1 research outputs found
Adverse cutaneous drug reactions: Clinical pattern and causative agents in a tertiary care center in South India
Background: Adverse cutaneous drug reactions (ACDRs) are caused by a
wide variety of agents. Aims: Our objective was to ascertain the
clinical spectrum of ACDRs and the causative drugs in this part of
India and to find any risk factors. Methods: Ninety patients with
adverse cutaneous drug reactions were recruited for this study during
2001-2003. Hematological and biochemical investigations were done in
all of them. The VDRL and HIV (ELISA) tests were performed where the
underlying risk factors were present. Patch testing, intradermal
testing and oral provocation tests were done wherever feasible.
Results: The mean age of the patients with cutaneous drug eruptions was
37.06 years. Most of them (52.2%) were in the age group of 20-39 years.
The male to female ratio was 0.87: 1. The most common eruptions
observed were fixed drug eruption (31.1%) and maculopapular rash
(12.2%), and the most common causes were co-trimoxazole (22.2%) and
dapsone (17.7%). Conclusion: The pattern of ACDRs and the drugs causing
them is remarkably different in our population. Knowledge of these drug
eruptions, the causative drugs and the prognostic indicators is
essential for the clinician