12 research outputs found
Effect of specific inhibition of gamma-glutamyl transpeptidase on amino acid uptake by mammary gland of the lactating rat
Get PDFAbstractWe showed [Biochem. J. (1981) 194, 99–102] that inhibition of γ-glutamyl transpeptidase in vivo with serine-borate decreases amino acid uptake by mammary gland. However, doubts arose about the validity of this inhibitor in metabolic studies because it must be used in very large amounts. New Inhibitors have been isolated, like anthglutin and acivicin, which are effective at low concentrations in vivo. Here, we show that treatment of lactating rats with these substances decreases the transpeptidase activity and the amino acid uptake by the gland. These results support the hypothesis that the γ-glutamyl cycle functions as an amino acid transport system in mammary gland
Inhibition of placental γ-glutamyltransferase results in a decreased placental transfer of alanine
No full textMaintenance of GSH content in primary astrocyte cultures under oxidative stress conditions
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Maintenance of GSH content in primary astrocyte cultures under oxidative stress conditions
No full textAre the γ-glutamyl-amino acids signals for the amino acid uptake by lactating mammary gland?
No full textBlood flow and net amino acid uptake by the lactating mammary gland: effect of starvation
No full textBlood sulfur-amino acid concentration reflects an impairment of liver transsulfuration pathway in patients with acute abdominal inflammatory processes
No full textLiver intracellular L-cysteine concentration is maintained after inhibition of the trans-sulfuration pathway by propargylglycine in rats
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