Problems of improving clients quality service in the tour operator activities

The problem of quality management services relevance for the tour operator activities. Due to the increasing needs of customers, increases need to improve service technology and raising service quality management.Проблема управления качеством услуг актуальна для туристских фирм в связи с возрастающими потребностями клиентов, увеличивается необходимость в совершенствовании технологий обслуживания и повышения уровня управления качеством услуг. В статье предложен вариант стандарта выездного обслуживания клиентов туристских фирм

Environmental Improvement Of Opencast Mining

Existing classifications of waste dumps in the quarries are given and their phenomenological nature is clarified. The need to identify the essence of the term "dump" is shown as well as the idea of "dump" as an artificial formation with everted and mixed rocks distanced from the quarry. Essential classification of man-made rock formations in quarries is developed. Characteristic of variations of man-made waste formations in quarries is developed. To reduce harmful effects of open-pit mining, dumps should be substituted with strat-lays - man-made structures relevant to natural stratification of litho-substances. Construction of strat-lays would improve ecological and technological culture of open cast mining

RoboCup 2D Soccer Simulation League: Evaluation Challenges

We summarise the results of RoboCup 2D Soccer Simulation League in 2016 (Leipzig), including the main competition and the evaluation round. The evaluation round held in Leipzig confirmed the strength of RoboCup-2015 champion (WrightEagle, i.e. WE2015) in the League, with only eventual finalists of 2016 competition capable of defeating WE2015. An extended, post-Leipzig, round-robin tournament which included the top 8 teams of 2016, as well as WE2015, with over 1000 games played for each pair, placed WE2015 third behind the champion team (Gliders2016) and the runner-up (HELIOS2016). This establishes WE2015 as a stable benchmark for the 2D Simulation League. We then contrast two ranking methods and suggest two options for future evaluation challenges. The first one, "The Champions Simulation League", is proposed to include 6 previous champions, directly competing against each other in a round-robin tournament, with the view to systematically trace the advancements in the League. The second proposal, "The Global Challenge", is aimed to increase the realism of the environmental conditions during the simulated games, by simulating specific features of different participating countries.Comment: 12 pages, RoboCup-2017, Nagoya, Japan, July 201

Adaptive potential assessment of future teachers at the first stage of their professional training

The health-saving component of the educational environment requires improvement in the organization of physical culture and health, medical and preventive, psychological and pedagogical work to overcome maladjustment and develop the models of personal safe behavior from the first steps in the teaching professio

An analysis of quadrupole splitting of the Mössbauer spectra of ferritin and iron-dextran complexes in relation to the iron core microstructural variations

Mössbauer spectra of human liver ferritin and some pharmaceutically important iron-dextran complexes as ferritin models were measured at 87 K (frozen solutions) and at both 87 and 295 K (lyophilized forms). The Mössbauer spectra consisted of paramagnetic doublets only. However, the spectral line shapes were not Lorentzian and these Mössbauer spectra were better fitted using a superposition of two or more quadrupole doublets or using a distribution of quadrupole splittings. The differences of the maximal quantity of quadrupole doublets for better fitting of various Mössbauer spectra of ferritin and iron-dextran complexes were compared with the fitting using the distribution of quadrupole splitting for additional analysis. It is possible that variations of the quantity of quadrupole doublets for better fitting of Mössbauer spectra of ferritin and iron-dextran complexes may be related to heterogeneous iron cores in the samples. This heterogeneity is supposed to be different for various samples and changed for lyophilized samples and for frozen solutions as well as for various temperatures

Association of Blood MicroRNA Expression and Polymorphisms with Cognitive and Biomarker Changes in Older Adults

BackgroundIdentifying individuals before the onset of overt symptoms is key in the prevention of Alzheimer's disease (AD).ObjkectivesInvestigate the use of miRNA as early blood-biomarker of cognitive decline in older adults.DesignCross-sectional.SettingTwo observational cohorts (CHARIOT-PRO, Alzheimer's Disease Neuroimaging Initiative (ADNI)).Participants830 individuals without overt clinical symptoms from CHARIOT-PRO and 812 individuals from ADNI.MeasurementsqPCR analysis of a prioritised set of 38 miRNAs in the blood of individuals from CHARIOT-PRO, followed by a brain-specific functional enrichment analysis for the significant miRNAs. In ADNI, genetic association analysis for polymorphisms within the significant miRNAs' genes and CSF levels of phosphorylated-tau, total-tau, amyloid-& beta;42, soluble-TREM2 and BACE1 activity using whole genome sequencing data. Post-hoc analysis using multi-omics datasets.ResultsSix miRNAs (hsa-miR-128-3p, hsa-miR-144-5p, hsa-miR-146a-5p, hsa-miR-26a-5p, hsa-miR-29c-3p and hsa-miR-363-3p) were downregulated in the blood of individuals with low cognitive performance on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The pathway enrichment analysis indicated involvement of apoptosis and inflammation, relevant in early AD stages. Polymorphisms within genes encoding for hsa-miR-29c-3p and hsa-miR-146a-5p were associated with CSF levels of amyloid-& beta;42, soluble-TREM2 and BACE1 activity, and 21 variants were eQTL for hippocampal MIR29C expression.Conclusionssix miRNAs may serve as potential blood biomarker of subclinical cognitive deficits in AD. Polymorphisms within these miRNAs suggest a possible interplay between the amyloid cascade and microglial activation at preclinical stages of AD