,
and bishomoallylic amines) and tolerates internal nonconjugated alkenes,
which have traditionally been a challenging class of substrates in
this type of chemistry. Catalytic turnover is enabled by either MnO<sub>2</sub> as the stoichiometric oxidant or co-catalytic CoÂ(OAc)<sub>2</sub> and O<sub>2</sub> (1 atm). Experimental and computational
studies were performed to elucidate the preference for CÂ(alkenyl)–H
activation over other potential pathways. As part of this effort,
a structurally unique alkenylpalladiumÂ(II) dimer was isolated and
characterized
C(alkenyl)–H Activation via Six-Membered Palladacycles: Catalytic 1,3-Diene Synthesis
A catalytic
method to prepare highly substituted 1,3-dienes from
two different alkenes is described using a directed, palladiumÂ(II)-mediated
CÂ(alkenyl)–H activation strategy. The transformation exhibits
broad scope across three synthetically useful substrate classes masked
with suitable bidentate auxiliaries (4-pentenoic acids, allylic alcohols,
and bishomoallylic amines) and tolerates internal nonconjugated alkenes,
which have traditionally been a challenging class of substrates in
this type of chemistry. Catalytic turnover is enabled by either MnO<sub>2</sub> as the stoichiometric oxidant or co-catalytic CoÂ(OAc)<sub>2</sub> and O<sub>2</sub> (1 atm). Experimental and computational
studies were performed to elucidate the preference for CÂ(alkenyl)–H
activation over other potential pathways. As part of this effort,
a structurally unique alkenylpalladiumÂ(II) dimer was isolated and
characterized
C(alkenyl)–H Activation via Six-Membered Palladacycles: Catalytic 1,3-Diene Synthesis
A catalytic
method to prepare highly substituted 1,3-dienes from
two different alkenes is described using a directed, palladiumÂ(II)-mediated
CÂ(alkenyl)–H activation strategy. The transformation exhibits
broad scope across three synthetically useful substrate classes masked
with suitable bidentate auxiliaries (4-pentenoic acids, allylic alcohols,
and bishomoallylic amines) and tolerates internal nonconjugated alkenes,
which have traditionally been a challenging class of substrates in
this type of chemistry. Catalytic turnover is enabled by either MnO<sub>2</sub> as the stoichiometric oxidant or co-catalytic CoÂ(OAc)<sub>2</sub> and O<sub>2</sub> (1 atm). Experimental and computational
studies were performed to elucidate the preference for CÂ(alkenyl)–H
activation over other potential pathways. As part of this effort,
a structurally unique alkenylpalladiumÂ(II) dimer was isolated and
characterized
C(alkenyl)–H Activation via Six-Membered Palladacycles: Catalytic 1,3-Diene Synthesis
A catalytic
method to prepare highly substituted 1,3-dienes from
two different alkenes is described using a directed, palladiumÂ(II)-mediated
CÂ(alkenyl)–H activation strategy. The transformation exhibits
broad scope across three synthetically useful substrate classes masked
with suitable bidentate auxiliaries (4-pentenoic acids, allylic alcohols,
and bishomoallylic amines) and tolerates internal nonconjugated alkenes,
which have traditionally been a challenging class of substrates in
this type of chemistry. Catalytic turnover is enabled by either MnO<sub>2</sub> as the stoichiometric oxidant or co-catalytic CoÂ(OAc)<sub>2</sub> and O<sub>2</sub> (1 atm). Experimental and computational
studies were performed to elucidate the preference for CÂ(alkenyl)–H
activation over other potential pathways. As part of this effort,
a structurally unique alkenylpalladiumÂ(II) dimer was isolated and
characterized