Ionic Liquids: A New Strategy in Pharmaceutical Synthesis

The industrial synthesis of pharmaceutical compounds often involves the use of organic solvents. Unfortunately, these reaction media are responsible for organic contaminations in the final product. In recent years, ionic liquids (ILs) have become the “green alternatives” of volatile organic solvents. Thus, the application of ILs instead of conventional reagents offer a new opportunity to solve problems of environmentally harmful solvents. This mini-review discusses a new application of ILs in laboratory-scale pharmaceutical synthesis

Affinity Chromatography Method for Determination of Binding of Drugs to Melanin and Evaluation of Side Effect Potential of Antipsychotic Agents

The extrapyramidal side effect parameters of typical and atypical antypsychotics were correlated with affinity chromatographic data determined on the melanin-based column. The chromatographic study was performed according to the hypothesis that extrapyramidal symptoms (EPS) as side effects of the use of antipsychotic drugs at clinically effective doses are correlated to the affinity of these drugs to neuromelanin. For that aim the polymerization product of L-DOPA (melanin) was immobilized onto aminopropyl silica and the binding efficiency of melanin towards antipsychotics has been determined. The results indicate that melanin based-column can be used to evaluate the risk of EPS of drug candidates to antipsychotic drug therapy

Ionic liquids – new possibilities in synthesis of pharmaceutical compounds

The industrial synthesis of active pharmaceutical ingredients (API) often involves a multistage process. The fi nal pharmaceutical product is at high risk of being contaminated by various organic ingredients. In recent years, ionic liquids (ILs) have become alternatives for the volatile organic solvents. Their application instead of conventional solvents as a reaction medium enables to solve problem with low-purity synthesis of pharmaceutical compounds. In this review a new application of ILs in pharmaceutical synthesis in laboratory-scale was described.Synteza farmakologicznie aktywnych związków na skalę przemysłową jest często procesem wieloetapowym, wymagającym użycia organicznych rozpuszczalników, co wiąże się z ryzykiem zanieczyszczenia końcowego produktu (substancji leczniczej) związkami organicznymi. W ostatnich latach ciecze jonowe (ionic liquids – ILs) stały się alternatywą dla organicznych lotnych rozpuszczalników. Zastosowanie ILs jako środowiska reakcji zamiast konwencjonalnych rozpuszczalników umożliwia rozwiązanie problemu zanieczyszczenia leków na etapie syntezy. W pracy opisano nowe aplikacje ILs w syntezie substancji leczniczych na skalę laboratoryjną