Proposed therapeutic range of treosulfan in reduced toxicity pediatric allogeneic hematopoietic stem cell transplant conditioning: results from a prospective trial

Treosulfan is given off‐label in pediatric allogeneic hematopoietic stem cell transplant. This study investigated treosulfan's pharmacokinetics (PKs), efficacy, and safety in a prospective trial. Pediatric patients (n = 87) receiving treosulfan‐fludarabine conditioning were followed for at least 1 year posttransplant. PKs were described with a two‐compartment model. During follow‐up, 11 of 87 patients died and 12 of 87 patients had low engraftment (≤ 20% myeloid chimerism). For each increase in treosulfan area under the curve from zero to infinity (AUC(0‐∞)) of 1,000 mg hour/L the hazard ratio (95% confidence interval) for mortality increase was 1.46 (1.23–1.74), and the hazard ratio for low engraftment was 0.61 (0.36–1.04). A cumulative AUC(0‐∞) of 4,800 mg hour/L maximized the probability of success (> 20% engraftment and no mortality) at 82%. Probability of success with AUC(0‐∞) between 80% and 125% of this target were 78% and 79%. Measuring PK at the first dose and individualizing the third dose may be required in nonmalignant disease

Authenticity and Racism: Young boys in three inner city primary schools in Dublin

This paper examines the role of authenticity as a moral orientation and social evaluation in practices of racism. It will argue that discursive conceptions of authenticity disguise and legitimise racism within micro encounters. Using evidence from a qualitative study of minority children in Ireland, this paper explores how perceptions of ‘authenticity’ are bound within racist and gendered conceptions of whom can be said to legitimately embody nationally and locally authorised dispositions and identity markers. The specific context of how this played out through the locality of north Dublin and constructed notions of Irishness is examined. The wider implications of a discourse of authenticity are discussed in relation to assumptions of similarity, adaptation and integration. This paper contributes two unique insights, firstly, that the passive body (one’s appearance) has a central role in perceptions of authenticity and, secondly, that similarity in one’s active body (dispositions and tastes) does not necessarily act as a bridge to bring racialised groups together or facilitate integration