Information-aware access network selection

Mobile devices are increasingly presented with multiple connectivity options, including WiFi hotspots, micro-/macro-cells or even other devices in device-to-device (D2D) communications. By and large, connectivity management for mobile devices has primarily focused on contention, congestion and wireless medium conditions. In this paper, we assess the role of information-centrism in mobile device connectivity management. Motivated by the increasing availability of content and services in in-network caches and micro-data centres, we design an access network selection scheme that takes into account information availability within each connectivity option. Our simulations show that information-awareness results in a significant increase of cache hit ratios by up to 115% in certain scenarios

On the feasibility of a user-operated mobile content distribution network

The vast majority of mobile data transfers today follow the traditional client-server model. Although in the fixed network P2P approaches have been exploited and shown to be very efficient, in the mobile domain there has been limited attempt to leverage on P2P (D2D) for large-scale content distribution (i.e., not DTN-like, point-to-point message transfers). In this paper, we explore the potential of a user-operated, smartphone-centric content distribution model for smartphone applications. In particular, we assume source nodes that are updated directly from the content provider (e.g., BBC, CNN), whenever updates are available; destination nodes are then directly updated by source nodes in a D2D manner. We leverage on sophisticated information-aware and application-centric connectivity techniques to distribute content between mobile devices in densely-populated urban environments. Our target is to investigate the feasibility of an opportunistic content distribution network in an attempt to achieve widespread distribution of heavy content (e.g., video files) to the majority of the destination nodes. We propose ubiCDN as a ubiquitous, user-operated and distributed CDN for mobile applications

ESPRAS Survey on Continuing Education in Plastic, Reconstructive and Aesthetic Surgery in Europe

Background Specialty training in plastic, reconstructive and aesthetic surgery is a prerequisite for safe and effective provision of care. The aim of this study was to assess and portray similarities and differences in the continuing education and specialization in plastic surgery in Europe. Material and Methods A detailed questionnaire was designed and distributed utilizing an online survey administration software. Questions addressed core items regarding continuing education and specialization in plastic surgery in Europe. Participants were addressed directly via the European Leadership Forum (ELF) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS). All participants had detailed knowledge of the organization and management of plastic surgical training in their respective country. Results The survey was completed by 29 participants from 23 European countries. During specialization, plastic surgeons in Europe are trained in advanced tissue transfer and repair and aesthetic principles in all parts of the human body and within several subspecialties. Moreover, rotations in intensive as well as emergency care are compulsory in most European countries. Board certification is only provided for surgeons who have had multiple years of training regulated by a national board, who provide evidence of individually performed operative procedures in several anatomical regions and subspecialties, and who pass a final oral and/or written examination. Conclusion Board certified plastic surgeons meet the highest degree of qualification, are trained in all parts of the body and in the management of complications. The standard of continuing education and qualification of European plastic surgeons is high, providing an excellent level of plastic surgical care throughout Europe

Rethinking stasis and utopianism: empty placards and imaginative boredom in the Greek crisis-scape

This chapter traces specific modalities for performing stasis and rethinking utopianism against the backdrop of the recent financial crisis in Greece and, generally, of conditions shaped within the totalizing order Mark Fisher has called “capitalist realism.” Boletsi probes the ways two works deal with the (im)possibility of resistance from within the neoliberal “now”: the short story “Placard and Broomstick” (Ikonomou) and an Athenian wall writing that translates as “I am bored imaginatively.” The empty placard that takes center stage in Ikonomou’s story and the imaginative boredom registered on the walls of Athens test different modalities of stasis against alienation, dispossession, and the contracting of the future. Boletsi argues that both works disengage from conceptions of subjectivity that rest on the binary of either a passive or an active subject—either an acquiescent victim or a revolutionary hero who challenges power from its outside. The story stages the desire for alternative languages by registering a crisis of representation and the inadequacy of existing narratives. The wall writing taps into the modality of the “middle voice” to reconfigure one of the symptoms of capitalist realism—the boredom of unemployment, consumerism, or an indebted life—into a potential resource for different modes of being that carry glimpses of utopianism. Both works, albeit differently, challenge neoliberal imperatives of acquiescence, normalization, or “moving forward.” Although they stage the limited possibilities for resistance within a totalizing system, they also enable alternative configurations of subjectivity, agency, and futurity.Modern and Contemporary Studie

Systemic therapy of Cushing’s syndrome

Cushing’s disease (CD) in a stricter sense derives from pathologic adrenocorticotropic hormone (ACTH) secretion usually triggered by micro- or macroadenoma of the pituitary gland. It is, thus, a form of secondary hypercortisolism. In contrast, Cushing’s syndrome (CS) describes the complexity of clinical consequences triggered by excessive cortisol blood levels over extended periods of time irrespective of their origin. CS is a rare disease according to the European orphan regulation affecting not more than 5/10,000 persons in Europe. CD most commonly affects adults aged 20–50 years with a marked female preponderance (1:5 ratio of male vs. female). Patient presentation and clinical symptoms substantially vary depending on duration and plasma levels of cortisol. In 80% of cases CS is ACTH-dependent and in 20% of cases it is ACTH-independent, respectively. Endogenous CS usually is a result of a pituitary tumor. Clinical manifestation of CS, apart from corticotropin-releasing hormone (CRH-), ACTH-, and cortisol-producing (malign and benign) tumors may also be by exogenous glucocorticoid intake. Diagnosis of hypercortisolism (irrespective of its origin) comprises the following: Complete blood count including serum electrolytes, blood sugar etc., urinary free cortisol (UFC) from 24 h-urine sampling and circadian profile of plasma cortisol, plasma ACTH, dehydroepiandrosterone, testosterone itself, and urine steroid profile, Low-Dose-Dexamethasone-Test, High-Dose-Dexamethasone-Test, after endocrine diagnostic tests: magnetic resonance imaging (MRI), ultra-sound, computer tomography (CT) and other localization diagnostics. First-line therapy is trans-sphenoidal surgery (TSS) of the pituitary adenoma (in case of ACTH-producing tumors). In patients not amenable for surgery radiotherapy remains an option. Pharmacological therapy applies when these two options are not amenable or refused. In cases when pharmacological therapy becomes necessary, Pasireotide should be used in first-line in CD. CS patients are at an overall 4-fold higher mortality rate than age- and gender-matched subjects in the general population. The following article describes the most prominent substances used for clinical management of CS and gives a systematic overview of safety profiles, pharmacokinetic (PK)-parameters, and regulatory framework