CONSTRUCT GUARD

Construction sites still have safety issues, which has led to the creation of cutting-edge. The Proposed Solution is Smart wearable bands and helmets equipped with a variety of sensors for tracking employee health and safety. The technology, which is supported by a connected wearable belt, continuously tracks worker location and health parameters. An advanced accelerometer detects workers' standing positions, triggering instant notifications to contractors in the event of dizziness. A Spo2 sensor enhances total health surveillance by monitoring oxygen and pulse rates in addition to the foregoing. This proposed system transcends traditional safety protocols, presenting a dynamic and proactive approach to worker well-being.  By leveraging advanced sensor technologies and location-based intelligence, our smart wearables provide real-time health insights and prompt alerts during health compromises or accidents

\u3cem\u3eChlamydomonas\u3c/em\u3e mutants display reversible deficiencies in flagellar beating and axonemal assembly

Axonemal complexes in flagella are largely prepackaged in the cell body. As such, one mutation often results in the absence of the co-assembled components and permanent motility deficiencies. For example, a Chlamydomonas mutant defective in RSP4 in the radial spoke (RS), which is critical for bend propagation, has paralyzed flagella that also lack the paralogue RSP6 and three additional RS proteins. Intriguingly, recent studies showed that several mutant strains contain a mixed population of swimmers and paralyzed cells despite their identical genetic background. Here we report a cause underlying these variations. Two new mutants lacking RSP6 swim processively and other components appear normally assembled in early log phase indicating that, unlike RSP4, this paralogue is dispensable. However, swimmers cannot maintain the typical helical trajectory and reactivated cell models tend to spin. Interestingly the motile fraction and the spokehead content dwindle during stationary phase. These results suggest that (1) intact RS is critical for maintaining the rhythm of oscillatory beating and thus the helical trajectory; (2) assembly of the axonemal complex with subtle defects is less efficient and the inefficiency is accentuated in compromised conditions, leading to reversible dyskinesia. Consistently, several organisms only possess one RSP4/6 gene. Gene duplication in Chlamydomonas enhances RS assembly to maintain optimal motility in various environments

Maternal and perinatal outcome in preterm premature rupture of membranes

Background: Preterm premature rupture of membranes (PPROM) and preterm birth results in one third of perinatal mortality and maternal morbidity such as chorioamnionitis and abruption placenta and preterm caesarean section, Preterm premature rupture of membranes occurs in 3% of pregnancies. PPROM is associated with intrauterine infection. Early detection of intrauterine infection may help in prevent neonatal sepsis. Objective of present study was to analyse the maternal and perinatal outcome of PPROM patients between 28 to 36 weeks +6 days and predict intrauterine infection by access the level of C reactive protein to prevent chorioamnionitis and neonatal infection. Methods: A descriptive study was conducted on 126 antenatal patients between 24 to 36 weeks+6 days with PPROM admitted to Department of Obstetrics and Gynaecology, Cheluvamba Hospital Mysore medical college, Mysore, Karnataka, India from February 2022 to July 2022. After establishing the diagnosis of PPROM patients were monitored and maternal and perinatal outcomes were studied. Results: 24% patients had late PPROM. 63% of early PPROM latency period >24 hours and were managed conservatively till 34 weeks. 18% had chorioamnionitis in that 12% CRP positive status and immediate termination of pregnancy. 73% of newborns in this group needed admission due to complications of prematurity like RDS (54.54%). Perinatal mortality (2.12%) was due to sepsis. 80% of late PPROM had latency period 24 hours and sepsis was 36% in >24 hours and 10% in <24 hours. Conclusions: The most common cause of perinatal mortality in early PPROM is prematurity and its complications. Hence conservative management to prolong pregnancy is recommended under strict monitoring for evidence of chorioamnionitis. C-reactive protein helps to pick up chorioamnionitis early. At the earliest evidence of chorioamnionitis termination irrespective of gestational age is warranted. In late PPROM, perinatal outcome is good. So, termination is advised as conservative management shall add to the fetal and maternal morbidity due to sepsis