7,951 research outputs found
DC field induced enhancement and inhibition of spontaneous emission in a cavity
We demonstrate how spontaneous emission in a cavity can be controlled by the
application of a dc field. The method is specially suitable for Rydberg atoms.
We present a simple argument for the control of emission.Comment: 3-pages, 2figure. accepted in Phys. Rev.
Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway
Circulating levels of chylomicron remnants (CMRs) increase postprandially and their composition directly reflects dietary lipid intake. These TG-rich lipoproteins likely contribute to the development of endothelial dysfunction, albeit via unknown mechanisms. Here, we investigated how the FA composition of CMRs influences their actions on human aortic endothelial cells (HAECs) by comparing the effects of model CMRs—artificial TG-rich CMR-like particles (A-CRLPs)—containing TGs extracted from fish, DHA-rich algal, corn, or palm oils. HAECs responded with distinct transcriptional programs according to A-CRLP TG content and oxidation status, with genes involved in antioxidant defense and cytoprotection most prominently affected by n-3 PUFA-containing A-CRLPs. These particles were significantly more efficacious inducers of heme oxygenase-1 (HO-1) than n-6 PUFA corn or saturated FA-rich palm CRLPs. Mechanistically, HO-1 induction by all CRLPs requires NADPH oxidase 4, with PUFA-containing particles additionally dependent upon mitochondrial reactive oxygen species. Activation of both p38 MAPK and PPARβ/δ culminates in increased nuclear factor erythroid 2-related factor 2 (Nrf2) expression/nuclear translocation and HO-1 induction. These studies define new molecular pathways coupling endothelial cell activation by model CMRs with adaptive regulation of Nrf2-dependent HO-1 expression and may represent key mechanisms through which dietary FAs differentially impact progression of endothelial dysfunction
A survey for redshifted molecular and atomic absorption lines - II. Associated HI, OH and millimetre lines in the z >~ 3 Parkes quarter-Jansky flat-spectrum sample
We present the results of a z>2.9 survey for HI 21-cm and molecular
absorption in the hosts of radio quasars using the GMRT and the Tidbinbilla
70-m telescope. Previously published searches, which are overwhelmingly at
redshifts of z<1, exhibit a 42% detection rate (31 out of 73 sources), and the
inclusion of our survey yields a 17% detection rate (2 out of 12 sources) at
z>2.5. We therefore believe that our high redshift selection is responsible for
our exclusive non-detections, and find that at ultra-violet luminosities of
>10e23 W/Hz, 21-cm absorption has never been detected. We also find this to not
only apply to our targets, but also those at low redshift exhibiting similar
luminosities, giving zero detections out of a total of 16 sources over z=0.24
to 3.8. This is in contrast to the < 10e23 W/Hz sources where there is a near
50% detection rate of 21-cm absorption.
The mix of 21-cm detections and non-detections is currently attributed to
orientation effects, where according to unified schemes of active galactic
nuclei, 21-cm absorption is more likely to occur in sources designated as radio
galaxies (type-2 objects, where the nucleus is viewed through dense obscuring
circumnuclear gas) than in quasars(type-1 objects, where we have a direct view
to the nucleus). However, due to the exclusively high ultra-violet luminosities
of our targets it is not clear whether orientation effects alone can wholly
account for the distribution, although there exists the possibility that the
large luminosities are indicative of a changing demographic of galaxy types. We
also find that below luminosities of ~10e23 W/Hz, both type-1 and type-2
objects have a 50% likelihood of exhibiting 21-cm absorption.Comment: 21 pages, accepted by MNRA
High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F-2 alpha concentrations relative to a control high-oleic acid meal: a randomized controlled trial
Background: Eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplementation has beneficial cardiovascular effects, but postprandial influences of these individual fatty acids are unclear. Objectives: The primary objective was to determine the vascular effects of EPA + DHA compared with DHA only during postprandial lipemia relative to control high–oleic acid meals; the secondary objective was to characterize the effects of linoleic acid–enriched high-fat meals relative to the control meal. Design: We conducted a randomized, controlled, double-blind crossover trial of 4 high-fat (75-g) meals containing 1) high–oleic acid sunflower oil (HOS; control), 2) HOS + fish oil (FO; 5 g EPA and DHA), 3) HOS + algal oil (AO; 5 g DHA), and 4) high–linoleic acid sunflower oil (HLS) in 16 healthy men (aged 35–70 y) with higher than optimal fasting triacylglycerol concentrations (mean ± SD triacylglycerol, 1.9 ± 0.5 mmol/L). Results: Elevations in triacylglycerol concentration relative to baseline were slightly reduced after FO and HLS compared with the HOS control (P < 0.05). The characteristic decrease from baseline in plasma nonesterified fatty acids after a mixed meal was inhibited after AO (Δ 0–3 h, P < 0.05). HLS increased the augmentation index compared with the other test meals (P < 0.05), although the digital volume pulse–reflection index was not significantly different. Plasma 8-isoprostane F(2α) analysis revealed opposing effects of FO (increased) and AO (reduced) compared with the control (P < 0.05). No differences in nitric oxide metabolites were observed. Conclusions: These data show differential postprandial 8-isoprostane F(2α) responses to high-fat meals containing EPA + DHA–rich fish oil compared with DHA-rich AO, but these differences were not associated with consistent effects on postprandial vascular function or lipemia. More detailed analyses of polyunsaturated fatty acid–derived lipid mediators are required to determine possible divergent functional effects of single meals rich in either DHA or EPA. This trial was registered at clinicaltrials.gov as NCT01618071
Current noise of a quantum dot p-i-n junction in a photonic crystal
The shot-noise spectrum of a quantum dot p-i-n junction embedded inside a
three-dimensional photonic crystal is investigated. Radiative decay properties
of quantum dot excitons can be obtained from the observation of the current
noise. The characteristic of the photonic band gap is revealed in the current
noise with discontinuous behavior. Applications of such a device in
entanglement generation and emission of single photons are pointed out, and may
be achieved with current technologies.Comment: 4 pages, 3 figures, to appear in Phys. Rev. B (2005
Phenotypic heterogeneity of peripheral monocytes in healthy dogs
Monocytes are key cells of the innate immune system. Their phenotypic and functional roles have been investigated in humans, mice and other animals, such as the rat, pig and cow. To date, detailed phenotypic analysis of monocytes has not been undertaken in dogs. Two important surface markers in human monocytes are CD14 and MHC class II (MHC II). By flow cytometry, we demonstrated that canine monocytes can be subdivided into three separate populations: CD14posMHC IIneg, CD14posMHC IIpos and CD14negMHC IIpos. Both light and transmission electron microscopy confirmed the monocytic identity of all three populations. The CD14posMHC IIneg population could be distinguished on an ultrastructural level by their smaller size, the presence of more numerous, larger granules, and more pseudopodia than both of the other populations
A Simplest Swimmer at Low Reynolds Number: Three Linked Spheres
We propose a very simple one-dimensional swimmer consisting of three spheres
that are linked by rigid rods whose lengths can change between two values. With
a periodic motion in a non-reciprocal fashion, which breaks the time-reversal
symmetry as well as the translational symmetry, we show that the model device
can swim at low Reynolds number. This model system could be used in
constructing molecular-size machines
Inequalities for electron-field correlation functions
I show that there exists a class of inequalities between correlation
functions of different orders of a chaotic electron field. These inequalities
lead to the antibunching effect and are a consequence of the fact that
electrons are fermions -- indistinguishable particles with antisymmetric
states. The derivation of the inequalities is based on the known form of the
correlation functions for the chaotic state and on the properties of matrices
and determinants.Comment: 8 pages Latex2e, 2 eps figure
Graduate dress code: How undergraduates are planning to use hair, clothes and make-up to smooth their transition to the workplace
This article explores the relationship between students’ identities, their ideas about professional appearance and their anticipated transition to the world of work. It is based on a series of semi-structured interviews with 13 students from a vocationally-focused university in England. It was found that participants viewed clothing and appearance as an important aspect of their transition to the workplace. They believed that, if carefully handled, their appearance could help them to fit in and satisfy the expectations of employers, although some participants anticipated that this process of fitting in might compromise their identity and values. The article addresses students’ anticipated means of handling the tension between adapting to a new environment and ‘being themselves’. It is argued that the way this process is handled is intertwined with wider facets of identity – most notably those associated with gender.The article is based on research funded by the University of Derby. © 2015 IP Publishing Ltd. ((http://www.ippublishing.com). Reproduced by permission
Magnetic field induced lattice anomaly inside the superconducting state of CeCoIn: evidence of the proposed Fulde-Ferrell-Larkin-Ovchinnikov state
We report high magnetic field linear magnetostriction experiments on
CeCoIn single crystals. Two features are remarkable: (i) a sharp
discontinuity in all the crystallographic axes associated with the upper
superconducting critical field that becomes less pronounced as the
temperature increases; (ii) a distinctive second order-like feature observed
only along the c-axis in the high field (10 T ) low
temperature ( 0.35 K) region. This second order transition is
observed only when the magnetic field lies within 20 of the ab-planes and
there is no signature of it above , which raises questions regarding
its interpretation as a field induced magnetically ordered phase. Good
agreement with previous results suggests that this anomaly is related to the
transition to the Fulde-Ferrel-Larkin-Ovchinnikov superconducting state.Comment: 3 figures, 5 page
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