112 research outputs found
Deriving Telescope Mueller Matrices Using Daytime Sky Polarization Observations
Telescopes often modify the input polarization of a source so that the
measured circular or linear output state of the optical signal can be
signficantly different from the input. This mixing, or polarization
"cross-talk", is defined by the optical system Mueller matrix. We describe here
an efficient method for recovering the input polarization state of the light
and the full 4 x 4 Mueller matrix of the telescope with an accuracy of a few
percent without external masks or telescope hardware modification. Observations
of the bright, highly polarized daytime sky using the Haleakala 3.7m AEOS
telescope and a coude spectropolarimeter demonstrate the technique.Comment: Accepted for publication in PAS
A comparative study of high-field diamagnetic fluctuations in deoxygenated YBa2Cu3O(7-x) and polycrystalline (Bi-Pb)2Sr2Ca3O(10)
We studied three single crystals of YBa2Cu3O{7-x} with Tc= 62.5, 52, and 41
K, and a textured specimen of (Bi-Pb)2Sr2Ca2Cu3O10 with Tc=108 K, for H//c
axis. The reversible data were interpreted in terms of 2D lowest-Landau-level
fluctuation theory. The data were fit well by the 2D LLL expression for
magnetization obtained by Tesanovic etal., producing reasonable values of kappa
but larger values of dHc2/dT. Universality was studied by obtaining a
simultaneous scaling of Y123 data and Bi2223. An expression for the 2D x-axis
LLL scaling factor used to obtain the simultaneous scaling was extracted from
theory, and compared with the experimental values. The comparison between the
values of the x-axis produced a deviation of 40% which suggests that the
hypothesis of universality of the 2D-LLL fluctuations is not supported by the
studied samples. We finaly observe that Y123 magnetization data for
temperatures above obbey a universal scaling obtained for the diamagnetic
fluctuation magnetization from a theory considering non-local field effects.
The same scaling was not obbeyed by the corresponding magnetization calculated
from the two-dimensional lowest-Landau-level theory.Comment: 7 pages 5 figures, accept in Journ. Low Temp. Phy
Light scattering and trapping in different thin film photovoltaic device
Light trapping in different thin film technologies is investigated in the context of the European integrated project ATHLET since it allows for thinner devices and thus for reduction of costs for absorber material preparation as well as for advanced multi-junction solar cells. In silicon technology, rough interfaces are typically introduced by roughening of substrates, transparent conducting oxides (TCOs) and/or reflectors at the back side to scatter the light into the absorber material. Well known rough TCOs, plasma-textured poly-Si as well as rough Cu(In,Ga)Se2 (CIGS) absorbers are used as source for light scattering in microcrystalline silicon solar cells and compared regarding their surface roughness. The results prove that CIGS and poly silicon solar cells provide efficient light scattering by the surface features of the rough absorber
‘Essential clinical global health’: A multi-national collaboration develops a pioneering new 2015 textbook for global health trainees and clinicians working in resource-limited settings
The Interface Region Imaging Spectrograph (IRIS)
The Interface Region Imaging Spectrograph (IRIS) small explorer spacecraft
provides simultaneous spectra and images of the photosphere, chromosphere,
transition region, and corona with 0.33-0.4 arcsec spatial resolution, 2 s
temporal resolution and 1 km/s velocity resolution over a field-of-view of up
to 175 arcsec x 175 arcsec. IRIS was launched into a Sun-synchronous orbit on
27 June 2013 using a Pegasus-XL rocket and consists of a 19-cm UV telescope
that feeds a slit-based dual-bandpass imaging spectrograph. IRIS obtains
spectra in passbands from 1332-1358, 1389-1407 and 2783-2834 Angstrom including
bright spectral lines formed in the chromosphere (Mg II h 2803 Angstrom and Mg
II k 2796 Angstrom) and transition region (C II 1334/1335 Angstrom and Si IV
1394/1403 Angstrom). Slit-jaw images in four different passbands (C II 1330, Si
IV 1400, Mg II k 2796 and Mg II wing 2830 Angstrom) can be taken simultaneously
with spectral rasters that sample regions up to 130 arcsec x 175 arcsec at a
variety of spatial samplings (from 0.33 arcsec and up). IRIS is sensitive to
emission from plasma at temperatures between 5000 K and 10 MK and will advance
our understanding of the flow of mass and energy through an interface region,
formed by the chromosphere and transition region, between the photosphere and
corona. This highly structured and dynamic region not only acts as the conduit
of all mass and energy feeding into the corona and solar wind, it also requires
an order of magnitude more energy to heat than the corona and solar wind
combined. The IRIS investigation includes a strong numerical modeling component
based on advanced radiative-MHD codes to facilitate interpretation of
observations of this complex region. Approximately eight Gbytes of data (after
compression) are acquired by IRIS each day and made available for unrestricted
use within a few days of the observation.Comment: 53 pages, 15 figure
Clathrin- and Dynamin-Independent Endocytosis of FGFR3 – Implications for Signalling
Endocytosis of tyrosine kinase receptors can influence both the duration and the specificity of the signal emitted. We have investigated the mechanisms of internalization of fibroblast growth factor receptor 3 (FGFR3) and compared it to that of FGFR1 which is internalized predominantly through clathrin-mediated endocytosis. Interestingly, we observed that FGFR3 was internalized at a slower rate than FGFR1 indicating that it may use a different endocytic mechanism than FGFR1. Indeed, after depletion of cells for clathrin, internalization of FGFR3 was only partly inhibited while endocytosis of FGFR1 was almost completely abolished. Similarly, expression of dominant negative mutants of dynamin resulted in partial inhibition of the endocytosis of FGFR3 whereas internalization of FGFR1 was blocked. Interfering with proposed regulators of clathrin-independent endocytosis such as Arf6, flotillin 1 and 2 and Cdc42 did not affect the endocytosis of FGFR1 or FGFR3. Furthermore, depletion of clathrin decreased the degradation of FGFR1 resulting in sustained signalling. In the case of FGFR3, both the degradation and the signalling were only slightly affected by clathrin depletion. The data indicate that clathrin-mediated endocytosis is required for efficient internalization and downregulation of FGFR1 while FGFR3, however, is internalized by both clathrin-dependent and clathrin-independent mechanisms
Nonlinear normal modes of a self-excited system driven by parametric and external excitations
Tailored ß-Cyclodextrin Blocks the Translocation Pores of Binary Exotoxins from C. Botulinum and C. Perfringens and Protects Cells from Intoxication
International audienceBackgroundClostridium botulinum C2 toxin and Clostridium perfringens iota toxin are binary exotoxins, which ADP-ribosylate actin in the cytosol of mammalian cells and thereby destroy the cytoskeleton. C2 and iota toxin consists of two individual proteins, an enzymatic active (A-) component and a separate receptor binding and translocation (B-) component. The latter forms a complex with the A-component on the surface of target cells and after receptor-mediated endocytosis, it mediates the translocation of the A-component from acidified endosomal vesicles into the cytosol. To this end, the B-components form heptameric pores in endosomal membranes, which serve as translocation channels for the A-components.Here we demonstrate that a 7-fold symmetrical positively charged ß-cyclodextrin derivative, per-6-S-(3-aminomethyl)benzylthio-ß-cyclodextrin, protects cultured cells from intoxication with C2 and iota toxins in a concentration-dependent manner starting at low micromolar concentrations. We discovered that the compound inhibited the pH-dependent membrane translocation of the A-components of both toxins in intact cells. Consistently, the compound strongly blocked transmembrane channels formed by the B-components of C2 and iota toxin in planar lipid bilayers in vitro. With C2 toxin, we consecutively ruled out all other possible inhibitory mechanisms showing that the compound did not interfere with the binding of the toxin to the cells or with the enzyme activity of the A-component.Conclusions/SignificanceThe described ß-cyclodextrin derivative was previously identified as one of the most potent inhibitors of the binary lethal toxin of Bacillus anthracis both in vitro and in vivo, implying that it might represent a broad-spectrum inhibitor of binary pore-forming exotoxins from pathogenic bacteria
The Flux-Line Lattice in Superconductors
Magnetic flux can penetrate a type-II superconductor in form of Abrikosov
vortices. These tend to arrange in a triangular flux-line lattice (FLL) which
is more or less perturbed by material inhomogeneities that pin the flux lines,
and in high- supercon- ductors (HTSC's) also by thermal fluctuations. Many
properties of the FLL are well described by the phenomenological
Ginzburg-Landau theory or by the electromagnetic London theory, which treats
the vortex core as a singularity. In Nb alloys and HTSC's the FLL is very soft
mainly because of the large magnetic penetration depth: The shear modulus of
the FLL is thus small and the tilt modulus is dispersive and becomes very small
for short distortion wavelength. This softness of the FLL is enhanced further
by the pronounced anisotropy and layered structure of HTSC's, which strongly
increases the penetration depth for currents along the c-axis of these uniaxial
crystals and may even cause a decoupling of two-dimensional vortex lattices in
the Cu-O layers. Thermal fluctuations and softening may melt the FLL and cause
thermally activated depinning of the flux lines or of the 2D pancake vortices
in the layers. Various phase transitions are predicted for the FLL in layered
HTSC's. The linear and nonlinear magnetic response of HTSC's gives rise to
interesting effects which strongly depend on the geometry of the experiment.Comment: Review paper for Rep.Prog.Phys., 124 narrow pages. The 30 figures do
not exist as postscript file
Simple and clear evidence for positive feedback limitation by bipolar behavior during scanning electrochemical microscopy of unbiased conductors
On the basis of an experimentally validated simple theoretical
model, it is demonstrated unambiguously that when an unbiased
conductor is probed by a scanning electrochemical tip (scanning electrochemical
microscopy, SECM), it performs as a bipolar electrode. Though
already envisioned in most recent SECM theories, this phenomenon is
generally overlooked in SECM experimental investigations. However, as is
shown here, this may alter significantly positive feedback measurements
when the probed conductor is not much larger than the ti
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