19 research outputs found
Fundamental Principles in Bacterial Physiology - History, Recent progress, and the Future with Focus on Cell Size Control: A Review
Bacterial physiology is a branch of biology that aims to understand
overarching principles of cellular reproduction. Many important issues in
bacterial physiology are inherently quantitative, and major contributors to the
field have often brought together tools and ways of thinking from multiple
disciplines. This article presents a comprehensive overview of major ideas and
approaches developed since the early 20th century for anyone who is interested
in the fundamental problems in bacterial physiology. This article is divided
into two parts. In the first part (Sections 1 to 3), we review the first
`golden era' of bacterial physiology from the 1940s to early 1970s and provide
a complete list of major references from that period. In the second part
(Sections 4 to 7), we explain how the pioneering work from the first golden era
has influenced various rediscoveries of general quantitative principles and
significant further development in modern bacterial physiology. Specifically,
Section 4 presents the history and current progress of the `adder' principle of
cell size homeostasis. Section 5 discusses the implications of coarse-graining
the cellular protein composition, and how the coarse-grained proteome `sectors'
re-balance under different growth conditions. Section 6 focuses on
physiological invariants, and explains how they are the key to understanding
the coordination between growth and the cell cycle underlying cell size control
in steady-state growth. Section 7 overviews how the temporal organization of
all the internal processes enables balanced growth. In the final Section 8, we
conclude by discussing the remaining challenges for the future in the field.Comment: Published in Reports on Progress in Physics.
(https://doi.org/10.1088/1361-6633/aaa628) 96 pages, 48 figures, 7 boxes, 715
reference
Quantum Walk of Two Interacting Bosons
We study the effect of interactions on the bosonic two-particle quantum walk
and its corresponding spatial correlations. The combined effect of interactions
and Hanbury-Brown Twiss interference results in unique spatial correlations
which depend on the strength of the interaction, but not on its sign. The
results are explained in light of the two-particle spectrum and the physics of
attractively and repulsively bound pairs. We experimentally measure the weak
interaction limit of these effects in nonlinear photonic lattices. Finally, we
discuss an experimental approach to observe the strong interaction limit using
single atoms in optical lattices.Comment: 4 pages, 5 figures. Comments wellcom
Motional Broadening in Ensembles With Heavy-Tail Frequency Distribution
We show that the spectrum of an ensemble of two-level systems can be
broadened through `resetting' discrete fluctuations, in contrast to the
well-known motional-narrowing effect. We establish that the condition for the
onset of motional broadening is that the ensemble frequency distribution has
heavy tails with a diverging first moment. We find that the asymptotic
motional-broadened lineshape is a Lorentzian, and derive an expression for its
width. We explain why motional broadening persists up to some fluctuation rate,
even when there is a physical upper cutoff to the frequency distribution.Comment: 6 pages, 4 figure