CLINICAL AND IMMUNOLOGICAL SUBSTANTIATION OF β-CAROTENE USE IN PRE-SCHOOL CHILDREN

The article presents the results of an observation of pre-school children, treated with -carotene (Vetoron) in complex of sanitary measures. Special immunological examination showed that the medication has not specific stimulating influence on immune system in children 3–6 years old. The advisability of its administration as a non-specific medication for the prophylaxis of respiratory diseases is confirmed by the increase of ?-interferon production, probably due to non-specific activation or modulation of NK-cells.Key words: children, β-carotene, interferon.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(1):32-36

Complex treatment of recurrent cystitis with neurogenic bladder dysfunction in girls

[No abstract available

Complex treatment of recurrent cystitis with neurogenic bladder dysfunction in girls

[No abstract available

A prospective, open-label, non-comparative study of palivizumab prophylaxis in children at high risk of serious respiratory syncytial virus disease in the Russian Federation

Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections (LRTIs) in children globally. Predisposing conditions for the development of serious RSV disease include preterm infants and those with cardiopulmonary illness, including congenital heart disease (CHD) and bronchopulmonary dysplasia (BPD). No vaccine is currently approved for the prevention of RSV infection. It is recommended that children at high risk be prophylactically administered palivizumab, a monoclonal antibody that has been shown in a number of clinical studies to reduce hospitalization rates due to serious RSV infection. The objective of the current study was to determine the safety and effectiveness of palivizumab in preventing serious RSV disease in high-risk children in the Russian Federation. Children at high risk of serious RSV disease (ie, born at ≤35 wk gestational age and ≤6 mo of age, and/or aged ≤24 mo with BPD or hemodynamically significant CHD) were enrolled. Subjects were to receive 3 to 5 monthly injections of palivizumab 15 mg/kg (depending on the month of the initial injection) over the RSV season. The primary endpoint was RSV-related hospitalizations. Adverse events (AEs) were reported through 100 days following the final injection. Results: One hundred subjects received ≥1 injection of palivizumab; 94 completed their dosing schedule. There were no RSV hospitalizations or deaths. Six of 7 subjects hospitalized for respiratory/cardiac conditions had an RSV test, which was negative in all cases. Three non-serious AEs (acute intermittent rhinitis and rhinitis, 1 subject; atopic dermatitis, 1 subject) were considered possibly related to palivizumab. All other AEs were mild or moderate and considered not related/probably not related to palivizumab. Conclusion: Palivizumab was generally well tolerated and effectively prevented serious RSV infection in a mixed population of high-risk children in the Russian Federation. Trial registration. ClinicalTrials.gov: NCT01006629. © 2012 Turti et al.; licensee BioMed Central Ltd