Protective effects elicited by cow milk fermented with L. Paracasei CBAL74 against SARS-CoV-2 infection in human enterocytes

Fermented foods have been proposed in limiting SARS-CoV-2 infection. Emerging evidence suggest the efficacy of cow's milk fermented with the probiotic L. paracasei CBAL74 (FM-CBAL74) in preventing infectious diseases. We evaluated the protective action of FM-CBAL74 against SARS-CoV-2 infection in human enterocytes. Relevant aspects of SARS-CoV-2 infection were assessed: infectivity, host functional receptor angiotensin-converting enzyme-2 (ACE2), transmembrane protease serine 2 (TMPRSS2), and pro-inflammatory cytokines expression (IL-6, IL-15, IL-1β, VEGFβ, TNF-α, MCP-1, CXCL1). Pre-incubation with FM-CBA L74 reduced the number of infected cells. The expression of ACE2 and the pro-inflammatory cytokines IL-6, VEGFβ, IL-15, IL-1β was downregulated by the pre-treatment with this fermented food. No effect on TMPRSS2, MCP-1, TNF-α and CXCL1 expression was observed. Modulating the crucial aspects of the infection, the fermented food FM-CBAL74 exerts a preventive action against SARS-CoV-2. These evidence could pave the way to innovative nutritional strategy to mitigate the COVID-19

La marginalità a Piacenza e nel suo circondario nella tarda età napoleonica (1810-1814)

This paper wants to be a frame about the situation of poorest people in Piacenza during the late Napoleonic age (1810-1814). In that period the French domination replaced the catholic Church in the assistance and caring of people in need, organizing a State service. To complete this transformation, they used part of the money raised by ecclesiastic dispossession, principally lands and monasteries. Today we can study this period of transformations thanks to the administrative efficiency of the French domination whom registered a lot of information about the social marginality’s phenomenon. The French domination brought an important modernization of social and economic sectors in the modern history of both Piacenza and Italy; it also brought an exploitation related to the European hegemony’s project pursued by Napoleon

Meningeoma associado a aneurisma relato de um caso

Relata-se o caso de paciente com (aneurisma da região da comunicante posterior e meningeoma da goteira olfativa. A paciente foi operada, sendo tratadas ambas as patologias no mesmo ato cirúrgico e obtendo-se resultado satisfatório

From Sarmiento to Borges: The Construction of an Intellectual Lineage in the Magazine Punto de vista

This article analyses the revision of the Argentine intellectual tradition demonstrated in the magazine Punto de vista throughout its first nineteen issues, published during the last Argentine dictatorship (1976–1983). From Sarmiento and the generation of 1837 to Borges and the Sur generation, the reassessment of Argentine intellectuals' legacies set out by editors of Punto de vista was an explicit attempt to insert the magazine into a recognised intellectual lineage. At the same time, it responded to a search for identity prompted by the critical and repressive context in which the magazine was first published