Formulation and Assessment of an Instant Degrading Film of the Poorly Soluble Medicament Cilnidipine

Cilnidipine, also known as dihydropyridine, is a calcium antagonist that has that chemical formula. It does this by blocking L-type calcium channels, which prevents calcium from entering the capillaries. This results in a reduction in blood pressure. When taken orally in tablet form, the medicine has a lower bioavailability than when it is injected. This is because it is less water-soluble. A substance was produced as a result of the combination of PEG 400 and propylene glycol that was neither hard nor sticky in nature. Inclusion complexes that are produced with cyclodextrin contribute to an improvement in the drug\u27s solubility and release. We studied the influence that PEG 400 and propylene glycol would have on the formula by using a factorial arrangement. A 32-full factorial design was utilised in order to attain the maximum level of optimization for the rapidly disintegrating film. In in vitro drug release investigations using PEG 400 and propylene glycol, independent parameters such as pH, thickness, weight uniformity, percent drug content, folding endurance, and disintegration time were examined and analysed

Recent advances for commedonal acne treatment by employing lipid nanocarriers topically

Acne is one of the most common chronic inflammatory dermatological disorder associated with multifactorial pathogenesis. Approximately 95 % of the population suffers from it at some point in their lifetime. Antibiotics, acids, benzoyl peroxide, and retinoids are the most commonly drugs used for the treatment of acne. However, conventional formulations of these drugs are associated with undesirable toxicities, inadequate penetration across stratum corneum, short retention time of the drug in the target site, and poor aqueous solubility of drugs, that limited their medicinal applications. As a consequence pharmaceutical researchers are turning towards novel drug delivery systems to overcome these limitations.With respect to their small particle size, lipid occlusive nature and unique surface characteristics, lipid nanocarriers can promote skin hydration, enhance drug permeation, improve its targeting properties and retention time on the skin, increase drug solubility and protect it from degradation, provide sustained drug release and reduce dosing frequency. The current review summarizes the better nanotechnological systems that can be used in future for better and effective treatment of acne

An updated review on morpholine derivatives with their pharmacological actions

The invention of newer chemical entities, which have some therapeutically worth is always a great challenge. It is no doubt that it is a lengthier process. We have several drugs in the market for treatment of wide variety of diseases. The marketed drugs available may be heterocyclic or non-heterocyclic derivatives. Always it was found that heterocyclic derivatives have wide variety of pharmacological activity. The intension of this review is to highlight one of the important heterocyclic rings i.e.: Morpholine. Several works have been done on this nucleus, which should be enlighten for more and more applicability

Formulation and evaluation of sustained release tablets of propranolol hydrochloride

The main objective of sustained release drug delivery system is to provide a steady state blood plasma level concentration which is non-toxic and therapeutically active for a longer period of time. Owing its increased patient compliance and prolonged release of action in delivering drugs several benefits can be contemplated in delivering of sustained release dosage form[1]. Among various route of drug delivery Sustained release drug delivery is most widely preferred as it’s less frequency of dosing and controls the release of drugs. Natural polymers are biodegradable and nontoxic in nature with reduced side effects. It is also eco-friendly and safe to be administered as compared to synthetic polymers. The current work was based on preparation of sustained release tablets of Propranolol Hydrochloride using natural polymers like Gum Acacia, Hibiscus Rosasinesis and Microcrystalline cellulose. Presently much attention is being paid for formulation of sustained release tablets that contains matrix system. Direct compression method was used for formulation of sustained release tablets of Propranolol Hydrochloride. The prepared tablets were evaluated for different pre-formulation studies and in vitro dissolution studies were performed using USP-III dissolution apparatus. Dissolution studies of different formulations were evaluated for 24 hours at 370C

Sars-COV-2 infection leads to neurodegenerative or neuropsychiatric diseases

The current COVID-19 epidemic caused by the new SARS-CoV-2 has severely harmed global healthcare (severe acute respiratory syndrome coronavirus). COVID-19's pulmonary and cardiovascular effects have been known from its inception, but its causes, mechanisms, and neuropath logical consequences remain unknown. Our research focused on neurological problems in COVID-19 patients, as well as probable SARS-CoV-2 infection routes like hematogenous, direct/neuronal, lymphatic tissue, cerebrospinal fluid, or infiltration by infected immune cells. Late December 2019 in Wuhan, China, a mysterious viral pneumonia struck. The disease was caused by a new corona virus. Corona virus infection spread rapidly from person to person in 2019. The WHO has called it a global public health emergency (WHO). Activation of NF-B in SARS-CoV-2 infection may be linked to immune cell pathogenicity, cytokine storms, and multi-organ failure. COVID-19's inhibition of the NF-B signaling pathway shows promising therapeutically. Inhibiting IKK phosphorylation, a critical downstream consequence of the NF-B signaling cascade, reduces COVID-19 levels. All three disorders have been linked to COVID-19 gene mutations. This study provides a biological basis for future research on COVID-19-related neurological disease.

SATB1-Binding Sequences and Alu-Like Motifs Define a Unique Chromatin Context in the Vicinity of Human Immunodeficiency Virus Type 1 Integration Sites▿

Retroviral integration has recently been shown to be nonrandom, favoring transcriptionally active regions of chromatin. However, the mechanism for integration site selection by retroviruses is not clear. We show here the occurrence of Alu-like motifs in the sequences flanking the reported viral integration sites that are significantly different from those obtained from the randomly picked sequences from the human genome, suggesting that unique primary sequence features exist in the genomic regions targeted by human immunodeficiency virus type 1 (HIV-1). Additionally, these sequences were preferentially bound by SATB1, the T lineage-restricted chromatin organizer, in vitro and in vivo. Alu repeats make up nearly 10% of the human genome and have been implicated in the regulation of transcription. To specifically isolate sequences flanking the viral integration sites and also harboring both Alu-like repeats and SATB1-binding sites, we combined chromatin immunoprecipitation with sequential PCRs. The cloned sequences flanking HIV-1 integration sites were specifically immunoprecipitated and amplified from the pool of anti-SATB1-immunoprecipitated genomic DNA fragments isolated from HIV-1 NL4.3-infected Jurkat T-cell chromatin. Moreover, many of these sequences were preferentially partitioned in the DNA associated tightly with the nuclear matrix and not in the chromatin loops. Strikingly, many of these regions were disfavored for integration when SATB1 was silenced, providing unequivocal evidence for its role in HIV-1 integration site selection. We propose that definitive sequence features such as the Alu-like motifs and SATB1-binding sites provide a unique chromatin context in vivo which is preferentially targeted by the HIV-1 integration machinery

Abstracts of National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020

This book presents the abstracts of the papers presented to the Online National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020 (RDMPMC-2020) held on 26th and 27th August 2020 organized by the Department of Metallurgical and Materials Science in Association with the Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, India. Conference Title: National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020Conference Acronym: RDMPMC-2020Conference Date: 26–27 August 2020Conference Location: Online (Virtual Mode)Conference Organizer: Department of Metallurgical and Materials Engineering, National Institute of Technology JamshedpurCo-organizer: Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, IndiaConference Sponsor: TEQIP-