Encadré 2. Laissez nos bibliothèques en paix ! : extraits

Nous proposons quelques extraits, traduits pour cette édition, du discours prononcé le 20 janvier 2011 par Philip Pullman lors d’une réunion qui a fait salle comble, organisée pour la défense des bibliothèques de l’Oxfordshire. « Le gouvernement, en la personne de M. Eric Pickles, véritable personnage de Dickens, a sabré le budget alloué aux collectivités locales, tout en leur confiant la responsabilité de réaliser des économies. Certaines d’entre elles ont réagi avec enthousiasme, d’autres m..

Bibliothèques publiques britanniques contemporaines

Cet ouvrage se propose de revenir sur les fermetures massives, depuis 2010, des bibliothèques publiques en Grande-Bretagne. Quelle a été la chronologie des plus de 300 fermetures de sites ? Comment en comprendre l’histoire et les logiques ? Pour la première fois accessible aux lecteurs français, une documentation spécialisée, traduite et éditorialisée, permet de comprendre les enjeux du débat sur la lecture publique dans un pays historiquement fer de lance pour son réseau de bibliothèques. Dirigé par Cécile Touitou, assistée de Karine Lespinasse, le livre réunit un collectif d’auteurs experts, français et britanniques

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.

Abstract BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy. RESULTS: In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disease) were followed for a median of 3.2 years (interquartile range, 2.2 to 4.4). A primary composite outcome event occurred in 839 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91; 95% confidence interval [CI], 0.83 to 1.00), with the intention-to-treat analysis indicating that exenatide, administered once weekly, was noninferior to placebo with respect to safety (P<0.001 for noninferiority) but was not superior to placebo with respect to efficacy (P=0.06 for superiority). The rates of death from cardiovascular causes, fatal or nonfatal myocardial infarction, fatal or nonfatal stroke, hospitalization for heart failure, and hospitalization for acute coronary syndrome, and the incidence of acute pancreatitis, pancreatic cancer, medullary thyroid carcinoma, and serious adverse events did not differ significantly between the two groups. CONCLUSIONS: Among patients with type 2 diabetes with or without previous cardiovascular disease, the incidence of major adverse cardiovascular events did not differ significantly between patients who received exenatide and those who received placebo. (Funded by Amylin Pharmaceuticals; EXSCEL ClinicalTrials.gov number, NCT01144338 .)

TEROPONG CAHAYA

624 hlm;15 x 23 c

Lyra's Oxford

Lyra's Oxford opens two years after the conclusion of Philip Pullman's The Amber Spyglass in the comfort and familiarity of Jordan College, where Lyra and her daemon, Pantalaimon, sit on the sun-drenched roof looking out over all of Oxford. But their peace is shattered when a strange bird - a witch's daemon, on it's own - tumbles out of the sky, in search of a healing elixer to cure his witch of a strange new disease. Lyra and Pan decided to help - witches are friends, of course - but the closer their winding walk leads them towards the infamous Oxford alchemist, the stronger Lyra's sense that something is amiss

KOMPAS EMAS

504 hlm;15 x 23 c

Northern Lights

"Without this child, we shall all die." Lyra Belacqua and her animal daemon live half-wild and carefree among scholars of Jordan College, Oxford. The destiny that awaits her will take her to the frozen lands of the Arctic, where witch-clans reign and ice-bears fight. Her extraordinary journey will have immeasurable consequnces far beyond her own world

PISAU GAIB

408 hlm;15 x 23 c