Genetic Engineering and the Pursuit of Human Perfection

The idea of perfection has always captivated the attention of people across the ages. Whether in the form of gods, nature, or role models, people have always looked towards some form of the purest ideal. Perfection is not a novel idea by any means; however, it is only in recent years that human beings have actually sought to achieve it

Genetic Engineering and the Pursuit of Human Perfection

The idea of perfection has always captivated the attention of people across the ages. Whether in the form of gods, nature, or role models, people have always looked towards some form of the purest ideal. Perfection is not a novel idea by any means; however, it is only in recent years that human beings have actually sought to achieve it

Genetic Engineering and the Pursuit of Human Perfection

The idea of perfection has always captivated the attention of people across the ages. Whether in the form of gods, nature, or role models, people have always looked towards some form of the purest ideal. Perfection is not a novel idea by any means; however, it is only in recent years that human beings have actually sought to achieve it

Birth Order and Humor Styles

Humor can be used in a multitude of ways. Previously, Rod Martin has developed four distinct categories of individual humor style, which describes the way in which an individual uses humor on an everyday basis. The four styles are affiliative, self-enhancing, aggressive, and self-deprecating. The question is what factors may be related to one’s humor style. It has been found that humor styles are correlated with one’s personality score on Five Factor Personality test. It has also been found that one’s order of birth is related to one’s personality. Therefore, it is reasonable to propose that one’s birth order may have a correlation with one’s style of humor. In the current research project, we aimed to investigate whether birth order is correlated to certain styles of humor. We predicted that the eldest child would show higher levels of self-enhancing humor, the middle child would show higher levels of affiliative humor, and the youngest child would show higher levels of self-deprecating humor. We are currently collecting data on student’s birth order and style of humor. Once the data has been collected and analyzed, statistical analysis will determine whether or not we should accept or reject the hypothesis. The data collection is still on going. We plan to present the preliminary results during the symposium

Chiral Reductions in the Salam-Sezgin Model

Reductions from six to four spacetime dimensions are considered for a class of supergravity models based on the six-dimensional Salam-Sezgin model, which is a chiral theory with a gauged U(1) R-symmetry and a positive scalar-field potential. Reduction on a sphere and monopole background of such models naturally yields four-dimensional theories without a cosmological constant. The question of chirality preservation in such a reduction has been a topic of debate. In this article, it is shown that the possibilities of dimensional reduction bifurcate into two separate consistent dimensional-reduction schemes. One of these retains the massless SU(2) vector gauge triplet arising from the sphere's isometries, but it produces a non-chiral four-dimensional theory. The other consistent scheme sets to zero the SU(2) gauge fields, but retains the gauged U(1) from six dimensions and preserves chirality although the U(1) is spontaneously broken. Extensions of the Salam-Sezgin model to include larger gauge symmetries produce genuinely chiral models with unbroken gauge symmetries.Comment: 37 page

RGS9-1 is required for normal inactivation of mouse cone phototransduction

Purpose: To test the hypothesis that Regulator of G-protein Signaling 9 (RGS9-1) is necessary for the normal inactivation of retinal cones. Methods: Mice having the gene RGS9-1 inactivated in both alleles (RGS9-1 -/-) were tested between the ages 8-10 weeks with electroretinographic (ERG) protocols that isolate cone-driven responses. Immunohistochemistry was performed with a primary antibody against RGS9-1 (anti-RGS9-1c), with the secondary conjugated to fluorescein isothiocyanate, and with rhodamine-conjugated peanut agglutinin. Results: (1) Immunohistochemistry showed RGS9-1 to be strongly expressed in the cones of wildtype (WT is C57BL/6) mice, but absent from the cones of RGS9-1 mice. (2) Cone-driven b-wave responses of dark-adapted RGS9-1 -/- mice had saturating amplitudes and sensitivities in the midwave and UV regions of the spectrum equal to or slightly greater than those of WT (C57BL/6) mice. (3) Cone-driven b-wave and a-wave responses of RGS9-1 -/- mice recovered much more slowly than those of WT after a strong conditioning flash: for a flash estimated to isomerize 1.2% of the M-cone pigment and 0.9% of the UV-cone pigment, recovery of 50% saturating amplitude was approximately 60-fold slower than in WT. Conclusions: (1) The amplitudes and sensitivities of the cone-driven responses indicate that cones and cone-driven neurons in RGS9-1 -/- mice have normal generator currents. (2) The greatly retarded recovery of cone-driven responses of RGS9-1 -/- mice relative to those of WT mice establishes that RGS9-1 is required for normal inactivation of the cone phototransduction cascades of both UV- and M-cones

High pressure Ca-VI phase between 158-180 GPa: Stability, electronic structure and superconductivity

We have performed ab initio calculations for new high-pressure phase of Ca-VI between 158-180 GPa. The study includes elastic parameters of mono- and poly-crystalline aggregates, electronic band structure, lattice dynamics and superconductivity. The calculations show that the orthorhombic Pnma structure is mechanically and dynamically stable in the pressure range studied. The structure is superconducting in the entire pressure range and the calculated Tc (~25K) is maximum at ~172 GPa, where the transfer of charges from 4s to 3d may be thought to be completed.Comment: 8 pages, 4 figures; PACS number(s): 74.70.Ad, 62.20.de, 71.20.-b, 74.20.Pq, 74.25.Kc, 74.62.Fj; Keywords: Calcium; High pressure; Electronic band structure; Phonon spectrum; Elastic constants; Superconducto

First Report of NRG Oncology/Radiation Therapy Oncology Group 0622: A Phase 2 Trial of Samarium-153 Followed by Salvage Prostatic Fossa Irradiation in High-Risk Clinically Nonmetastatic Prostate Cancer After Radical Prostatectomy.

PURPOSE: To investigate the utility of 153Sm lexidronam (Quadramet) in the setting of men with prostate cancer status post radical prostatectomy who develop biochemical failure with no clinical evidence of osseous metastases. PATIENTS AND METHODS: Trial NRG Oncology RTOG 0622 is a single-arm phase 2 trial that enrolled men with pT2-T4, N0-1, M0 prostate cancer status post radical prostatectomy, who meet at least 1 of these biochemical failure criteria: (1) prostate-specific antigen (PSA) \u3e 1.0 ng/mL; (2) PSA \u3e 0.2 ng/mL if Gleason score 9 to 10; or (3) PSA \u3e 0.2 ng/mL if N1. Patients received 153Sm (2.0 mCi/kg intravenously × 1) followed by salvage external beam radiation therapy (EBRT) to the prostatic fossa (64.8-70.2 Gy in 1.8-Gy daily fractions). No androgen deprivation therapy was allowed. The primary objective was PSA response within 12 weeks of receiving 153Sm. The secondary objectives were to: (1) assess the completion rate for the regimen of 153Sm and EBRT; (2) evaluate the hematologic toxicity and other adverse events (AEs) at 12 and 24 weeks; and (3) determine the freedom from progression rate at 2 years. RESULTS: A total of 60 enrolled eligible patients were included in this analysis. Median follow-up was 3.97 years. A PSA response was achieved in 7 of 52 evaluable patients (13.5%), compared with the 25% hypothesized. The 2-year freedom from progression rate was 25.5% (95% confidence interval 14.4%-36.7%), and the biochemical failure rate was 64.4% (95% CI 50.5%-75.2%). Samarium-153 was well tolerated, with 16 (of 60) grade 3 to 4 hematologic AEs and no grade 5 hematologic AEs. Radiation therapy was also well tolerated, with no grade 3 to 5 acute radiation therapy-related AEs and 1 grade 3 to 4 and no grade 5 late radiation therapy-related AEs. CONCLUSIONS: Trial NRG Oncology RTOG 0622 did not meet its primary endpoint of PSA response, although the regimen of 153Sm and salvage EBRT was well tolerated. Although the toxicity profile supports study of 153Sm in high-risk disease, it may not be beneficial in men receiving EBRT