Properties of HERA Events from DIS on Pions in the Proton

Recently the concept of the pion cloud in the nucleon turned out to be successful in understanding the Gottfried sum rule violation observed by the New Muon Collaboration and the Drell--Yan asymmetry measured in NA51 at CERN. We propose a further possibility to test this concept at HERA through the analysis of the structure of deep inelastic scattering (DIS) events induced by pion--exchange. Momentum and energy distributions of outgoing nucleons as well as rapidity and multiplicity distributions are investigated using Monte Carlo simulations. Most observables cannot distinguish this process from ordinary DIS, but in the energy distribution of final neutrons we find a significantly different prediction from the pion cloud model. Forward neutron calorimeters will be essential to test the concept of pions in the nucleon.Comment: LaTeX file and gziped tar file with eps figures, 14 page

Recent results on soft probes of the Quark-Gluon Plasma from the ATLAS experiment at the LHC

AbstractMeasurements of low-pT particle production have provided valuable insight on the production and evolution of the quark-gluon plasma in Pb+Pb collisions at the LHC. In particular, measurements of collective flows and their anisotropies directly probe the strongly-coupled dynamics of the quark-gluon plasma and test hydrodynamic model descriptions of its evolution. We present recent results from a variety of single and multi-particle measurements in lead-lead and proton-lead collisions with the ATLAS detector that probe the collective dynamics of the quark-gluon plasma and possibly provide evidence for collectivity even in small systems

Dexrazoxane decreases the cardiotoxic effects of doxorubicin in osteosarcoma patients without increasing mortality from secondary malignant neoplasms

A clinical decision report appraising: Schwartz CL, Wexler LH, Krailo MD, et al. Intensified chemotherapy with dexrazoxane cardioprotection in newly diagnosed nonmetastatic osteosarcoma: A report from the Children’s Oncology Group. Pediatr Blood Cancer. 2016;63(1):54-615. https://doi.org/10.1002/pbc.25753 for a patient with osteosarcoma and concerns about the risk of secondary malignant neoplasms that attend use of dexarazoxane

ELIZABETH BISHOP: POET OR CHARACTER? THE RECEPTION OF BISHOP'S WORK IN THE UNITED STATES AND IN BRAZIL

Este trabalho se propõe a analisar a fortuna crítica da obra da poeta Elizabeth Bishop nos Estados Unidos e no Brasil, detendo-se nas transformações que marcaram os processos de leitura de sua obra poética nas últimas décadas, do formalismo textual da Nova Crítica ao historicismo que reinstala o contexto da obra, culminando no "biografismo" que transforma a poeta em personagem

High energy bremsstrahlung at the FCC-ee, FCC-eh and LHeC

Bremsstrahlung spectra will be strongly distorted due to small lateral beam sizes at future colliders. That in turn will have large consequences for the electron and positron beam lifetimes as well as for the luminosity measurements in the case of electron-hadron colliders. We discuss in detail such consequences for the Future Circular Collider and Large Hadron electron Collider cases

Design of a continuous precipitation operation for protein capture

Increasing product titers challenge chromatographic separations and play to the strengths of bulk separation techniques such as precipitation and liquid-liquid extraction. Further, bulk separation techniques lend themselves readily to true continuous operation without complex equipment. Here we describe the design of a continuous precipitation process for the capture of monoclonal antibodies from concentrated (~100 g/L) cell culture media. A continuous tubular reactor design with static mixing elements was implemented to ensure that each fluid element experienced the same mixing conditions between target and precipitant streams and the same overall fluid shear rate history. The continuous tubular format also permitted the independent control of the perikinetic and orthokinetic phases of precipitation through the spatially sequential addition of multiple precipitants (ZnCl2 and PEG3350). The space-time of the perikinetic precipitation portion of the reactor was determined by the characteristic time-scale of perikinetic aggregation; the space-time of the orthokinetic aggregation portion of the reactor was similarly determined. The Camp number of the process was sufficient to produce a stable particle size distribution. Runs conducted with an industrial partner resulted in yields exceeded 80%,~2.5x reduction in HCPs, and ~16x reduction in LMW impurities. An added benefit of the precipitation operation was that the dewatered precipitate phase had 90+ days of storage stability at between 2 to 8 °C, permitting the insertion of a hold step if needed. The process scaled readily from 50 L to 1000 L by matching power input per unit volume, producing reproducible particle size distributions, yields and purities: for scale up it is possible to both number up and up-size the hardware; it is also possible to scale the continuous process down for small-scale process development work

A fully continuous downstream process concept without column chromatography

We propose a continuous coupled precipitation-filtration process concept as the centerpiece of a fully continuous, column chromatography-free downstream process for recombinant protein manufacture. We expect the process to be generalizable to a wide range of proteins and to offer performance, raw material usage, simplicity and cost advantages relative to packed bed chromatography-based processes, thereby forming the basis for a new, integrated continuous downstream manufacturing paradigm for the production of recombinant proteins. The process is aimed at high-titer products and is based on target pre-concentration and precipitation in the capture step followed by precipitate washing and re-dissolution. A novel format consisting of tubular contactor - hollow fiber filter pairs is used, with controlled precipitation in the contactor and removal of soluble components in the hollow fiber membrane. Subsequent orthogonal, flow-through polishing operations are conducted with either membrane chromatography units or with chromatographic media slurries in contactor-filter pairs. This format allows for fully continuous and counter-current operation of several process steps, increasing efficiency and productivity. We have demonstrated the central precipitation and precipitate filtration capture operation with several proteins and are developing the thermodynamic, kinetic and operational models necessary for de novo process design and selection of optimal operating conditions. We have demonstrated: the effectiveness of synergistic pairings of volume excluding and cross-linking precipitants with mAbs and other globular proteins, the existence of yield-purity synergies rather than trade-offs, the ability to produce different precipitate particle morphologies (size distributions and fractal dimensions), the ability to scale precipitations up by x20 and down by x50 while maintaining particle morphology, the ability to dewater precipitates in hollow fiber membrane modules and the dependence of filtration critical flux performance in hollow fiber membrane modules on precipitate morpholog