Triple X syndrome: a rare case entity with premature ovarian failure, recurrent abortion and secondary infertility

Triple X syndrome is a sex chromosome abnormality characterised by extra X chromosome, occurring in 1 in 1000 female births. This condition often remains undiagnosed as most of them have normal phenotype, puberty and fertility. We report a case of Triple X syndrome with normal phenotype and intelligence presented with premature ovarian failure, recurrent abortion and secondary infertility. This case emphasizes the need for chromosomal analysis in women presenting with premature ovarian failure leading to recurrent abortion and secondary infertility

Nano-biotechnology in tumour and cancerous disease: A perspective review

In recent years, drug manufacturers and researchers have begun to consider the nanobiotechnology approach to improve the drug delivery system for tumour and cancer diseases. In this article, we review current strategies to improve tumour and cancer drug delivery, which mainly focuses on sustaining biocompatibility, biodistribution, and active targeting. The conventional therapy using cornerstone drugs such as fludarabine, cisplatin etoposide, and paclitaxel has its own challenges especially not being able to discriminate between tumour versus normal cells which eventually led to toxicity and side effects in the patients. In contrast to the conventional approach, nanoparticle-based drug delivery provides target-specific delivery and controlled release of the drug, which provides a better therapeutic window for treatment options by focusing on the eradication of diseased cells via active targeting and sparing normal cells via passive targeting. Additionally, treatment of tumours associated with the brain is hampered by the impermeability of the blood–brain barriers to the drugs, which eventually led to poor survival in the patients. Nanoparticle-based therapy offers superior delivery of drugs to the target by breaching the blood–brain barriers. Herein, we provide an overview of the properties of nanoparticles that are crucial for nanotechnology applications. We address the potential future applications of nanobiotechnology targeting specific or desired areas. In particular, the use of nanomaterials, biostructures, and drug delivery methods for the targeted treatment of tumours and cancer are explored.Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) del Gobierno de Canarias, Grant/Award Number: Project ProID2020010134; Fundación CajaCanarias, Grant/Award Number: Project 2019SP43; State Plan for Scientific, Technical Research and Innovation 2021–2023 from the Spanish Ministry of Science and Innovation, Grant/Award Number: ProjectPLEC2022-009507Peer reviewe

Nagpur.

Abstract- Research problems are to enhance an Intrusion Detection System (IDS) of a clustered HWSN to prolong its lifetime operation in the presence of unreliable and malicious nodes. Also, to address the energy consumption and QoS gain in reliability, delay and security with the goal to maximize the lifetime of a clustered HWSN while satisfying application QoS requirements in the context of multipath routing. The proposed research is a highly scalable cluster-based hierarchical trust management protocol for wireless sensor networks (WSNs) to effectively deal with selfish or malicious nodes. The proposed work consider multidimensional trust attributes derived from communication and social networks to evaluate the overall trust of a sensor node. System describes a heterogeneous WSN comprising a large number of sensor nodes with vastly different social and quality of service (QoS) behaviors with the objective t

Triple X syndrome: a rare case entity with premature ovarian failure, recurrent abortion and secondary infertility

Triple X syndrome is a sex chromosome abnormality characterised by extra X chromosome, occurring in 1 in 1000 female births. This condition often remains undiagnosed as most of them have normal phenotype, puberty and fertility. We report a case of Triple X syndrome with normal phenotype and intelligence presented with premature ovarian failure, recurrent abortion and secondary infertility. This case emphasizes the need for chromosomal analysis in women presenting with premature ovarian failure leading to recurrent abortion and secondary infertility