The Role of Genetic Polymorphism in the Formation of Arterial Hypertension, Type 2 Diabetes and their Comorbidity

Background: Hereditary component plays a significant role in the formation of insulin resistance (IR) - one of the pathogenetic links of arterial hypertension (AH) and type 2 diabetes mellitus (DM2). However, the genetic predisposition to IR can not be realized and does not manifest itself clinically in the absence of appropriate factors of the environment (excessive nutrition, low physical activity, etc.). Objective: The review summarizes the results of studies which describe the contribution of genetic polymorphism to the formation and progression of AH, DM2 and their comorbidity in various populations. Results: In many studies, it has been established that genetic polymorphism of candidate genes is influenced by the formation, course and complication of AH and DM2. According to research data, the modulating effect of polymorphism of some genetic markers of AH and DM2 on metabolism and hemodynamics has been established. The results of numerous studies have shown a higher frequency of occurrence of AH and DM2, as well as their more severe course with adverse genetic polymorphisms. At the same time, the role of genetic polymorphism in the formation of AH and DM2 differs in different populations. Conclusion: Contradictory data on the influence of gene polymorphisms on the formation of AH and DM2 in different populations, as well as a small number of studies on the combined effects of several polymorphisms on the formation of comorbidity, determine the continuation of research in this direction

Metabolic disorders and the state of the renin-angiotensin-aldosterone system in obese patients with resistant hypertension

The study included 200 patients with uncontrolled AH and obesity. Obese patients with true resistance differed from pseudo–resistant patients with significantly lower BMI, higher aldosterone levels, and less pronounced adipokines imbalance

Hemodynamic and metabolic disorders in obese patients with resistant hypertension

Patients with resistant hypertension differed from hypertensive obese patients without resistance with higher BMI and BP, higher levels of triglycerides, insulin, HbA1c, more pronounced IR, cardiovascular remodeling, imbalance of oxidative stress - antioxidant protection system, higher proinflammatory and RAAS activity. Patients with true resistance differed from pseudo-resistant patients with significantly lower BMI, higher aldosterone levels, more pronounced imbalance of the system of oxidative stress - antioxidant protection and less pronounced adipokines imbalance

Сучасна практика внутрішньої медицини з невідкладними станами. Ведення хворих з комою

Coma (or unconsciousness) is a state in which a patient is totally unaware of both self and external surroundings, and unable to respond meaningfully to external stimuli. Coma results from gross impairment of both cerebral hemispheres, and/or the ascending reticular activating system. There are many causes of coma (including Newcastle Brown Ale), and these may be classified as either focal or diffuse brain dysfunction