Preliminary results on the verification of the water balance aspects of the regcm3 regional climate model on yearly scales

In this report some preliminary results obtained implementing the RegCM3 regional climate model to downscale, at the relatively high horizontal spatial resolution of about 25km, one year (the 1982) of the ECMWF ERA40 reanalysis in the Western Europe and Mediterranean area, are discussed. The main aim of this work is to assess the performance of the RegCM3 describing the runoff (R), the precipitation (P) and the evapotranspiration (E) components of the hydrological budget. This has been made comparing the monthly precipitation averages for 1982 against a gridded dataset, at spatial resolution of 0.5, of measured data (CRU dataset) and then checking physical consistency of the simulated P field with the corresponding R and E fields

Open CASCADE and rapid prototyping in human carotid lumen reconstruction

Image processing algorithms, CAD-CAM tools and rapid prototyping (RP) techniques are able to produce complex lumen artery replicas. This work presents a system for manufacturing the lumen of human carotid from computed tomography acquisition. The pipe-line of manufacturing process of a human carotid lumen replication is presented. Each stage of the pipe-line is briefly discussed. Technical details of the 3D surface reconstruction phase, based on the Open Cascade geometric modelling software, and the RP manufaturing process based on Fused Deposition Modelling are presented

PREMIAGRID: previsioni meteorologiche probabilistiche in ambiente GRID

2006-11-28Sardegna Ricerche, Edificio 2, Località Piscinamanna 09010 Pula (CA) - ItaliaKick-off Meeting del Progetto GRIDA

Sistemi informatici avanzati per l'analisi stratigrafica archeologica

Questo documento descrive le potenzialità derivanti dall’applicazione di affermate tecniche e metodologie ICT nell’ambito dell’indagine di siti archeologici. Queste metodologie sono organizzate in una architettura di sistema informativo adeguato a supportare l’attività dell’archeologo per la ricerca, la didattica e la fruizione. L’architettura proposta cerca di estendere le potenzialità d’uso delle metodologie di analisi non distruttiva, delle tecniche di ricostruzione di geometrie di reperti, e delle tecniche di prototipazione rapida per la manifattura di reperti, utilizzati principalmente nella diagnosi e restauro di beni culturali, ad ambiti più estesi quali l’analisi stratigrafica archeologica. L’architettura si basa sugli strumenti software ed ambienti di sviluppo sperimentati nel Progetto Laboratorio Avanzato per la Progettazione e la Simulazione al Calcolatore

Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined Groups

Lung neuroendocrine neoplasms (LNENs) classes, as proposed by the World Health Organization 2015, do not provide properly prognostic and therapeutic indications. In fact, high-throughput molecular analysis, based on next-generation sequencing, identified novel molecular subgroups, associated with different genomic signatures, that could pave the way for alternative therapeutic approaches. The present review, coupled with in silico molecular analysis, could show the current genomic alterations state in actual LNENS groups. Interestingly our manuscript suggests that the molecular novelties could improve the LNENs therapeutics efficacy. In more detail, we reported the differences of gene alterations and mutational rate between LNENS, confirming the central pathogenetic role given by a different mutational rate in chromatin remodeling genes and tumor suppressors TP53-RB1. In conclusion, our results underlined that a further molecular layer is needed to improve the efficacy of LNENs medical treatment.Lung neuroendocrine neoplasms (LNENs) represent a rare and heterogeneous population of lung tumors. LNENs incidence rate has increased dramatically over the past 30 years. The current World Health Organization LNENs classification (WHO 2015), distinguished four LNENs prognostic categories, according to their morphology, necrosis amount and mitotic count: typical carcinoid (TC), atypical-carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC). At present, due to their rarity and biological heterogeneity there is still no consensus on the best therapeutic approach. Next-generation-sequencing analysis showed that WHO 2015 LNENs classes, could be characterized also by specific molecular alterations: frequently mutated genes involving chromatin remodeling and generally characterized by low mutational burden (MB) are frequently detected in both TC and AC; otherwise, TP53 and RB1 tumor suppressor genes alterations and high MB are usually detected in LCNEC and SCLC. We provide an overview concerning gene mutations in each WHO 2015 LNENs class in order to report the current LNENs mutational status as potential tool to better understand their clinical outcome and to drive medical treatment

GRIDA3—a shared resources manager for environmental data analysis and applications

GRIDA3 (Shared Resources Manager for Environmental Data Analysis and Applications) is a multidisciplinary project designed to deliver an integrated system to forge solutions to some environmental challenges such as the constant increase of polluted sites, the sustainability of natural resources usage and the forecast of extreme meteorological events. The GRIDA3 portal is mainly based on Web 2.0 technologies and EnginFrame framework. The portal, now at an advanced stage of development, provides end-users with intuitive Web-interfaces and tools that simplify job submission to the underneath computing resources. The framework manages the user authentication and authorization, then controls the action and job execution into the grid computing environment, collects the results and transforms them into an useful format on the client side. The GRIDA3 Portal framework will provide a problem-solving platform allowing, through appropriate access policies, the integration and the sharing of skills, resources and tools located at multiple sites across federated domains

Physical human lumen carotid reconstruction: life-size models by rapid prototyping

Poster of SPIE Conference held in San Diego - CA, USA, 10/15 FebruaryRapid Prototyping (RP) is a technique used in industry for manufacturing prototypes. Its capability to physically reproduce geometrical complex shapes is getting increasing interest in many fields of medicine. In the field of vascular surgery, replicas of artery lumen have utility in complex cases or when standard imaging is felt to be equivocal. Replicas can also facilitate experimental studies of computational vascular fluid-dynamics permitting in-vitro reproductions of blood flow in living subjects before and after surgery. The VIrtual VAscular (VIVA) project at CRS4, developed a system able to process three-dimensional (3D) datasets extracted from a Computer Tomography (CT) apparatus, visualize them, reconstruct the geometry of arteries of specific patients, and simulate blood flow in them. In our work, the applicability of RP techniques to VIVA’s real size replicas of an autoptic carotid vessel lumen is presented and an overview of the RP based system developed is provided. The techniques used in our prototype are discussed and experimental results for the creation of a human carotid lumen replica are analysed. We discuss in detail the pipeline of the manufacturing process: 3D geometric reconstruction from segmented points, geometry tessellation, STL (Stereo Lithography format) conversion. Moreover we illustrate some technical details of the specific RP technique called Fused Deposition Modelling (FDM), used to build the lumen replicas, the materials used for prototypes, throughput time and costs of the FDM models realized. The system is totally based on open-source software. This enables us to control each step of the pipeline, from data acquisition to STL export file. In this context, we present main sources of error encountered during all manufacturing process stages